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Isolation of wound healing/regeneration genes using restrictive fragment differential display-PCR in MRL/MPJ and C57BL/6 mice.

Abstract：

:Wound healing in mammals can take several weeks to months and the process is always accompanied by scar formation. Wound healing mechanisms that mimic regeneration are not found in most mature mammalian tissues. However, the MRL/MPJ (MRL) mouse has the unique capacity to regenerate ear hole wound completely in less than a month. To identify genes involved in wound healing without a scar, we chose to use restriction fragment differential display-PCR to isolate genes differentially expressed in the MRL (good healer) mouse and the C57BL/6 (poor healer) mouse at different stages of wound healing. We identified 36 genes that were differentially expressed in the regenerating tissue of good and poor healer strains of which several genes are also genetically linked to wound healing and thus are potential candidate genes for scarless wound healing.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Masinde G,Li X,Baylink DJ,Nguyen B,Mohan S

doi

10.1016/j.bbrc.2005.02.143

subject

Has Abstract

pub_date

2005-04-29 00:00:00

pages

117-22

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)00404-3

journal_volume

330

pub_type

杂志文章

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