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Changes of an androgen-dependent nuclear protein during functional differentiation and by dedifferentiation of the dorsolateral prostate of rats.

Abstract：

:Nuclei of the dorsolateral prostate of rats contain a large amount of androgen-dependent non-histone protein (20K-NHP) (mol. wt. not equal to 20,000; pI not equal to 11.5) (Matuo et al. (1]. Its content in the nuclei increased most markedly during 4-8 weeks of age, when functional differentiation of the prostate was most active on the basis of the changes of major cytosol proteins and zinc. Nuclei of the Dunning tumors originating in the dorsolateral prostate were found to lack 20K-NHP regardless of androgen dependency, indicating the disappearance of the 20K-NHP from the nuclei by dedifferentiation. These suggest that the 20K-NHP is an important nuclear protein for differentiation of the dorsolateral prostate cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Matuo Y,Nishi N,Tanaka Y,Muguruma Y,Tanaka K,Akatsuka Y,Matsui SI,Sandberg AA,Wada F

doi

10.1016/0006-291x(84)91326-3

subject

Has Abstract

pub_date

1984-01-30 00:00:00

pages

467-73

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(84)91326-3

journal_volume

118

pub_type

杂志文章

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