Urocortin: a beneficial or detrimental agent to endothelium?

abstract：:Three different domains of human sperm membrane, viz., the hydrophobic domains, the aqueous compartments and the surface proteins were probed to evaluate the molecular dynamics in these microenvironments in normal as well as oligospermic cases. Decreased rotational motion of the stearic spin-labels, designated rigid l...

journal_title：Biochemical and biophysical research communications

authors： Sinha S,Kumar GP,Laloraya M

更新日期：1994-01-14 00:00:00

abstract：:The present study was designed to clarify the cellular localization and expression of leptin receptor(s) [OB-R(s)] mRNA including its splice variants and their correlation with the cells which secrete placental hormone, placental lactogen-II (PL-II), in rat placentae. By in situ hybridization analysis, hybridization s...

journal_title：Biochemical and biophysical research communications

authors： Kawai M,Murakami T,Otani S,Shima K,Yamaguchi M,Kishi K

更新日期：1999-04-13 00:00:00

abstract：:Difluoromethylornithine (DFMO) depletes cells of polyamines, sensitizing cells against the action of antineoplastic drugs and altering ability to repair radiation-induced DNA strand breaks. Others have hypothesized that the mechanism by which polyamine depletion sensitizes cells is through inhibition of DNA strand bre...

journal_title：Biochemical and biophysical research communications

authors： Williams JR,Casero RA,Dillehay LE

更新日期：1994-05-30 00:00:00

abstract：:Interleukin-1 alpha induced an increase in both the cellular accumulation of cis-diamminedichloroplatinum (II) (cisplatin) and DNA platination and significantly reduced the removal of platinum from DNA of human ovarian (NIH: OVCAR-3) carcinoma cells in culture. The combinations of IL-1 alpha and cisplatin were highly ...

journal_title：Biochemical and biophysical research communications

authors： Benchekroun MN,Parker R,Reed E,Sinha BK

更新日期：1993-08-31 00:00:00

abstract：:A novel human gene containing an ankyrin repeat and BTB/POZ domains (BPOZ) was isolated from a human leukocyte cDNA library. The cDNA sequence contains an open reading frame of 1434 bp that encodes 478 amino acid residues with a predicted molecular mass of 53.9 kDa. Sequence pattern analysis shows that BPOZ contains a...

journal_title：Biochemical and biophysical research communications

authors： Dai KS,Wei W,Liew CC

更新日期：2000-07-14 00:00:00

abstract：:The proliferation of colon cancer cells is mediated in part by epidermal growth factor receptor (EGFR) signaling and requires sustained levels of cellular energy to meet its high metabolic needs. Intracellular lipid droplets (LDs) are a source of energy used for various cellular functions and they are elevated in dens...

journal_title：Biochemical and biophysical research communications

authors： Penrose H,Heller S,Cable C,Makboul R,Chadalawada G,Chen Y,Crawford SE,Savkovic SD

更新日期：2016-01-15 00:00:00

abstract：:Myocardial ischemia/reperfusion (I/R) still have high morbidity and mortality worldwide. Platelet activating factor (PAF) is a potent phospholipid regulator of inflammation. PAF acts on a single receptor (PAFR), which is expressed on cellular and nuclear membranes of various cell types. The study is aimed to explore i...

journal_title：Biochemical and biophysical research communications

authors： Wang EW,Han YY,Jia XS

更新日期：2018-01-22 00:00:00

abstract：:Interleukin (IL)-18 bioactivity and dsRNA sensing by receptors of innate immunity are key components of anti-viral host defense. Despite extensive data on signal transduction activated by both pathways knowledge on cross-communication is incomplete. By using human PBMC and predendritic KG1 cells, as prototypic IL-18-r...

journal_title：Biochemical and biophysical research communications

authors： Balah A,Akool el-S,Bachmann M,Pfeilschifter J,Mühl H

更新日期：2009-11-27 00:00:00

abstract：:We provide the first demonstration for a Na+/Ca2+ exchanger, NCX-1, in the osteoclast. We speculate that by using Na+ exchange, NCX-1 couples H+ extrusion with Ca2+ fluxes during bone resorption. Microspectrofluorimetry of fura-2-loaded osteoclasts revealed a rapid and sustained, but reversible, cytosolic Ca2+ elevati...

journal_title：Biochemical and biophysical research communications

authors： Moonga BS,Davidson R,Sun L,Adebanjo OA,Moser J,Abedin M,Zaidi N,Huang CL,Zaidi M

更新日期：2001-05-18 00:00:00

abstract：:The products of the human hepatitis B virus (HBV) and woodchuck hepatitis B virus X genes (pXs) transactivate homologous and heterologous genes including the HBV-X and core promoters, the human immunodeficiency viruses 1 (HIV-1) and 2 (HIV-2) long terminal repeats and the beta interferon regulatory sequences. We repor...

journal_title：Biochemical and biophysical research communications

authors： Balsano C,Avantaggiati ML,Natoli G,De Marzio E,Will H,Perricaudet M,Levrero M

更新日期：1991-05-15 00:00:00

abstract：:The crypt-villi axis of intestinal mucosa maintains homeostasis by renewal of epithelia, and also exhibits different properties from undifferentiated to terminally differentiated cells. We investigated differential susceptibility to genotoxin-induced cell death, based on the degree of differentiation of epithelial cel...

journal_title：Biochemical and biophysical research communications

authors： Chae B,Yang KM,Kim TI,Kim WH

更新日期：2009-01-23 00:00:00

abstract：:Polycystin-1 (PC1) is a membrane protein expressed in tubular epithelia of developing kidneys and in other ductal structures. Recent studies indicate this protein to be putatively important in regulating intracellular Ca(2+) levels in various cell types, but little evidence exists for kidney epithelial cells. Here we ...

journal_title：Biochemical and biophysical research communications

authors： Aguiari G,Campanella M,Manzati E,Pinton P,Banzi M,Moretti S,Piva R,Rizzuto R,del Senno L

更新日期：2003-02-14 00:00:00

abstract：:Human Gb3/CD77 synthase (α1,4-galactosyltransferase, P(k) synthase), encoded by A4GALT gene, is known for synthesis of Gal(α1-4)Gal moiety in globotriaosylceramide (Gb3Cer, CD77, P(k) blood group antigen), a glycosphingolipid of the globo series. Recently, it was shown that c.631C > G mutation in A4GALT, which causes ...

journal_title：Biochemical and biophysical research communications

authors： Kaczmarek R,Duk M,Szymczak K,Korchagina E,Tyborowska J,Mikolajczyk K,Bovin N,Szewczyk B,Jaskiewicz E,Czerwinski M

更新日期：2016-01-29 00:00:00

abstract：:We previously demonstrated that pleiotrophin (PTN the protein, Ptn the gene) highly regulates the levels of expression of the genes encoding the proteins of the renin-angiotensin pathway in mouse aorta. We now demonstrate that the levels of expression of these same genes are significantly regulated in mouse aorta by t...

journal_title：Biochemical and biophysical research communications

authors： Ezquerra L,Herradon G,Nguyen T,Silos-Santiago I,Deuel TF

更新日期：2005-07-29 00:00:00

abstract：:Steatosis is an important clinical manifestation of hepatitis C virus (HCV) infection. The molecular mechanisms of HCV-associated steatosis are not well understood. Sterol regulatory element-binding protein-1c (SREBP-1c) is a key transcription factor which activates the transcription of lipogenic genes. Here we showed...

journal_title：Biochemical and biophysical research communications

authors： Xiang Z,Qiao L,Zhou Y,Babiuk LA,Liu Q

更新日期：2010-11-19 00:00:00

abstract：:Targeted drug delivery has been an important issue for tumor therapy including photodynamic therapy (PDT). The purpose of our study is to increase the targeting efficiency of photosensitizer (PS) using folate-modified nanoparticles (NPs) to tumor site in vivo. Folate receptor is over-expressed on the surface of many h...

journal_title：Biochemical and biophysical research communications

authors： Son J,Yang SM,Yi G,Roh YJ,Park H,Park JM,Choi MG,Koo H

更新日期：2018-04-06 00:00:00

abstract：:In the early postnatal period, cerebellar granule cells exhibit an activity-dependent downregulation of a set of immaturation genes involved in cell growth and migration and are shifted to establishment of a mature network formation. Through the use of a granule cell culture and both pharmacological and RNA interferen...

journal_title：Biochemical and biophysical research communications

authors： Okazawa M,Abe H,Nakanishi S

更新日期：2016-05-13 00:00:00

abstract：:Glycogen synthase kinase (GSK)-3β interaction protein (GSKIP), a key regulator of signaling transduction, is implicated in multiple pathological processes. However, whether GSKIP is involved in myocardial infarction is unknown. The present study was designed to determine the potential involvement of GSKIP in myocardia...

journal_title：Biochemical and biophysical research communications

authors： Yan L,Cheng G,Yang G

更新日期：2020-10-29 00:00:00

abstract：:A protein of M(r) 59,000 (p59) was recently cloned and identified as a Heat shock protein Binding Immunophilin (p59/HBI). It participates to the heterooligomeric, non-DNA binding form of steroid receptors, in association with the heat shock protein of M(r) 90,000 (hsp90). It binds the immunosuppressants FK506 and rapa...

journal_title：Biochemical and biophysical research communications

authors： Le Bihan S,Renoir JM,Radanyi C,Chambraud B,Joulin V,Catelli MG,Baulieu EE

更新日期：1993-09-15 00:00:00

abstract：:Chorea-acanthocytosis (ChAc) is a hereditary neurodegenerative disorder caused by loss of function mutations in the VPS13A gene encoding chorein. Recently, using a gene-targeting technique to delete exons 60-61, we produced a ChAc-model mouse that corresponds to a human disease mutation. In this study, a comparative m...

journal_title：Biochemical and biophysical research communications

authors： Kurano Y,Nakamura M,Ichiba M,Matsuda M,Mizuno E,Kato M,Izumo S,Sano A

更新日期：2006-12-15 00:00:00

abstract：:Incorporation of [3H]-thymidine into DNA in non-synchronized cultures of human endothelial cells was blocked by a 24 h exposure to TNF in a dose dependent manner that resulted in accumulation of cells in G1, as assayed by flow cytometry analysis of DNA content. Proliferation restarted when cells were replated in the a...

journal_title：Biochemical and biophysical research communications

authors： López-Marure R,Bernal AE,Zentella A

更新日期：1997-07-30 00:00:00

abstract：:BRCA1-associated protein 1 (BAP1) has been implicated in diverse biological functions, including tumor suppression. However, its regulation via glycosylation and its role in embryonic stem (ES) cells are poorly defined. BAP1 was recently reported to interact with O-linked N-acetylglucosamine (O-GlcNAc) transferase (OG...

journal_title：Biochemical and biophysical research communications

authors： Moon S,Lee YK,Lee SW,Um SJ

更新日期：2017-10-07 00:00:00

abstract：:We have constructed a highly useful phage-displayed human antibody repertoire with limited cloning efforts. Our strategy was to maximize diversity during the first steps of library construction through the use of various lymphoid sources from several donors, inclusion of different immunoglobulin isotypes, and performa...

journal_title：Biochemical and biophysical research communications

authors： Rojas G,Lamdan H,Padron S,Munoz Y,Ayala M,Gavilondo JV

更新日期：2005-11-04 00:00:00

abstract：:The developing and the adult brain respond in similar ways to ischemia, but also display clear differences. For example, the relative contributions of necrosis and apoptosis to neuronal death may be different, such that apoptotic mechanisms would be more prevalent in the developing brain. During normal development, mo...

journal_title：Biochemical and biophysical research communications

authors： Blomgren K,Zhu C,Hallin U,Hagberg H

更新日期：2003-05-09 00:00:00

abstract：:Nuclei of the dorsolateral prostate of rats contain a large amount of androgen-dependent non-histone protein (20K-NHP) (mol. wt. not equal to 20,000; pI not equal to 11.5) (Matuo et al. (1]. Its content in the nuclei increased most markedly during 4-8 weeks of age, when functional differentiation of the prostate was m...

journal_title：Biochemical and biophysical research communications

authors： Matuo Y,Nishi N,Tanaka Y,Muguruma Y,Tanaka K,Akatsuka Y,Matsui SI,Sandberg AA,Wada F

更新日期：1984-01-30 00:00:00

abstract：:The binding of the leucocyte adhesion molecule L-selectin has been investigated toward several structurally defined lipid-linked oligosaccharides immobilized on silica gel chromatograms or plastic wells. In both assay systems the 3'-sulphated Le(a)/Le(x) type tetrasaccharides [formula: see text] were more strongly bou...

journal_title：Biochemical and biophysical research communications

authors： Green PJ,Tamatani T,Watanabe T,Miyasaka M,Hasegawa A,Kiso M,Yuen CT,Stoll MS,Feizi T

更新日期：1992-10-15 00:00:00

abstract：:PQBP-1 was identified as a binding protein to the polyglutamine tract present in various transcription-related factors and causative genes for neurodegenerative disorders. This novel gene contains at least two functional domains, WW domain and carboxyl-terminal domain (CTD), strictly conserved beyond species. Although...

journal_title：Biochemical and biophysical research communications

authors： Waragai M,Junn E,Kajikawa M,Takeuchi S,Kanazawa I,Shibata M,Mouradian MM,Okazawa H

更新日期：2000-07-05 00:00:00

abstract：:A common cause for pharmacogenetic alteration in drug response is genetic variation in encoded amino acid sequence. We have used the catecholamine and drug-metabolizing enzyme sulfotransferase (SULT)1A3 to create an artificial model system to study mechanisms-especially possible aggresome formation-by which genetic al...

journal_title：Biochemical and biophysical research communications

authors： Wang L,Yee VC,Weinshilboum RM

更新日期：2004-12-10 00:00:00

abstract：:Zinc is an essential element for the biological system. However, excessive exogenous Zn2+ would disrupt cellular Zn2+ homeostasis and cause toxicity. In particular, Zinc salts or ZnO nanoparticles exposure could induce respiratory injury. Although previous studies have indicated that organelle damage (including mitoch...

journal_title：Biochemical and biophysical research communications

authors： Qin X,Zhang J,Wang B,Xu G,Zou Z

更新日期：2017-06-17 00:00:00

abstract：:The sulfhydryl group reagent N-ethylmaleimide was found to inhibit in a dose dependent manner regulatory volume decrease of human peripheral lymphocytes swollen in buffered hyposmotic NaCl media. In hyposmotic KCl media NEM treated lymphocytes prevented an additional secondary swelling seen in control lymphocytes. The...

journal_title：Biochemical and biophysical research communications

authors： Bauer J,Lauf PK

更新日期：1983-11-30 00:00:00