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Artificial regulation of p53 function by modulating its assembly.

Abstract：

:The tumor suppressor p53, a 393-amino acid transcription factor with four domains, induces cell cycle arrest, senescence, and apoptosis in response to diverse stress. Tetramer formation is critical for the function of p53. The tetramerization domain permits the tetramerization of p53, where bundled four DNA-binding domains recognize the specific target DNA sequences and activate hundreds of genes, which lead to the various cell fates. Here we show that tumor suppressive functions of p53 can be regulated by manipulating tetramer formation of an engineered p53, in which tetramerization domain of p53 is replaced with an inducible tetramer forming protein. This result suggests that artificial regulation of p53 activity by the engineered p53 is a useful tool to investigate the tumor suppression mechanism of p53 and to combat cancer.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Inobe T,Nozaki M,Nukina N

doi

10.1016/j.bbrc.2015.09.162

subject

Has Abstract

pub_date

2015-11-13 00:00:00

pages

322-7

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(15)30694-X

journal_volume

467

pub_type

杂志文章

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