Effect of neurturin on multipotent cells isolated from the adult skeletal muscle.

Abstract:

:Ligands of the glial cell line-derived neurotrophic factors (GDNF)-family are trophic factors for the development and survival of multiple cell types, however their effects on non-neuronal stem cells are unknown. We examined the action of neurturin on a candidate stem cell population isolated from adult skeletal muscles. When grown as spheres, these cells expressed mRNAs for GDNF, persephin, GFR-alpha2, GFR-alpha4 (neurturin receptor), and Ret. Exposure of these cells to neurturin significantly augmented cell numbers via increased cell proliferation. After addition of retinoic acid, the cells exited the cell cycle, developed thin processes, and became immunoreactive for betaIII-tubulin, while Ret mRNA expression decreased, without changes in the level of GFR-alpha2 mRNA. Neurturin induced an outgrowth of processes on these betaIII-tubulin positive cells. Neurturin may therefore be beneficial in the use of these multipotent cells isolated from adult muscles for autologous transplants in neurological applications.

authors

Vourc'h P,Lacar B,Mignon L,Lucas PA,Young HE,Chesselet MF

doi

10.1016/j.bbrc.2005.04.104

subject

Has Abstract

pub_date

2005-06-24 00:00:00

pages

215-23

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)00794-1

journal_volume

332

pub_type

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