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Molecular cloning of Ebitein1: a novel extracellular signal-regulated kinase 2-binding protein in testis.

Abstract：

:We cloned a cDNA encoding a novel extracellular signal-regulated kinase (ERK) 2-binding protein, EBITEIN1, by yeast two-hybrid screening. Northern and Western blotting experiments showed that the transcript and protein were expressed in the testes. Furthermore, immunohistochemical experiments showed that EBITEIN1 existed at high levels in round spermatids, but at very low levels or not at all in other testicular cells. During spermatogenesis, EBITEIN1 was first translated after meiosis when cells became haploid, then the amount of EBITEIN1 protein gradually increased, reaching a maximum at Oakberg's stage 9. Subsequently, the level of EBITEIN1 decreased such that it was undetectable when the flagellum of the spermatozoon was generated. On a subcellular level, EBITEIN1 localized in the cytoplasm. Based on these results, we propose that EBITEIN1 is an interactor of ERK2 in the intracellular signal transduction pathway that occurs during the morphogenetic development of round spermatids to spermatozoa. The existence of this novel ERK2-interactor indicates that there could be a novel intracellular signaling pathway and/or regulatory mechanism by which ERK2 regulates intracellular events.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Miura K,Imaki J

doi

10.1016/j.bbrc.2008.01.078

subject

Has Abstract

pub_date

2008-04-04 00:00:00

pages

336-42

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)00123-X

journal_volume

368

pub_type

杂志文章

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