Acyl-trafficking in membrane phospholipid fatty acid turnover: the transfer of fatty acid from the acyl-L-carnitine pool to membrane phospholipids in intact human erythrocytes.

abstract：:Lung cancer is the leading cause of cancer deaths. Epidermal growth factor receptor (EGFR) kinase domain mutations are a common cause of non-small cell lung cancers (NSCLCs), a major subtype of lung cancers. Patients harboring most of these mutations respond well to the anti-EGFR tyrosine kinase inhibitors (TKIs) gefi...

journal_title：Biochemical and biophysical research communications

authors： Zhao P,Yao MY,Zhu SJ,Chen JY,Yun CH

更新日期：2018-07-20 00:00:00

abstract：:Adipogenesis is the process of differentiation from preadipocytes to adipocytes and is orchestrated by various transcription factors, such as the peroxisome proliferator-activated receptor gamma (PPARγ) and the CCAAT-enhancer-binding protein alpha (C/EBPα). Oxidative stress is also a crucial factor in adipogenesis, an...

journal_title：Biochemical and biophysical research communications

authors： Kim BR,Lee GY,Yu H,Maeng HJ,Oh TJ,Kim KM,Moon JH,Lim S,Jang HC,Choi SH

更新日期：2018-03-18 00:00:00

abstract：:Chikungunya is a severe disease that results from infection with the chikungunya virus (CHIKV), an arbovirus. Thus, we (1) explored a new approach to combining previously researched drugs that have shown the potential to inhibit CHIKV infection; and (2) demonstrated the antiviral effects of (-)-Epigallocatechin-3-gall...

journal_title：Biochemical and biophysical research communications

authors： Lu JW,Hsieh PS,Lin CC,Hu MK,Huang SM,Wang YM,Liang CY,Gong Z,Ho YJ

更新日期：2017-09-23 00:00:00

abstract：:In the present study, we investigated if Cl(-) regulates the proliferation of the MC3T3-E1 osteoblastic cells. The proliferation of MC3T3-E1 osteoblastic cells was diminished by lowering the extracellular Cl(-) concentration ([Cl(-)](o)) in the culture medium. The lowered in [Cl(-)](o) increased the periods of the G(0...

journal_title：Biochemical and biophysical research communications

authors： Maki M,Miyazaki H,Nakajima K,Yamane J,Niisato N,Morihara T,Kubo T,Marunaka Y

更新日期：2007-10-05 00:00:00

abstract：:To study the effect of interleukin-6 (IL-6) on glucose transport, 2-deoxy-D-glucose (2-DOG) uptake in 3T3-L1 adipocytes after incubation with IL-6 was measured. IL-6 increased 2-DOG uptake maximally after 5 hours by 30 +/- 12%, with a half-maximal effect at an IL-6 concentration of approximately 800 U/mL. 3-O-methylgl...

journal_title：Biochemical and biophysical research communications

authors： Stouthard JM,Oude Elferink RP,Sauerwein HP

更新日期：1996-03-18 00:00:00

abstract：:Many proteins exhibit strong binding affinities to surfaces, with binding energies much greater than thermal fluctuations. When modelling these protein-surface systems with classical molecular dynamics (MD) simulations, the large forces that exist at the protein/surface interface generally confine the system to a sing...

journal_title：Biochemical and biophysical research communications

authors： Prakash A,Sprenger KG,Pfaendtner J

更新日期：2018-03-29 00:00:00

abstract：:Drug-induced hepatotoxicity causes significant morbidity and mortality and is a major concern in drug development. This is due, in large part, to insufficient knowledge of the mechanism(s) of drug-induced liver injury. In order to address this problem, we have evaluated the modulation of gene expression within the liv...

journal_title：Biochemical and biophysical research communications

authors： Reilly TP,Bourdi M,Brady JN,Pise-Masison CA,Radonovich MF,George JW,Pohl LR

更新日期：2001-03-23 00:00:00

abstract：:Cytochrome P450 3A4, the most abundant P450 form in human liver, exhibits a very broad substrate specificity and is of great importance for drug metabolism. The interindividual difference in the hepatic expression of CYP3A4 is considerable. In order to investigate possible genetic factor(s) causing this variation, the...

journal_title：Biochemical and biophysical research communications

authors： Westlind A,Löfberg L,Tindberg N,Andersson TB,Ingelman-Sundberg M

更新日期：1999-05-27 00:00:00

abstract：:Posttranslational histone modifications play an important role in modulating gene expression and chromatin structure. Here we report the identification of histone H3K79 dimethylation in the simple eukaryote Dictyostelium discoideum. We have deleted the D. discoideum Dot1/KMT4 homologue and demonstrate that it is the s...

journal_title：Biochemical and biophysical research communications

authors： Müller-Taubenberger A,Bönisch C,Fürbringer M,Wittek F,Hake SB

更新日期：2011-01-28 00:00:00

abstract：:A mitochondrial DNA mutation at nucleotide position 14,484 was found in 14 independent probands with Leber hereditary optic neuropathy and in 0/250 controls. The 14,484 mutation, which changes methionine-64 to valine in a conserved domain of the ND-6 gene, occurred in association with a mitochondrial DNA haplotype tha...

journal_title：Biochemical and biophysical research communications

authors： Johns DR,Neufeld MJ,Park RD

更新日期：1992-09-30 00:00:00

abstract：:By searching the zebrafish expressed sequence tag (EST) database, we have identified a cDNA clone encoding a putative zebrafish cytosolic sulfotransferase (ST). This cDNA was isolated and subjected to nucleotide sequencing. Analysis of the sequence data revealed that this novel zebrafish ST displays 32-35% amino acid ...

journal_title：Biochemical and biophysical research communications

authors： Sugahara T,Liu CC,Govind Pai T,Liu MC

更新日期：2003-01-17 00:00:00

abstract：:A protein, with a novel N-terminal amino acid sequence and a molecular mass of 30 kDa, was purified from fresh Smilax glabra rhizomes by adsorption on DEAE-cellulose, CM-cellulose, Con A-Sepharose, and Mono S, and by fast protein liquid chromatography-gel filtration on Superdex 75. The protein, designated as smilaxin,...

journal_title：Biochemical and biophysical research communications

authors： Chu KT,Ng TB

更新日期：2006-02-03 00:00:00

abstract：:Inactivation of serotonin transporter (HTT) by pharmacologically in the neonate or genetically increases risk for depression in adulthood, whereas pharmacological inhibition of HTT ameliorates symptoms in depressed patients. The differing role of HTT function during early development and in adult brain plasticity in c...

journal_title：Biochemical and biophysical research communications

authors： Ichikawa M,Okamura-Oho Y,Shimokawa K,Kondo S,Nakamura S,Yokota H,Himeno R,Lesch KP,Hayashizaki Y

更新日期：2008-03-28 00:00:00

abstract：:The mitochondrial respiratory chain (MRC) supplies the majority of the energy requirements of most eucaryotic cells. A null mutation in the Caenorhabditis elegans nuo-1 gene encoding a subunit of complex I (NADH-ubiquinone oxidoreductase) is lethal, leading to a developmental arrest at the third larval stage. To ident...

journal_title：Biochemical and biophysical research communications

authors： Ndegwa S,Lemire BD

更新日期：2004-07-09 00:00:00

abstract：AIMS:diabetes mellitus is one of the most common metabolic diseases worldwide characterized by insulin resistance and pancreatic β cell dysfunction. miRNA plays an important role in DM. In previous studies, miRNA-92a could function as targets for innovative precision medicines to reduce T1D islet autoimmunity. However,...

journal_title：Biochemical and biophysical research communications

authors： Wang W,Wang J,Yan M,Jiang J,Bian A

更新日期：2018-06-07 00:00:00

abstract：:Concomitant with the depletion of glutathione content, phorone (250 mg/kg, ip.) produced a marked increase in heme oxygenase activity, biphasic effect on delta-aminolevulinic acid synthetase activity, and slight decreases in cytochrome P-450 content and aminopyrine demethylase activity in the liver of rats. The increa...

journal_title：Biochemical and biophysical research communications

authors： Yoshida T,Oguro T,Numazawa S,Kuroiwa Y

更新日期：1987-05-29 00:00:00

abstract：:Innate immune cells respond to microbial invaders using pattern recognition receptors that detect conserved microbial patterns. Among the cellular processes stimulated downstream of pattern recognition machinery is the initiation of autophagy, which plays protective roles against intracellular microbes. We have shown ...

journal_title：Biochemical and biophysical research communications

authors： Pflaum K,Gerdes K,Yovo K,Callahan J,Snyder ML

更新日期：2012-06-08 00:00:00

abstract：:We show that a histone deacetylase (HDAC) inhibitor apicidin increases the transcriptional activity of cyclin E gene, which results in accumulation of cyclin E mRNA and protein in a time- and dose-dependent manner. Interestingly, apicidin induction of cyclin E gene is found to be mediated by Sp1- rather than E2F-bindi...

journal_title：Biochemical and biophysical research communications

authors： Kim S,Kang JK,Kim YK,Seo DW,Ahn SH,Lee JC,Lee CH,You JS,Cho EJ,Lee HW,Han JW

更新日期：2006-04-21 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have generated a great deal of interest in clinical situations, due principally to their potential use in regenerative medicine and tissue engineering applications. However, the therapeutic application of MSCs remains limited, unless the favorable effects of MSCs on tumor growth in vivo, ...

journal_title：Biochemical and biophysical research communications

authors： Shin KK,Lee AL,Kim JY,Lee SY,Bae YC,Jung JS

更新日期：2012-06-15 00:00:00

abstract：:A histidine-tagged recombinant N-terminal fragment of type-1 mouse liver diacylglycerol acyltransferase (DGAT; EC 2.3.1.20), MmDGAT1(1-95)His6, was expressed in Escherichia coli, and used to investigate possible acyl-CoA-binding properties. Analysis of the purified fragment by MALDI-TOF mass spectrometry revealed a po...

journal_title：Biochemical and biophysical research communications

authors： Siloto RM,Madhavji M,Wiehler WB,Burton TL,Boora PS,Laroche A,Weselake RJ

更新日期：2008-08-29 00:00:00

abstract：:A novel DNA sequence belonging to a new genotype of TT virus (TTV) was detected by long-distance PCR in the serum of a chronically HCV-infected patient. The isolate was designated KAV according to the patient's initials. Extending the sequence to full length revealed a 3705-nt viral genome, which is about 100 nucleoti...

journal_title：Biochemical and biophysical research communications

authors： Heller F,Zachoval R,Koelzer A,Nitschko H,Froesner GG

更新日期：2001-12-21 00:00:00

abstract：:We have identified and characterized the novel human transmembrane protein 9 (TMEM9). TMEM9 encodes a 183 amino-acid protein that contains an N-terminal signal peptide, a single transmembrane region, three potential N-glycosylation sites, and three conserved cys-rich domains in the N-terminus, but no hitherto known fu...

journal_title：Biochemical and biophysical research communications

authors： Kveine M,Tenstad E,Døsen G,Funderud S,Rian E

更新日期：2002-10-04 00:00:00

abstract：:(6R)5,6,7,8 tetrahydrobiopterin (6-BH4) is an important cofactor in the regulation of melanogenesis in melanocytes, where it controls: (a) the supply of L-tyrosine from L-phenylalanine via phenylalanine hydroxylase, and (b) regulates directly dopaquinone formation from L-tyrosine via tyrosinase. 6-BH4 undergoes redox-...

journal_title：Biochemical and biophysical research communications

authors： Schallreuter KU,Büttner G,Pittelkow MR,Wood JM,Swanson NN,Körner C

更新日期：1994-10-14 00:00:00

abstract：:The present study was carried out to investigate the effects of Interleukin-1 (IL-1) on gastric pepsin secretion in conscious pylorus-ligated rats. The intraperitoneal (ip) injection of IL-1 resulted in a dose-related inhibition of gastric pepsin output. The intracerebroventricular (icv) injection of IL-1 similarly re...

journal_title：Biochemical and biophysical research communications

authors： Okumura T,Uehara A,Okamura K,Takasugi Y,Namiki M

更新日期：1990-03-30 00:00:00

abstract：:Recently, we have shown that the thyrotropin (TSH) binding regions of human thyrotropin receptor (TSHR) reside in two areas within residues 12-44 and 308-344. Serial antisera were raised against four overlapping synthetic peptides representing these two regions of TSHR (peptides 12-30, 24-44, 308-328, and 324-344) and...

journal_title：Biochemical and biophysical research communications

authors： Sakata S,Ogawa T,Matsui I,Manshouri T,Atassi MZ

更新日期：1992-02-14 00:00:00

abstract：:Recently it has been shown that vascular endothelial cells (EC) are completely devoid of apoptosis if cultivated under a steady laminar flow and that apoptosis is induced by turning off the flow. An autocrine loop of thrombospondin-1 (TSP-1) and the alpha(v)beta(3) integrin/integrin-associated protein (IAP) complex ha...

journal_title：Biochemical and biophysical research communications

authors： Freyberg MA,Kaiser D,Graf R,Buttenbender J,Friedl P

更新日期：2001-08-10 00:00:00

abstract：:Efficiency of the induction protocol is crucial for the generation of insulin-producing cells (IPCs) from human dental pulp stem cells (hDPSCs). Here, we established the integrative induction protocol by merging genetic manipulation technique with our previous published 3-step induction protocol aiming to enhance the ...

journal_title：Biochemical and biophysical research communications

authors： Sawangmake C,Rodprasert W,Osathanon T,Pavasant P

更新日期：2020-09-10 00:00:00

abstract：:The effect of vitamin A supplementation on stearoyl-CoA desaturase gene 1 expression in mouse liver was characterized. Normal BALB/c mice were fed 0.01% and 0.1% retinol palmitate as components of nonpurified diets. This treatment resulted in a 3-fold and a 7-fold induction of SCD1 mRNA levels, respectively, as determ...

journal_title：Biochemical and biophysical research communications

authors： Miller CW,Waters KM,Ntambi JM

更新日期：1997-02-03 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Angiogenesis is reported to play a pivotal role in the occurrence, development and metastasis of HCC. The renin-angiotensin system (RAS) is involved in the regulation of angiogenesis. Here, based on the analysis of HCC datasets from Gene Expre...

journal_title：Biochemical and biophysical research communications

authors： Ye G,Qin Y,Lu X,Xu X,Xu S,Wu C,Wang X,Wang S,Pan D

更新日期：2015-03-27 00:00:00

abstract：:Expression of the human beta-myosin heavy chain (beta MHC) gene was studied by transient assay in culture and in situ by direct injection of plasmids into adult rat hearts. In this report we describe a unique repressor region located -326/-309 (5'-TTGGTGGTCGTGGTCAGT-3') of the human beta MHC gene that is conserved amo...

journal_title：Biochemical and biophysical research communications

authors： Edwards JG,Bahl JJ,Flink I,Milavetz J,Goldman S,Morkin E

更新日期：1992-11-30 00:00:00