Identification of genetic variation in the human serotonin 1D beta receptor gene.

abstract：:Cognitive impairment, acute or long-term, is a common complication in patients with severe bacterial infection. However, the underlying mechanisms are not fully verified and effective medicine is not available in clinics. Interferon gamma (IFNγ) is a pivotal cytokine against infection and is believed to be a tune in h...

journal_title：Biochemical and biophysical research communications

authors： Lu Y,Yang Y,Peng Z,Xie L,Zhong X,Liang F,Yuan C,Lu B

更新日期：2020-12-17 00:00:00

abstract：:To relate specific effects on growth and transformation to activation of specific affinity states of the CCKA receptor stably expressed in CHO cells we compared responses to the CCK analogues JMV-180 and CCK8. CCK8 led to an inhibition of both cell proliferation and transformation. Effects on proliferation were indica...

journal_title：Biochemical and biophysical research communications

authors： Detjen K,Tseng MJ,Logsdon CD

更新日期：1995-08-04 00:00:00

abstract：:Sheep thyroid cells cultured in serum-free medium were used to study the biologic activity, binding, and production of the insulin-like growth factors (IGFs). IGF-I, IGF-II, and insulin stimulated thyroid cell division. Abundant, specific IGF receptors on sheep thyroid cell membranes were identified by binding displac...

journal_title：Biochemical and biophysical research communications

authors： Bachrach LK,Eggo MC,Hintz RL,Burrow GN

更新日期：1988-08-15 00:00:00

abstract：:Cyclooxygenase 2 (COX)-2 is induced by bacterial and viral infections and has complex, poorly understood roles in anti-pathogen immunity. Here, we use a knock-in luciferase reporter model to image Cox2 expression across a range of tissues in mice following treatment with the either the prototypical bacterial pathogen-...

journal_title：Biochemical and biophysical research communications

authors： Kirkby NS,Zaiss AK,Wright WR,Jiao J,Chan MV,Warner TD,Herschman HR,Mitchell JA

更新日期：2013-08-23 00:00:00

abstract：:Nuclear-Factor-kappaB (NF-kappaBeta can counteract transforming growth factor-beta1 (TGF-beta1)-induced apoptosis in malignant hepatocytes through up-regulation of its downstream genes, such as X-linked inhibitor of apoptosis protein (XIAP). Reports have demonstrated that TGF-beta1 can induce oxidative stress, and c-J...

journal_title：Biochemical and biophysical research communications

authors： Wang F,Kaur S,Cavin LG,Arsura M

更新日期：2008-12-26 00:00:00

abstract：:Norepinephrine (NE) modulates brain functions depending on both the internal and external environment. While the neuromodulatory actions of NE have been well characterized, the response and involvement of cortical astrocytes to physiological noradrenergic systems remain largely unknown, especially at the molecular lev...

journal_title：Biochemical and biophysical research communications

authors： Nuriya M,Morita A,Shinotsuka T,Yamada T,Yasui M

更新日期：2018-10-12 00:00:00

abstract：:Vibrio vulnificus, a halophilic estuarine bacterium causing a rapidly progressing fatal septicemia, is highly cytotoxic to eukaryotic cells. To identify new virulence factors associated with cytotoxicity, we constructed a mariner-based transposon (Tn Himar1) library of the highly virulent clinical isolate MO6-24/O hav...

journal_title：Biochemical and biophysical research communications

authors： Ran Kim Y,Haeng Rhee J

更新日期：2003-05-02 00:00:00

abstract：:To tailor tissue-type plasminogen activator (tPA) to possess an affinity for the integrins, several mutants were constructed by introducing the Arg-Gly-Asp (RGD) sequene into the tPA molecule. These mutants were expressed in COS-1 cells and partially purified by lysine-Sepharose chromatography. The RGD-dependent bindi...

journal_title：Biochemical and biophysical research communications

authors： Yamada T,Shimada Y,Kikuchi M

更新日期：1996-11-12 00:00:00

abstract：:A cDNA for the rat bone morphogenetic protein (BMP) type IA receptor (BMPR-IA) was isolated from a dental pulp cell cDNA library. The rat BMPR-IA cDNA encodes a protein of 532 amino acids with a single transmembrane domain and a putative serine/threonine kinase domain. The overall amino acid sequence identity between ...

journal_title：Biochemical and biophysical research communications

authors： Takeda K,Oida S,Ichijo H,Iimura T,Maruoka Y,Amagasa T,Sasaki S

更新日期：1994-10-14 00:00:00

abstract：:A rabbit cytochrome P-450IIE2 full-length cDNA was cloned into a yeast episomal plasmid (YEp13) between the copper-responsive yeast metallothionein gene promoter (CUP1) and the iso-1-cytochrome c gene terminator (CYC1), and the cytochrome P-450 was expressed in Saccharomyces cerevisiae. The microsomal fraction prepare...

journal_title：Biochemical and biophysical research communications

authors： Pernecky SJ,Porter TD,Coon MJ

更新日期：1990-11-15 00:00:00

abstract：:Tau plays important roles in the assembly and stabilization of the microtubule structure to facilitate axonal transport in mammalian brain. The intracellular tau aggregates to form paired helical filaments leading to neurodegenerative disorders, collectively called tauopathies. In our previous report, we established a...

journal_title：Biochemical and biophysical research communications

authors： Wu BK,Yuan RY,Chang YP,Lien HW,Chen TS,Chien HC,Tong TS,Tsai HP,Fang CL,Liao YF,Chang CC,Chen RP,Huang CJ

更新日期：2016-08-19 00:00:00

abstract：:The inhibitory effect of mercapto- and chlorodicarbanonaborates on mitochondrial, FAD-linked, L-glycerol-3-phosphate dehydrogenase activity was tested. The mercaptodicarbanonaborate was found to be a more potent inhibitor than the chloro derivative. The Ki of mercapto- and chlorodicarbanonaborates were 0.8 M and 480 M...

journal_title：Biochemical and biophysical research communications

authors： Drahota Z,Saf P,Rauchová H,Kalous M

更新日期：1995-05-25 00:00:00

abstract：:Rat neuromedin U was isolated from the small intestine using mainly immunoaffinity chromatography and radioimmunoassay for pig neuromedin U-8. The amino acid sequence of rat neuromedin U was determined by microsequence analysis to be Tyr-Lys-Val-Asn-Glu-Tyr-Gln-Gly-Pro-Val-Ala-Pro-Ser-Gly-Gly- Phe-Phe-Leu-Phe-Arg-Pro-...

journal_title：Biochemical and biophysical research communications

authors： Minamino N,Kangawa K,Honzawa M,Matsuo H

更新日期：1988-10-14 00:00:00

abstract：:Analysis of a 67 kDa lipid-dependent Ca(2+)-binding protein from avian matrix vesicles revealed amino acid sequences homologous to mammalian annexin VI. PCR methods were used to identify a clone from an avian cDNA library that contained a full length copy of the 67-kDa annexin cDNA. This was restriction mapped, subclo...

journal_title：Biochemical and biophysical research communications

authors： Cao X,Genge BR,Wu LN,Buzzi WR,Showman RM,Wuthier RE

更新日期：1993-12-15 00:00:00

abstract：:The ATP-binding cassette (ABC) transporter 2 (ABCG2) is expressed by stem cells in many organs and in stem cells of solid tumors. These cells are isolated based on the side population (SP) phenotype, a Hoechst 3342 dye efflux property believed to be conferred by ABCG2. Because of the limitations of this approach we ge...

journal_title：Biochemical and biophysical research communications

authors： Orford M,Mean R,Lapathitis G,Genethliou N,Panayiotou E,Panayi H,Malas S

更新日期：2009-06-26 00:00:00

abstract：:The effect of glucocorticoid hormones on the protein responsible for both nucleotide pyrophosphatase (EC 3.6.1.9) and alkaline phosphodiesterase I (EC 3.1.4.1) activities was examined in murine MOPC 315 plasmacytoma cells. Incubation of these cells with dexamethasone resulted in parallel increases in pyrophosphatase a...

journal_title：Biochemical and biophysical research communications

authors： Rebbe NF,Hickman S

更新日期：1991-03-15 00:00:00

abstract：:Integrins are a family of cell surface adhesion molecules which mediate cell adhesion and initiate signaling pathways that regulate cell spreading, migration, differentiation, and proliferation. TGF-beta is a multifunctional factor that induces a wide variety of cellular processes. In this study, we show that, TGF-bet...

journal_title：Biochemical and biophysical research communications

authors： Cai T,Lei QY,Wang LY,Zha XL

更新日期：2000-08-02 00:00:00

abstract：:Protocols were defined that enable patch-clamp studies of the approximately 107 pS voltage dependent channel and a class of activity we refer to as MCC (multiconductance channel) which is characterized by multiple levels and transitions as high as 1 to 1.5 nS. If free calcium was kept at 10(-7) M or lower during mitoc...

journal_title：Biochemical and biophysical research communications

authors： Kinnally KW,Zorov D,Antonenko Y,Perini S

更新日期：1991-05-15 00:00:00

abstract：:XAF1 (XIAP-associated factor 1) binds to XIAP and blocks its anti-apoptotic activity. It has been reported that XAF1 is mainly expressed in normal tissues but is missing or present at low levels in most cancer cell lines, which implies a tumor-suppressing function. In the present study we describe the identification o...

journal_title：Biochemical and biophysical research communications

authors： Yin W,Cheepala S,Clifford JL

更新日期：2006-01-27 00:00:00

abstract：:Tetrahymena p85 is localized to the presumptive division plane before division furrow formation; its molecular weight in SDS-polyacrylamide gel electrophoresis differs in wild-type and temperature-sensitive cell-division-arrest mutant cdaA1 cells. At the restrictive temperature, p85 localization and division furrow fo...

journal_title：Biochemical and biophysical research communications

authors： Gonda K,Nishibori K,Ohba H,Watanabe A,Numata O

更新日期：1999-10-14 00:00:00

abstract：:The effects of cyclosporin A (CSP) on tumor necrosis factor-alpha (TNF-alpha) RNA levels and protein production in human B cells and a B cell line were studied. The ability of CSP to block induction of RNA was compared to its inhibition of protein production in response to anti-IgM, phorbol ester (PMA) and platelet-ac...

journal_title：Biochemical and biophysical research communications

authors： Smith CS,Ortega G,Parker L,Shearer WT

更新日期：1994-10-14 00:00:00

abstract：:A clone of vincristine resistant murine erythroleukemia cells V3.17[44], characterized by high sensitivity to terminal erythroid differentiation induced by hexamethylene bisacetamide, secretes into the extracellular medium a protein factor which partially reduces the latent period before commitment and accelerates the...

journal_title：Biochemical and biophysical research communications

authors： Sparatore B,Patrone M,Salamino F,Passalacqua M,Melloni E,Pontremoli S

更新日期：1990-11-30 00:00:00

abstract：:We show that a histone deacetylase (HDAC) inhibitor apicidin increases the transcriptional activity of cyclin E gene, which results in accumulation of cyclin E mRNA and protein in a time- and dose-dependent manner. Interestingly, apicidin induction of cyclin E gene is found to be mediated by Sp1- rather than E2F-bindi...

journal_title：Biochemical and biophysical research communications

authors： Kim S,Kang JK,Kim YK,Seo DW,Ahn SH,Lee JC,Lee CH,You JS,Cho EJ,Lee HW,Han JW

更新日期：2006-04-21 00:00:00

abstract：:Gonadotropin releasing hormone (GnRH), preincubated with cultured rat pituitary cells, induced down regulation of GnRH receptors in a time- and dose-dependent manner. The specific binding was inhibited by 50% after 30 min and maximal inhibition (70%) was obtained after 75 min preincubation with 1 microM GnRH. Preincub...

journal_title：Biochemical and biophysical research communications

authors： Hazum E,Schvartz I

更新日期：1984-12-14 00:00:00

abstract：:Autologous hematopoietic stem cell transplantation (HSCT) has recently been performed as a novel strategy to treat patients with new-onset type 1 diabetes (T1D). However, the mechanism of autologous HSCT-induced remission of diabetes remains unknown. In order to help clarify the mechanism of remission-induction follow...

journal_title：Biochemical and biophysical research communications

authors： Wen Y,Ouyang J,Yang R,Chen J,Liu Y,Zhou X,Burt RK

更新日期：2008-09-19 00:00:00

abstract：:Bone marrow mesenchymal stem cells (BMMSCs) are pluripotent stem cells, and the osteogenic differentiation of BMMSCs has been drawing attention for a long time. Bone formation is regulated by numerous molecular and cellular signaling pathways, and the differentiation of BMMSCs is controlled by a well-defined genetic p...

journal_title：Biochemical and biophysical research communications

authors： Li X,Guo L,Liu Y,Su Y,Xie Y,Du J,Zhou J,Ding G,Wang H,Bai Y,Liu Y

更新日期：2017-11-18 00:00:00

abstract：:The expression of sucrase-isomaltase mRNA was investigated along the crypt-villus axis of rat small intestine using differentially isolated cells and in situ hybridization. A partial rat sucrase-isomaltase cDNA was cloned which coded for a protein that was predicted to be 88% homologous to those encoded by the rabbit ...

journal_title：Biochemical and biophysical research communications

authors： Traber PG

更新日期：1990-12-31 00:00:00

abstract：:The ΔpH-dependent/Tat pathway is unique for using only the proton motive force for driving proteins transport across the thylakoid membrane in chloroplasts. 9-aminoacridine fluorescence quenching is widely used to monitor the ΔpH developed across the thylakoid membrane in the light. However, this method suffers from l...

journal_title：Biochemical and biophysical research communications

authors： Yang H,Pu X,Wang L,Liu L,Theg SM

更新日期：2017-04-22 00:00:00

abstract：:p120-Catenin is known to play important roles in cell-cell adhesion stability by binding to cadherin and morphological changes of cells by regulating small RhoGTPase activities. Although the expression and binding states of p120-catenin are thought to dynamically change due to morphological adaptation of endothelial c...

journal_title：Biochemical and biophysical research communications

authors： Sakamoto N,Segawa K,Kanzaki M,Ohashi T,Sato M

更新日期：2010-07-30 00:00:00

abstract：:Carcinoembryonic antigen (CEA), a widely used tumor marker, is attached by a glycosylphosphatidylinositol (GPI) anchor motif to the cell membrane. Recent study suggested that membrane-bound CEA might be cleaved by glycosylphosphatidylinositol-phospholipase D (GPI-PLD). We studied the effect of GPI-PLD on the cleavage ...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto Y,Hirakawa E,Mori S,Hamada Y,Kawaguchi N,Matsuura N

更新日期：2005-07-22 00:00:00