Global cerebral ischemia induces increased expression of multiple retrotransposons.

Abstract:

:Retrotransposons (RTs) account for ~45% of the mammalian genome. They are capable of inserting into new genomic locations, which can result in deleterious outcomes. We examined the response of nine RTs to global cerebral ischemia (GCI) and explored the DNA methylation status of the two significantly altered RTs. Seven of the nine RTs were significantly increased at 24h post-insult in ischemic hippocampus. GCI also led to a significant decrease in the DNA methylation status of intracisternal A-particle (IAP) RT, but had no marked effect upon DNA methylation of long interspersed nucleotide element 1 (L1) RT. In summary, GCI produced marked increases in RT RNA expression and had a differential effect on the DNA methylation status of two RTs in vulnerable hippocampal neurons destined to die. These data suggest that RTs may play an active role in ischemic brain pathology and that these endogenous mutagens and their regulatory elements could be targeted as potential therapeutic targets in this devastating condition.

authors

Wang S,Kelly S

doi

10.1016/j.bbrc.2013.03.116

subject

Has Abstract

pub_date

2013-05-10 00:00:00

pages

572-6

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(13)00595-0

journal_volume

434

pub_type

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