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NF90 regulates PARP1 mRNA stability in hepatocellular carcinoma.

Abstract：

:Poly (ADP-ribose) polymerase 1 (PARP1) is an ADP- ribosylation enzyme and plays important roles in a variety of cellular processes, including DNA damage response and tumor development. However, the post-transcriptional regulation of PARP1 remains largely unknown. In this study, we identified that the mRNA of PARP1 is associated with nuclear factor 90 (NF90) by RNA immunoprecipitation plus sequencing (RIP-seq) assay. The mRNA and protein levels of PARP1 are dramatically decreased in NF90-depleted cells, and NF90 stabilizes PARP1's mRNA through its 3'UTR. Moreover, the expression levels of PARP1 and NF90 are positively correlated in hepatocellular carcinoma (HCC). Finally, we demonstrated that NF90-depleted cells are sensitive to PARP inhibitor Olaparib (AZD2281) and DNA damage agents. Taken together, these results suggest that NF90 regulates PARP1 mRNA stability in hepatocellular carcinoma cells, and NF90 is a potential target to inhibit PARP1 activity.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Song D,Huang H,Wang J,Zhao Y,Hu X,He F,Yu L,Wu J

doi

10.1016/j.bbrc.2017.05.037

subject

Has Abstract

pub_date

2017-06-17 00:00:00

pages

211-217

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(17)30896-3

journal_volume

488

pub_type

杂志文章

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