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Homozygous deletions of the MTS1 gene are rare in non-astrocytic brain tumors.

Abstract：

:Several studies support a role for the multiple tumor suppressor gene (MTS1) in the malignant progression of different tumor types. In this study we have examined the status of the MTS1 gene in a variety of non-astrocytic tumors of the central nervous system. It was not possible, using multiplex PCR with primers for MTS1 and D9S196, a chromosome 9q marker, to demonstrate deletions of MTS1 in 59 primary non-astrocytic tumors. Two out of 5 (40%) secondary tumors showed evidence of homozygous deletion of MTS1. The results obtained here for primary non-astrocytic tumors contrast with those previously described for astrocytic tumors where a high frequency of deletions of MTS1 was associated with tumor progression.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Walker DG,Duan W,Kaye AH,Lavin MF

doi

10.1006/bbrc.1995.1828

subject

Has Abstract

pub_date

1995-06-15 00:00:00

pages

404-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006291X85718281

journal_volume

211

pub_type

杂志文章

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