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Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level.

Abstract：

:PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase that promotes aerobic glycolysis. Here, we describe an important role for PKM2 in regulating the survival of gastric cancer (GC) cells. We showed that PKM2 was overexpressed in gastric tumor tissues compared to normal tissues and its expression level was associated with poor survival of gastric cancer patients. We also showed that PKM2 affected cell survival by regulating Bcl-xL at the transcriptional level. PKM2 knockdown partially affected the stability of NF-kB subunit p65, suggesting that post-translational regulation of p65 by PKM2 is one of plausible mechanisms for the increased cell growth. Therefore, PKM2 may function as an upstream molecule that regulates p65 function and thus enhances the growth of tumor cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kwon OH,Kang TW,Kim JH,Kim M,Noh SM,Song KS,Yoo HS,Kim WH,Xie Z,Pocalyko D,Kim SY,Kim YS

doi

10.1016/j.bbrc.2012.05.063

subject

Has Abstract

pub_date

2012-06-22 00:00:00

pages

38-44

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(12)00940-0

journal_volume

423

pub_type

杂志文章

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