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Cationic amphiphilic drugs perturb the metabolism of inosititides and phosphatidic acid in photoreceptor membranes.

Abstract：

:Incubation of purified bovine photoreceptor rod outer segments with [gamma-32P]ATP resulted in the labeling of phosphatidylinositol 4-phosphate (PIP) and phosphatidic acid (PA) with little labeling of phosphatidylinositol 4,5-bisphosphate (PIP2). Propranolol inhibited in a dose-dependent manner the labeling of PA and enhanced that of PIP. Various cationic amphiphilic drugs also were tested for these effects. Propranolol had the same effects on high-speed rat brain particulate material. While this particular preparation displayed more labeling of PIP2, propranolol was ineffective, as it was on retinal PIP-kinase. Ca2+-activated polyphosphoinositide phosphodiesterase activity in nerve-ending membranes also was inhibited by propranolol. It is concluded that cationic amphiphilic drugs can inhibit diacylglycerol kinase and the polyphosphoinositide phosphodiesterase and stimulate the phosphatidylinositol-kinase (but not PIP-kinase).

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Van Rooijen LA,Bazan NG

doi

10.1016/0006-291x(86)90574-7

subject

Has Abstract

pub_date

1986-01-14 00:00:00

pages

378-85

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(86)90574-7

journal_volume

134

pub_type

杂志文章

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