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Inhibition of the proteolysis of rat erythrocyte membrane proteins by a synthetic inhibitor of calpain.

Abstract：

:A synthetic inhibitor of calpain protects rat erythrocyte membrane-associated cytoskeletal proteins from proteolytic degradation (IC50 = 1 microM) which occurs when the cells are rendered permeable to Ca++. Leupeptin, a naturally occurring inhibitor of the enzyme, does not afford any protection at concentrations up to 100 microM.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Mehdi S,Angelastro MR,Wiseman JS,Bey P

doi

10.1016/s0006-291x(88)80989-6

subject

Has Abstract

pub_date

1988-12-30 00:00:00

pages

1117-23

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)80989-6

journal_volume

157

pub_type

杂志文章

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