FBXO11 represses cellular response to hypoxia by destabilizing hypoxia-inducible factor-1α mRNA.


:The transcriptional factor hypoxia-inducible factor-1α (HIF-1α) is induced under hypoxia and plays crucial roles in cancer progression and angiogenesis. Protein arginine methyltransferases (PRMTs), 11 isoforms of which have been identified so far, modulates the functions of diverse proteins by catalyzing arginine methylation in post-translational level. PRMT9 (alternatively named FBXO11) and PRMT11 (FBXO10) are expected to have the E3 ubiquitin ligase activity through their F-box domains as well as the methyltrasferase activity. Given previous studies examining roles of 8 PRMT isoforms (PRMT1-8) in the HIF-1 signaling pathway, PRMT1 and PRMT5 were demonstrated to regulate HIF-1α expression in opposite ways. We herein examined if FBXO10 and FBXO11 participate in the HIF-1 signaling pathway. Consequently, the siRNA-mediated knockdown of FBXO11 facilitated HIF-1α expression in various cancer cells and HIF-1-driven gene expressions, but the FBXO10 knockdown did not. Mechanistically, FBXO11 was found to inhibit de novo synthesis of HIF-1α protein by destabilizing HIF-1α mRNA. Since a FBXO11 mutant lacking F-box failed to reverse the HIF-1α expression by FBXO11 knockdown, the FBXO11 regulation of HIF-1α may be attributed to the ubiquitination of some proteins controlling HIF-1α mRNA stability. Considering the oncogenic roles of HIF-1α, FBXO11 is suggested to act as a tumor suppressor and also to be a potential target for cancer therapy.


Ju UI,Park JW,Park HS,Kim SJ,Chun YS




Has Abstract


2015-09-04 00:00:00














  • Klenow exo-, as opposed to exo+, traverses through G-G:C triplex by melting G-G base pairs.

    abstract::G-G base-paired hairpin DNA structures on template strands offer potential "road-blocks" to a traversing polymerase. Klenow polymerase (exo+) pauses while replicating through G-G base-paired hairpin DNA due to the generation of G-G:C triplex. However, exonuclease-deficient Klenow traverses through de novo generated G-...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ramanathan S,Chary KV,Rao BJ

    更新日期:2002-07-19 00:00:00

  • The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling.

    abstract::Myocyte enhancer factor 2C (MEF2C) plays an important role in cardiovascular development and is a key transcription factor for cardiac hypertrophy. Here, we describe MEF2C regulation by insulin-like growth factor-1 (IGF-1) and its role in IGF-1-induced cardiac hypertrophy. We found that IGF-1 addition to cultured rat ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Muñoz JP,Collao A,Chiong M,Maldonado C,Adasme T,Carrasco L,Ocaranza P,Bravo R,Gonzalez L,Díaz-Araya G,Hidalgo C,Lavandero S

    更新日期:2009-10-09 00:00:00

  • Increased activity of c-Src and Csk in fibroblasts transformed by v-src oncogene.

    abstract::When c-Src and v-Src were immunoprecipitated together from hamster fibroblasts transformed by Rous sarcoma virus containing v-src oncogene, the total Src activity was almost threefold higher compared to c-Src activity in the control cells. The activity of v-Src immunoprecipitated separately, however, accounting for on...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Tuhácková Z,Vojtechová M,Hlavácek J,Ruzzene M,Sovová V,Pinna LA

    更新日期:2002-01-18 00:00:00

  • Inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin in hypopharyngeal carcinoma cells.

    abstract::Myeloid cell leukemia-1 (Mcl-1) plays an important role in survival, chemo- and radioresistance of head and neck squamous cell carcinoma (HNSCC). Cyclin-dependent kinase 9/cyclin T (CDK9) promotes excessive production of multiple pro-survival proteins including Mcl-1, leading to impaired apoptosis of cancer cells. As ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Cao S,Yu Y,Chen S,Lei D,Wang S,Pan X,Peng J

    更新日期:2017-01-22 00:00:00

  • Carnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction?

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Aldini G,Carini M,Beretta G,Bradamante S,Facino RM

    更新日期:2002-11-15 00:00:00

  • Regulation of autophagy and apoptosis in response to angiotensin II in HL-1 cardiomyocytes.

    abstract:BACKGROUND:Autophagy and apoptosis are two important regulators of cell survival, and are often observed simultaneously in response to noxious stimuli. Anoxia is a known stimulus for autophagy and apoptosis, and angiotensin (Ang) II is a major mediator of anoxic injury. However, specific responses to anoxia and Ang II ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Wang X,Dai Y,Ding Z,Khaidakov M,Mercanti F,Mehta JL

    更新日期:2013-11-01 00:00:00

  • LncRNA GSEC promotes the proliferation, migration and invasion by sponging miR-588/ EIF5A2 axis in osteosarcoma.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Liu R,Ju C,Zhang F,Tang X,Yan J,Sun J,Lv B,Guo Y,Liang Y,Lv XB,Zhang Z

    更新日期:2020-11-05 00:00:00

  • The C-terminal peptide of thrombospondin-4 stimulates erythroid cell proliferation.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Congote LF,Difalco MR,Gibbs BF

    更新日期:2004-11-12 00:00:00

  • A regulatory role of Kruppel-like factor 4 in endothelial argininosuccinate synthetase 1 expression in response to laminar shear stress.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Mun GI,Boo YC

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    abstract::Mouse hepatocytes were found to adhere much stronger to intact native type I collagen than to native, telopeptide-devoid collagen. Removal of telopeptides (by pepsin treatment) caused disintegration of supramolecular collagen aggregates. Similar differences in hepatocyte adhesion were observed between oligomeric and m...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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  • Inverse expression of two laminin binding proteins, 67LR and galectin-3, correlates with the invasive phenotype of trophoblastic tissue.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Iqbal M,Giri U,Athar M

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  • Inhibition of the mitochondrial phosphate carrier by a reaction with a carboxyl group reagent.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Wolf G,Genchi G,Palmieri F

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  • Characterization of a Smad motif similar to Drosophila mad in the mouse Msx 1 promoter.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Alvarez Martinez CE,Binato R,Gonzalez S,Pereira M,Robert B,Abdelhay E

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Yi HS,Pan CX,Pan C,Song J,Hu YF,Wang L,Pan MH,Lu C

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  • Processing of atriopeptin prohormone by nonmyocytic atrial cells.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Greenwald JE,Needleman P,Siegel N,Tetens E,Biel B,Ritter D

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  • G-quadruplex DNA and RNA: Their roles in regulation of DNA replication and other biological functions.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Masai H,Tanaka T

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  • Mouse lymphomas caused by an intron-splicing donor site deletion of the FasL gene.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Wang CC,Zeng Q,Hwang LA,Guo K,Li J,Liew HC,Hong W

    更新日期:2006-10-13 00:00:00

  • Lineage and stage specific expression of HOX 1 genes in the human hematopoietic system.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Vieille-Grosjean I,Roullot V,Courtois G

    更新日期:1992-03-31 00:00:00

  • Persistent BDNF exon I-IX mRNA expression following the withdrawal of neuronal activity in neurons.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Hara D,Miyashita T,Fukuchi M,Suzuki H,Azuma Y,Tabuchi A,Tsuda M

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Huang RY,Boulton SJ,Vidal M,Almo SC,Bresnick AR,Chance MR

    更新日期:2003-08-08 00:00:00

  • Heterogeneity of immunoreactive prolactin in the rat brain.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: DeVito WJ

    更新日期:1988-01-29 00:00:00

  • Cyclic adenosine 3',5'-monophosphate, a second messenger in interleukin-1 mediated K562 cytostasis.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Weitzmann MN,Savage N

    更新日期:1993-01-29 00:00:00

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Healy EF

    更新日期:2016-09-30 00:00:00

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Nagy I,Trexler M,Patthy L

    更新日期:2003-03-14 00:00:00

  • Telmisartan mitigates hyperglycemia-induced vascular inflammation by increasing GSK3β-Ser9 phosphorylation in endothelial cells and mouse aortas.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Song KH,Bae SJ,Chang J,Park JH,Jo I,Cho KW,Cho DH

    更新日期:2017-09-30 00:00:00

  • Heart rhythm genomic fabric in hypoxia.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Iacobas DA,Iacobas S,Haddad GG

    更新日期:2010-01-22 00:00:00

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ozawa F,Friess H,Zimmermann A,Kleeff J,Büchler MW

    更新日期:2000-05-10 00:00:00

  • A fluorescence-based rapid screening assay for cytotoxic compounds.

    abstract::A simple fluorescence-based assay was developed for the rapid screening of potential cytotoxic compounds generated by combinatorial chemistry. The assay is based on detection of nuclear green fluorescent protein (GFP) staining of a human cervical cancer cell line (HeLa) carrying an integrated histone H2B-GFP fusion ge...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Montoya J,Varela-Ramirez A,Estrada A,Martinez LE,Garza K,Aguilera RJ

    更新日期:2004-12-24 00:00:00

  • Study of multi-drug resistant mechanisms in a taxol-resistant hepatocellular carcinoma QGY-TR 50 cell line.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Zhou J,Cheng SC,Luo D,Xie Y

    更新日期:2001-02-09 00:00:00