A vincristine-resistant murine erythroleukemia cell line secretes a differentiation enhancing factor.

abstract：:Aggregation of the amyloid beta (Abeta) peptide yields both fibrillar precipitates and soluble oligomers, and is associated with Alzheimer's disease (AD). In vitro, Cu(2+) and Zn(2+) strongly bind Abeta and promote its precipitation. However, less is known about their interactions with the soluble oligomers, which are...

journal_title：Biochemical and biophysical research communications

authors： Garai K,Sengupta P,Sahoo B,Maiti S

更新日期：2006-06-23 00:00:00

abstract：:Messenger RNAs containing premature stop codons are generally targeted for degradation through the nonsense-mediated mRNA decay (NMD) pathway. The subcellular localization of the NMD process in higher eukaryotes remains controversial. While many mRNAs are subjected to NMD prior to their release from the nucleus, a few...

journal_title：Biochemical and biophysical research communications

authors： Dreumont N,Maresca A,Khandjian EW,Baklouti F,Tanguay RM

更新日期：2004-11-05 00:00:00

abstract：:(-)Bay K 8644 produced a concentration-dependent contraction of porcine coronary artery rings with the maximal contraction at 10(-6) M. Pretreatment of the rings with 10(-6) M nitrendipine inhibited (-)Bay K 8644-induced contraction, while pretreatment with 10(-8) M nitrendipine potentiated the contraction elicited by...

journal_title：Biochemical and biophysical research communications

authors： Miwa K,Schwartz A

更新日期：1987-10-14 00:00:00

abstract：:Certain PKC isoforms are stimulated by insulin and interact with IR as well as with IRS, but it is still not clear if specific PKC isoforms regulate IR signaling directly or through IRS-1. PKCalpha may regulate IRS activity in response to insulin. We investigated the possibility that PKCalpha may be important in insul...

journal_title：Biochemical and biophysical research communications

authors： Cipok M,Aga-Mizrachi S,Bak A,Feurstein T,Steinhart R,Brodie C,Sampson SR

更新日期：2006-06-30 00:00:00

abstract：:Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Kirsten rat sarcoma viral oncogene homolog (KRAS) is frequently mutated in CRC, and KRAS mutations promote cell motility, growth, and survival. We previously revealed that the expression of phospholipase C (PLC) δ1, one of the most...

journal_title：Biochemical and biophysical research communications

authors： Shimozawa M,Anzai S,Satow R,Fukami K

更新日期：2017-07-08 00:00:00

abstract：:Antigen-specific regulatory CD4(+) T cells have been described but there are few reports on regulatory CD8(+) T cells. We generated islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)-specific regulatory CD8(+) T cells from 8.3-NOD transgenic mice. CD8(+) T cells from 8.3-NOD splenocytes were...

journal_title：Biochemical and biophysical research communications

authors： Kishi M,Yasuda H,Abe Y,Sasaki H,Shimizu M,Arai T,Okumachi Y,Moriyama H,Hara K,Yokono K,Nagata M

更新日期：2010-03-26 00:00:00

abstract：:We demonstrate that the product of the yeast open reading frame YML005w is required for wybutosine (yW) formation in the phenylalanine-accepting tRNA of the yeast Saccharomyces cerevisiae. tRNA isolated from a deletion mutant of the YML005w gene accumulates 4-demethylwyosine (ImG-14), a precursor lacking three of the ...

journal_title：Biochemical and biophysical research communications

authors： Kalhor HR,Penjwini M,Clarke S

更新日期：2005-08-26 00:00:00

abstract：:Lipoprotein lipase (LPL) is present in cells involved in development of atherosclerosis (endothelial cells, smooth muscle cells, and macrophages). A direct involvement of LPL in atherogenesis has been suggested. Previously we used the surface plasmon resonance technique to study the interaction of lipoproteins with su...

journal_title：Biochemical and biophysical research communications

authors： Makoveichuk E,Lookene A,Olivecrona G

更新日期：1998-11-27 00:00:00

abstract：:Poly (ADP-ribose) polymerase 1 (PARP1) is an ADP- ribosylation enzyme and plays important roles in a variety of cellular processes, including DNA damage response and tumor development. However, the post-transcriptional regulation of PARP1 remains largely unknown. In this study, we identified that the mRNA of PARP1 is ...

journal_title：Biochemical and biophysical research communications

authors： Song D,Huang H,Wang J,Zhao Y,Hu X,He F,Yu L,Wu J

更新日期：2017-06-17 00:00:00

abstract：:The epididymal maturation of spermatozoa is regulated by changes in the luminal ion concentration and the processing of the sperm surface membrane by several glycosidases and proteases. In the present study, we identified five novel protease inhibitors that are highly expressed in the mouse epididymis. Four of the pro...

journal_title：Biochemical and biophysical research communications

authors： Jalkanen J,Kotimäki M,Huhtaniemi I,Poutanen M

更新日期：2006-10-13 00:00:00

abstract：:miRNAs are approximately 21nt non-coding RNAs and play important roles in plant development and response to stress. Symbiotic nitrogen fixation (SNF) is agronomically important for reducing the need of nitrogen fertilizers. The soybean root nodule is the place where SNF takes place. To identify miRNAs that are possibl...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Li P,Cao X,Wang X,Zhang A,Li X

更新日期：2009-01-23 00:00:00

abstract：:Hand-foot skin reaction (HFSR) is a common side effect of multiple tyrosine kinase inhibitors (mTKIs). HFSR can necessitate dose reductions or interruption of therapy owing to its negative effect on the quality of life. Therefore, effective use of mTKIs requires measures to prevent HFSR. We evaluated the effect of pro...

journal_title：Biochemical and biophysical research communications

authors： Shichiri H,Yamamoto K,Tokura M,Ishida T,Uda A,Bito T,Nishigori C,Nakagawa T,Hirano T,Yano I,Hirai M

更新日期：2017-04-01 00:00:00

abstract：:Previously, we have reported that two clustered cat genes from Acenitobacter lwoffi K24 had different arrangements, catB1C1A1 and catB2A2C2 (Kim, S.I., S.-H. Leem, J.-S. Choi, Y.H. Chung, S. Kim, Y.-M. Park, Y.K. Park, Y.N. Lee, and K.-S. Ha. 1997, J. Bacteriol. 179, 5226-5231). By further analysis of the organization...

journal_title：Biochemical and biophysical research communications

authors： Kim SI,Leem SH,Choi JS,Ha KS

更新日期：1998-02-04 00:00:00

abstract：:Fluid flowing through the bone porosity might be a primary stimulus for functional adaptation of bone. Osteoblasts, and osteocytes in particular, respond to fluid flow in vitro with enhanced nitric oxide (NO) and prostaglandin E(2) (PGE(2)) release; both of these signaling molecules mediate mechanically-induced bone f...

journal_title：Biochemical and biophysical research communications

authors： McGarry JG,Klein-Nulend J,Prendergast PJ

更新日期：2005-04-29 00:00:00

abstract：:The Sendai virus envelope contains two glycoproteins: the fusion (F) protein and the hemagglutinin-neuraminidase (HN). Inactivation of F causes the loss of fusogenic activity and an increase of the neuraminidase activity of HN. After inactivation of F, HN can be inhibited by fetuin or asialofetuin, as already observed...

journal_title：Biochemical and biophysical research communications

authors： Dallocchio F,Tomasi M,Bellini T

更新日期：1994-06-15 00:00:00

abstract：:Axonal transport of mitochondria is a microtubule-associated movement. Microtubule-mitochondria interactions were studied in vitro using organelles isolated from rat brain. Thanks to the ligand blotting method we were able to show two mitochondrial membrane proteins with apparent molecular masses of 30 kDa and 60 kDa ...

journal_title：Biochemical and biophysical research communications

authors： Rendon A,Filliol D,Jancsik V

更新日期：1987-12-16 00:00:00

abstract：:alpha-Difluoromethylornithine (DFMO) has been widely used for determining the amounts of ornithine decarboxylase (ODC) in cells. However, we have now found that DFMO does not react with ODC-antizyme complex, indicating that the amounts of radioactive DFMO bound to the protein may not reflect the amounts of ODC in crud...

journal_title：Biochemical and biophysical research communications

authors： Kitani T,Fujisawa H

更新日期：1986-06-30 00:00:00

abstract：:Differential methylation of CpG sites in the promoter region of the mouse Xist gene is correlated with Xist expression and X-chromosome inactivation in the female. Using oligonucleotides encompassing the differentially methylated sites as probes in band-shift assays, we have identified a nuclear protein which binds to...

journal_title：Biochemical and biophysical research communications

authors： Huntriss J,Lorenzi R,Purewal A,Monk M

更新日期：1997-06-27 00:00:00

abstract：:TGF beta is a multifunctional cytokine that regulates alveolar epithelial cells as well as immune cells and fibroblasts. TGF beta inhibits surfactant protein A, B and C expression in fetal human lung and can inhibit type II cell proliferation induced by FGF7 (KGF). However, little is known about direct effects of TGF ...

journal_title：Biochemical and biophysical research communications

authors： Correll KA,Edeen KE,Zemans RL,Redente EF,Mikels-Vigdal A,Mason RJ

更新日期：2018-05-23 00:00:00

abstract：:We found a novel protein-protein interaction between ubiquitin-specific protease 15 (USP15) and skeletal muscle LIM protein 1 (SLIM1): USP15 and SLIM1 directly bound under cell-free conditions and co-immunoprecipitated from the lysates of the cells, where they were co-expressed; and USP15 deubiquitinated SLIM1, result...

journal_title：Biochemical and biophysical research communications

authors： Isumi Y,Hirata T,Saitoh H,Miyakawa T,Murakami K,Kudoh G,Doi H,Ishibashi K,Nakajima H

更新日期：2011-02-11 00:00:00

abstract：:A novel human GPCR gene was cloned by PCR with degenerate primers designed from cannabinoid type 1 receptor (CB1) sequences and a full-length clone was isolated by screening of a human genomic DNA library. This gene, termed EDG-3, is highly homologous (51.9 % overall and 69.2 % in seven transmembrane regions) to human...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi F,Tokuda M,Hatase O,Brenner S

更新日期：1996-10-14 00:00:00

abstract：:The cellular response to DNA damage induced by gamma-irradiation activates cell-cycle arrest to permit DNA repair and to prevent replication. Cyclin D1 is the key molecule for transition between the G1 and S phases of the cell-cycle, and amplification or overexpression of cyclin D1 plays pivotal roles in the developme...

journal_title：Biochemical and biophysical research communications

authors： Choo DW,Baek HJ,Motoyama N,Cho KH,Kim HS,Kim SS

更新日期：2009-01-23 00:00:00

abstract：:SARS-like coronavirus (SL-CoV) in bats have a similar genomic organization to the human SARS-CoV. Their cognate gene products are highly conserved with the exception of the N-terminal region of the S proteins, which have only 63-64% sequence identity. The N-terminal region of coronavirus S protein is responsible for v...

journal_title：Biochemical and biophysical research communications

authors： Zhou P,Han Z,Wang LF,Shi Z

更新日期：2009-09-18 00:00:00

abstract：:Tyrosine kinase inhibitors (TKIs) exert potent therapeutic efficacy in non-small cell lung cancers (NSCLC) harboring epidermal growth factor receptor (EGFR) activating mutations. However, a major impediment for the effective treatment is the development of drug resistance. Some evidence supports a role for miRNAs in m...

journal_title：Biochemical and biophysical research communications

authors： Ping W,Gao Y,Fan X,Li W,Deng Y,Fu X

更新日期：2018-01-22 00:00:00

abstract：:Sheep thyroid cells cultured in serum-free medium were used to study the biologic activity, binding, and production of the insulin-like growth factors (IGFs). IGF-I, IGF-II, and insulin stimulated thyroid cell division. Abundant, specific IGF receptors on sheep thyroid cell membranes were identified by binding displac...

journal_title：Biochemical and biophysical research communications

authors： Bachrach LK,Eggo MC,Hintz RL,Burrow GN

更新日期：1988-08-15 00:00:00

abstract：:beta-Amyloid (Abeta) is the primary protein component of senile plaques in Alzheimer's disease (AD) and has been implicated in neurotoxicity associated with the disease. Abeta aggregates readily in vitro and in vivo, and its toxicity has been linked to its aggregation state. Prevention of Abeta aggregation has been in...

journal_title：Biochemical and biophysical research communications

authors： Lee S,Carson K,Rice-Ficht A,Good T

更新日期：2006-08-25 00:00:00

abstract：:In the present study, we tested the anti-pancreatic cancer activity by AT406, a small-molecule antagonist of IAP (inhibitor of apoptosis proteins). In established (Panc-1 and Mia-PaCa-2 lines) and primary human pancreatic cancer cells, treatment of AT406 significantly inhibited cell survival and proliferation. Yet, sa...

journal_title：Biochemical and biophysical research communications

authors： Jiang Y,Meng Q,Chen B,Shen H,Yan B,Sun B

更新日期：2016-09-09 00:00:00

abstract：:Hepatocytes cultured on type I collagen proliferate in response to mitogenic growth factors yet de-differentiate. By contrast, hepatocytes on laminin-rich gels (EHS) demonstrate stable differentiated functions, while DNA synthesis is negligible. Here we have confirmed that this lack of proliferation was not due to det...

journal_title：Biochemical and biophysical research communications

authors： Gardner MJ,Fletcher K,Pogson CI,Strain AJ

更新日期：1996-11-12 00:00:00

abstract：:The inhibitory effect of mercapto- and chlorodicarbanonaborates on mitochondrial, FAD-linked, L-glycerol-3-phosphate dehydrogenase activity was tested. The mercaptodicarbanonaborate was found to be a more potent inhibitor than the chloro derivative. The Ki of mercapto- and chlorodicarbanonaborates were 0.8 M and 480 M...

journal_title：Biochemical and biophysical research communications

authors： Drahota Z,Saf P,Rauchová H,Kalous M

更新日期：1995-05-25 00:00:00

abstract：:Using minimum energy calculations and molecular dynamics techniques the preferred conformational states of LHRH and its analogues have been reported to involve a modified beta-bend between residues 5 to 8. Based on some of these models cyclic peptide analogues of LHRH antagonists were synthesised using solid phase pep...

journal_title：Biochemical and biophysical research communications

authors： Dutta AS,Gormley JJ,McLachlan PF,Woodburn JR

更新日期：1989-03-31 00:00:00