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Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells.

Abstract：

:Prolactin, the Janus kinase 2 (JAK2) and the signal transducer and activator of transcription 5 (STAT5) are important for mammary gland development and have also been implicated in development and growth of breast tumors. In the present study we have investigated the role for JAK2 in proliferation, differentiation, and apoptosis of the mammary epithelial cell line HC11 by stably overexpressing two hyperactive JAK2 mutants. Cells expressing a JAK2 mutant consisting of only the kinase domain had high amount of nuclear STAT5 protein with low DNA-binding activity, which was rapidly induced to a DNA-binding state by prolactin treatment. Cells expressing JAK2 deleted of the kinase-like domain showed increased sensitivity to prolactin treatment compared to wild type cells. Proliferation was not affected by any of the mutants whereas the ability to undergo apoptosis was decreased implicating a transforming potential of the JAK2 mutants.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Olsen H,Hedengran Faulds MA,Saharinen P,Silvennoinen O,Haldosén LA

doi

10.1016/s0006-291x(02)00847-1

subject

Has Abstract

pub_date

2002-08-09 00:00:00

pages

139-44

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006291X02008471

journal_volume

296

pub_type

杂志文章

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