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Attracted or repelled?--a matter of two neurons, one pheromone binding protein, and a chiral center.

Abstract：

:Two species of scarab beetles, the Osaka beetle (Anomala osakana) and the Japanese beetle (Popillia japonica), utilize the opposite enantiomers of japonilure, (Z)-5-(1-decenyl)oxacyclopentan-2-one, as their sex pheromones. Each species produces only one of the enantiomers that functions as its own sex pheromone and as a very strong behavioral antagonist for the other species. Using an integrated approach we tested whether the discrimination of these two opposite signals is due to selective filtering by pheromone binding proteins or whether it originates in the specificity of ligand-receptor interactions. We found that the antennae of each of these two scarab species contain only a single pheromone binding protein, which associates with both enantiomers to a similar extent. The single neuron recording technique, on the other hand, showed that both species possess olfactory receptor neurons, colocalized in one sensillum, extremely specific to either (R)- or (S)-japonilure. Therefore, pheromone binding proteins (PBPs) alone cannot perform the task of chiral discrimination; enantiomeric specificity must be achieved by the interaction of the pheromone or the appropriate ligand-PBP complex with membrane receptors.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wojtasek H,Hansson BS,Leal WS

doi

10.1006/bbrc.1998.9278

subject

Has Abstract

pub_date

1998-09-18 00:00:00

pages

217-22

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(98)99278-6

journal_volume

250

pub_type

杂志文章

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