Molecular interplays involved in the cellular uptake of octaarginine on cell surfaces and the importance of syndecan-4 cytoplasmic V domain for the activation of protein kinase Cα.

abstract：:Vascular endothelial growth factor (VEGF) is one of the major angiogenesis regulators. It binds to its tyrosine kinase receptors, KDR and Flt-1. However, little is known about their downstream signal transduction properties. We screened human brain cDNA library using the yeast two-hybrid system with the KDR cytoplasmi...

journal_title：Biochemical and biophysical research communications

authors： Igarashi K,Shigeta K,Isohara T,Yamano T,Uno I

更新日期：1998-10-09 00:00:00

abstract：:The gene encoding sericin 1 (Ser1) of silkworm (Bombyx mori) is specifically expressed in the middle silk gland cells. To identify element involved in this transcription-dependent spatial restriction, truncation of the 5' terminal from the sericin 1 (Ser1) promoter is studied in vivo. A 209bp DNA sequence upstream of ...

journal_title：Biochemical and biophysical research communications

authors： Liu Y,Yu L,Guo X,Guo T,Wang S,Lu C

更新日期：2006-03-31 00:00:00

abstract：:Elevations in intracellular Ca(2+) ([Ca(2+)](i)) initiate insulin secretion from pancreatic beta-cells, but the secretory responses become rapidly desensitised to maintained elevations in [Ca(2+)](i). We have investigated the mechanisms underlying the Ca(2+) desensitization of insulin secretion using electrically perm...

journal_title：Biochemical and biophysical research communications

authors： Harris TE,Persaud SJ,Squires PE,Jones PM

更新日期：2000-04-21 00:00:00

abstract：:Gallbladder carcinoma (GBC), an aggressive and mostly lethal malignancy, is known to be resistant to a number of drug stimuli. Here, we demonstrated that arsenic trioxide inhibited the proliferation of gallbladder carcinoma in vivo and in vitro as well as the transcription of cell cycle-related protein Cyclin D1. And,...

journal_title：Biochemical and biophysical research communications

authors： Ai Z,Lu W,Ton S,Liu H,Sou T,Shen Z,Qin X

更新日期：2007-08-31 00:00:00

abstract：:The RNA-dependent RNA polymerase (RdRP) of the Hepatitis C virus (HCV), named NS5B, is phosphorylated by the cellular protein kinase C-related kinase 2 (PRK2) at two serine residues (Ser29 and Ser42) of the finger subdomain (genotype 1b). Herein, using bioinformatics, we selected four potential phosphorylation residue...

journal_title：Biochemical and biophysical research communications

authors： Hernández S,Figueroa D,Correa S,Díaz A,Aguayo D,Villanueva RA

更新日期：2015-10-09 00:00:00

abstract：:Chemiluminescence in visible region was detected, during peroxidase-catalyzed oxidation of chlorpromazine at pH7.5 (but not at pH4.25) or of propericiazine, both at pH7.5 and at pH4.25. Red colored intermediates, cation radicals, were produced and decayed in all enzymatic systems used. Chemiluminescence was also detec...

journal_title：Biochemical and biophysical research communications

authors： Nakano M,Sugioka K,Nakano H,Takyu C,Inaba H

更新日期：1985-08-15 00:00:00

abstract：:SpYPT1p belongs to a family of ras-like GTP-binding proteins which is believed to be involved in the regulation of intracellular vesicular trafficking. We have analyzed the processing of this protein in its natural environment, the fission yeast Schizosaccharomyces pombe, and when expressed in transfected mammalian CO...

journal_title：Biochemical and biophysical research communications

authors： Giannakouros T,Newman CM,Armstrong J,Magee AI

更新日期：1993-05-14 00:00:00

abstract：:We found a novel protein-protein interaction between ubiquitin-specific protease 15 (USP15) and skeletal muscle LIM protein 1 (SLIM1): USP15 and SLIM1 directly bound under cell-free conditions and co-immunoprecipitated from the lysates of the cells, where they were co-expressed; and USP15 deubiquitinated SLIM1, result...

journal_title：Biochemical and biophysical research communications

authors： Isumi Y,Hirata T,Saitoh H,Miyakawa T,Murakami K,Kudoh G,Doi H,Ishibashi K,Nakajima H

更新日期：2011-02-11 00:00:00

abstract：:Plant heat shock transcription factors (HSF) are highly complex. In this study, we identified an alfalfa HSF gene MsHSF1 that is composed of four exons and three introns in the encoding region. The intron1-exon2-intron2-exon3-intron3 as an intervening sequence was inserted at the conserved position that separates the ...

journal_title：Biochemical and biophysical research communications

authors： He ZS,Xie R,Zou HS,Wang YZ,Zhu JB,Yu GQ

更新日期：2007-12-28 00:00:00

abstract：:We have used human neuroblastoma NB-OK1 cells to investigate the regulation of neurite outgrowth. Carbachol suppressed forskolin-stimulated neurite outgrowth in NB-OK1 cells although forskolin-stimulated cAMP levels were enhanced. The dose-response curve for this suppression was very similar to that for stimulation of...

journal_title：Biochemical and biophysical research communications

authors： Nakagawa-Yagi Y,Saito Y,Takada Y,Nakamura H

更新日期：1992-01-15 00:00:00

abstract：:Transgenic animals were used to examine the spatial and temporal regulation of the human beta amyloid precursor protein (APP) gene promoter region in vivo. A 2.9 kb DNA fragment encompassing the APP gene promoter was fused to the chloramphenical acetyltransferase (CAT) reporter gene (pAMY-CAT) or a partial cDNA encodi...

journal_title：Biochemical and biophysical research communications

authors： Fox NW,Johnstone EM,Ward KE,Schrementi J,Little SP

更新日期：1997-11-26 00:00:00

abstract：:Linkage-specific polyubiquitination regulates many cellular processes. The N-terminal fragment of Rabex-5 (Rabex-5(9-73)) contains tandem ubiquitin binding domains: A20_ZF and MIU. The A20_ZF-MIU of Rabex-5 is known to bind monoubiquitin but molecular details of polyubiquitin binding affinity and linkage selectivity b...

journal_title：Biochemical and biophysical research communications

authors： Shin D,Lee SY,Han S,Ren S,Kim S,Aikawa Y,Lee S

更新日期：2012-07-13 00:00:00

abstract：:It has been shown that MDM2 inhibits the transcriptional and pro-apoptotic activities of p73 but does not promote its proteasomal degradation. In this study, we found that MDM2 indirectly induces the degradation of p73 through the interaction with Itch in HeLa cells. During adriamycin (ADR)-mediated apoptosis, p53 and...

journal_title：Biochemical and biophysical research communications

authors： Kubo N,Okoshi R,Nakashima K,Shimozato O,Nakagawara A,Ozaki T

更新日期：2010-12-17 00:00:00

abstract：:Expression of TNF-alpha gene in the retinal pigment epithelial (RPE) cells was studied by using polymerase chain reaction (PCR). PCR for human TNF-alpha gene using complementary DNA (cDNA) of control RNA prepared from non-stimulated RPE cells failed to show expression of TNF-alpha gene. However, PCR by using cDNA prep...

journal_title：Biochemical and biophysical research communications

authors： Tanihara H,Yoshida M,Yoshimura N

更新日期：1992-09-16 00:00:00

abstract：:A critical aspect of sexual development in Dictyostelium is the selection of "self" as a targeted food source by the phagocytic zygotic giant cell (ZGC). It has previously been demonstrated that phagocytic giant cells preferentially take up amoebae of the same species suggesting that the process is mediated by a speci...

journal_title：Biochemical and biophysical research communications

authors： Lewis KE,Jamieson JC

更新日期：1997-01-23 00:00:00

abstract：:Although transformed androgen receptor (AR) complexes derived from cytosol and nuclear AR complexes have been shown to bind with high affinity to nuclei and DNA, we have shown that the binding characteristics of the two receptor populations to rat ventral prostate nuclei are different. To account for these differences...

journal_title：Biochemical and biophysical research communications

authors： Golsteyn EJ,Goren HJ,Lehoux JG,Lefebvre YA

更新日期：1990-08-31 00:00:00

abstract：:We discovered recently that Parkinsonism-associated DJ-1 and its bacterial homologs function as protein deglycases that repair glyoxal- and methylglyoxal-glycated proteins. Protein glycation levels are 2- to 10-fold increased in deglycase-depleted cells, and deglycase mutants display up to 500-fold loss of viability i...

journal_title：Biochemical and biophysical research communications

authors： Richarme G,Dairou J

更新日期：2017-01-29 00:00:00

abstract：:The omega-3 fatty acid eicosapentaenoic acid (EPA) reduces oxidation of ApoB-containing particles in vitro and in patients with hypertriglyceridemia. EPA may produce these effects through a potent antioxidant mechanism, which may facilitate LDL clearance and slow plaque progression. We hypothesize that EPA antioxidant...

journal_title：Biochemical and biophysical research communications

authors： Sherratt SCR,Mason RP

更新日期：2018-02-05 00:00:00

abstract：:CARMA3 was recently reported to be overexpressed in cancers and associated with the malignant behavior of cancer cells. However, the expression of CARMA3 and its biological roles in colon cancer have not been reported. In the present study, we analyzed the expression pattern of CARMA3 in colon cancer tissues and found...

journal_title：Biochemical and biophysical research communications

authors： Miao Z,Zhao T,Wang Z,Xu Y,Song Y,Wu J,Xu H

更新日期：2012-09-07 00:00:00

abstract：:The effect of glucocorticoid hormones on the protein responsible for both nucleotide pyrophosphatase (EC 3.6.1.9) and alkaline phosphodiesterase I (EC 3.1.4.1) activities was examined in murine MOPC 315 plasmacytoma cells. Incubation of these cells with dexamethasone resulted in parallel increases in pyrophosphatase a...

journal_title：Biochemical and biophysical research communications

authors： Rebbe NF,Hickman S

更新日期：1991-03-15 00:00:00

abstract：:It remains controversial whether deficiency of the Niemann-Pick C1 (npc1) protein results in altered cholesterol signaling at the endoplasmic reticulum (ER). In this report, we have measured the processed, nuclear form of sterol regulatory element binding protein (SREBP)-1 in livers of npc1 wild-type, heterozygous, an...

journal_title：Biochemical and biophysical research communications

authors： Erickson RP,Kiela M,Garver WS,Krishnan K,Heidenreich RA

更新日期：2001-06-08 00:00:00

abstract：:Bone morphogenetic protein7 (BMP7) attenuates renal tubular and interstitial damage in a variety of experimental models. The function of BMP in the glomerulus is, however, not well understood. In the present study, we generated transgenic mice carrying cDNA for noggin, an endogenous inhibitor of BMPs, driven by the po...

journal_title：Biochemical and biophysical research communications

authors： Miyazaki Y,Ueda H,Yokoo T,Utsunomiya Y,Kawamura T,Matsusaka T,Ichikawa I,Hosoya T

更新日期：2006-02-10 00:00:00

abstract：:A 2.1-kb genomic region responsible for Ogawa serotype specificity of Vibrio cholerae 01 was identified by cosmid cloning and recombinant plasmid experiments. The plasmid carrying this region derived from Ogawa type Vibrio cholerae NIH 41 coded for a specific protein of 27 kD, and was found to convert serotype specifi...

journal_title：Biochemical and biophysical research communications

authors： Ito T,Ohshita Y,Nakamoto T,Hiramatsu K,Yokota T

更新日期：1991-03-15 00:00:00

abstract：:Guanylin and uroguanylin are structurally related intestinal peptide hormones which were purified from a limited number of mammals and are capable of activating the particulate guanylate cyclase-C. Although the biological functions of guanylin and uroguanylin are not yet clarified in detail, they are involved in the r...

journal_title：Biochemical and biophysical research communications

authors： Mägert HJ,Hill O,Zucht HD,Martin S,Meyer M,Forssmann WG,Adermann K

更新日期：1999-05-27 00:00:00

abstract：:Measurements of the cytosolic calcium concentration in single cells of the clonal endocrine pancreatic glucagon-secreting cell line INR1 G9 revealed the existence of spontaneous calcium oscillations in 20-70% of these cells. Inhibition of these spontaneous oscillations by thapsigargin as well as the phospholipase C in...

journal_title：Biochemical and biophysical research communications

authors： Bode HP,Yule DI,Fehmann HC,Göke B,Williams JA

更新日期：1994-11-30 00:00:00

abstract：:Two species of scarab beetles, the Osaka beetle (Anomala osakana) and the Japanese beetle (Popillia japonica), utilize the opposite enantiomers of japonilure, (Z)-5-(1-decenyl)oxacyclopentan-2-one, as their sex pheromones. Each species produces only one of the enantiomers that functions as its own sex pheromone and as...

journal_title：Biochemical and biophysical research communications

authors： Wojtasek H,Hansson BS,Leal WS

更新日期：1998-09-18 00:00:00

abstract：:The patch clamp technique applied to canine atrial myocyte sarcolemma, showed that 2 types of K+ channels were differentially affected by Ach. The 2 channel types differed in conductance, responses to [Ca++], and sensitivity to membrane potential. Addition of Ach (10(-9) M to 10(-6) M) to pipette solutions increased o...

journal_title：Biochemical and biophysical research communications

authors： Bubien JK,Woods WT Jr

更新日期：1987-02-13 00:00:00

abstract：:The present study aimed to establish a novel efficient nonviral strategy for suicide gene transfer in hepatocellular carcinoma (HCC) in vivo. We employed branched polyethylenimine (PEI) and combined it with Epstein-Barr virus (EBV)-based plasmid vectors. The HCC cells transfected with an EBV-based plasmid carrying the...

journal_title：Biochemical and biophysical research communications

authors： Iwai M,Harada Y,Tanaka S,Muramatsu A,Mori T,Kashima K,Imanishi J,Mazda O

更新日期：2002-02-15 00:00:00

abstract：:Human erythrocytes express a p57 membrane serine proteinase which cleaves C3, the third component of complement. Amino acid analysis of the first 20 N-terminal residues of the purified p57 proteinase demonstrated 100% homology with residues 910-929 of erythrocyte ankyrin, a sequence localized in its Mr = 62 kDa fragme...

journal_title：Biochemical and biophysical research communications

authors： Hermann J,Barel M,Frade R

更新日期：1994-10-28 00:00:00

abstract：:To study how different domains of the muscle-specific intermediate filament protein, desmin, contribute to its polymerization, two of its CNBr fragments were examined as to their oligomeric structure under assembly conditions. One of these, D88, covers residues 1-88 and represents almost the entire headpiece; the othe...

journal_title：Biochemical and biophysical research communications

authors： Saeed T,Ip W

更新日期：1989-12-29 00:00:00