Isoform-specific phosphorylation of fission yeast type 2C protein phosphatase.

abstract：:Xanthine oxidase (XO) was found to convert nitric oxide (NO* ) released from spermine-NONOate to nitroxyl (HNO), the one-electron reduction product of NO*, in the presence of its substrate hypoxanthine under anaerobic conditions. Under these conditions, XO lost its activity. Upon aerobic incubation of XO with its subs...

journal_title：Biochemical and biophysical research communications

authors： Saleem M,Ohshima H

更新日期：2004-03-05 00:00:00

abstract：:We presently investigated the effects of pyrrolidine dithiocarbamate (PDTC), a potent inhibitor of nuclear factor kappa B (NF-kappa B), on the induction of nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) mRNAs by IL-1 beta in insulin-producing RIN cells. PDTC decreased by 90% both IL-1 beta-ind...

journal_title：Biochemical and biophysical research communications

authors： Bedoya FJ,Flodström M,Eizirik DL

更新日期：1995-05-25 00:00:00

abstract：:Circulating human mononuclear blood cells were studied for the presence of specific 1,25-dihydroxyvitamin D3 (calcitriol) binding macromolecules. Cells were isolated by density gradient centrifugation and characterized by surface markers. Specific reversible high affinity binding by a 3.5 S macromolecule was demonstra...

journal_title：Biochemical and biophysical research communications

authors： Merke J,Senst S,Ritz E

更新日期：1984-04-16 00:00:00

abstract：:Lactobacillus, a representative useful bacterium, in the intestinal tract was found to bind to some specific glycosphingolipids, like the pathogenic intestinal bacteria. Thin layer chromatography overlay assays using rabbit antiserum against Lactobacillus casei revealed that the bacteria bound to GA1 and trihexosylcer...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto K,Miwa T,Taniguchi H,Nagano T,Shimamura K,Tanaka T,Kumagai H

更新日期：1996-11-01 00:00:00

abstract：:Examination of human follicular fluid revealed the presence of polychlorinated dibenzodioxins (PCDDs) and dibenzofurans (PCDFs) at concentrations of approximately 1 pg/ml (0.01 pg TEQ/ml). To study their possible action, two-cell mouse embryos were cultured in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)...

journal_title：Biochemical and biophysical research communications

authors： Tsutsumi O,Uechi H,Sone H,Yonemoto J,Takai Y,Momoeda M,Tohyama C,Hashimoto S,Morita M,Taketani Y

更新日期：1998-09-18 00:00:00

abstract：:The somatostatin analogue, TT-232 inhibits cell proliferation and induces apoptosis in a variety of tumor cells both in vivo and in vitro. While the early transient activation of Erk/MAPK was found to be important for the induction of cell cycle arrest, the signaling pathway leading to the activation of Erk/MAPK had n...

journal_title：Biochemical and biophysical research communications

authors： Steták A,Csermely P,Ullrich A,Kéri G

更新日期：2001-11-02 00:00:00

abstract：:Complementary DNA corresponding to total poly(A)+-RNA from the human A431 epidermoid carcinoma cell line was cloned in the phage expression vector lambda gt 11. An epidermal growth factor (EGF) receptor cDNA clone was obtained by screening of the expression library with a rabbit polyclonal antibody (IgG), raised to th...

journal_title：Biochemical and biophysical research communications

authors： Simmen FA,Gope ML,Schulz TZ,Wright DA,Carpenter G,O'Malley BW

更新日期：1984-10-15 00:00:00

abstract：:The Drosophila Toll-1 receptor is involved in embryonic development, innate immunity, and tissue homeostasis. Currently, as a ligand for the Toll-1 receptor, only Spätzle (Spz) has been identified and characterized. We previously reported that Drosophila larva-derived tissue extract contains ligand activity for the To...

journal_title：Biochemical and biophysical research communications

authors： Nonaka S,Kawamura K,Hori A,Salim E,Fukushima K,Nakanishi Y,Kuraishi T

更新日期：2018-11-30 00:00:00

abstract：:This is the first study to demonstrate that the AT motif binding factor 1-A (ATBF1-A) is expressed in the crypts and the bases of villi of the small intestine and negatively regulates transcription of brush-border enzyme gene, aminopeptidase-N (APN). In situ hybridization visualized a limited ATBF1-A mRNA expression i...

journal_title：Biochemical and biophysical research communications

authors： Kataoka H,Joh T,Miura Y,Tamaoki T,Senoo K,Ohara H,Nomura T,Tada T,Asai K,Kato T,Itoh M

更新日期：2000-01-07 00:00:00

abstract：:The steady state kinetic study and some enzymic characterization of a selenium-containing scFv catalytic antibody (Se-scFv2F3) was carried out. A novel reaction formula of this abzyme-catalyzed reaction was proposed and a rate equation was gotten according to the formula. The constants in the equation were compared wi...

journal_title：Biochemical and biophysical research communications

authors： Su D,You D,Ren X,Luo G,Mu Y,Yan G,Xue Y,Shen J

更新日期：2001-07-20 00:00:00

abstract：:The tumor suppressor p53, a 393-amino acid transcription factor with four domains, induces cell cycle arrest, senescence, and apoptosis in response to diverse stress. Tetramer formation is critical for the function of p53. The tetramerization domain permits the tetramerization of p53, where bundled four DNA-binding do...

journal_title：Biochemical and biophysical research communications

authors： Inobe T,Nozaki M,Nukina N

更新日期：2015-11-13 00:00:00

abstract：:Dimerization of epidermal growth factor receptor (EGFR) leads to the activation of its tyrosine kinase. To elucidate whether dimerization is responsible for activation of the intracellular tyrosine kinase domain or just plays a role in the stabilization of the active form, the activated status of wild-type EGFR moiety...

journal_title：Biochemical and biophysical research communications

authors： Ge G,Wu J,Wang Y,Lin Q

更新日期：2002-01-25 00:00:00

abstract：:Insulin and glucagon secretion from the islets of Langerhans is highly regulated. Although an increased plasma glucose level is the major stimulus for insulin exocytosis, roles for glutamine and glutamate have been suggested. Interestingly, the islet cells display elements associated with synaptic transmission. In the...

journal_title：Biochemical and biophysical research communications

authors： Gammelsaeter R,Jenstad M,Bredahl MK,Gundersen V,Chaudhry FA

更新日期：2009-04-10 00:00:00

abstract：:Highly purified bovine heart protein phosphatase 2A catalytic subunit lost virtually all of its activity during storage at -70 degrees. When the enzyme was preincubated with Co2+, over 35% of the original activity was restored. Freshly prepared protein phosphatase 2A purified from bovine heart was stimulated at least ...

journal_title：Biochemical and biophysical research communications

authors： Cai L,Chu Y,Wilson SE,Schlender KK

更新日期：1995-03-08 00:00:00

abstract：:Although it has been shown that calpains may play a positive role in causing apoptosis of T cells, we report here that, on the contrary, the inhibition of calpain-like activities can induce apoptosis in human prostate cancer cells. Two calpain inhibitors were used to test growth response on prostate cancer cells and s...

journal_title：Biochemical and biophysical research communications

authors： Zhu W,Murtha PE,Young CY

更新日期：1995-09-25 00:00:00

abstract：:We have investigated the effects of three unrelated topoisomerase 2 inhibitors, genistein, adriamycin, and etoposide, on phosphorylation/activation of the checkpoint kinase Chk2 in normal or ATM-deficient (ATM-) human fibroblasts and in cells overexpressing a catalytically inactive ATR kinase. We demonstrate that geni...

journal_title：Biochemical and biophysical research communications

authors： Théard D,Coisy M,Ducommun B,Concannon P,Darbon JM

更新日期：2001-12-21 00:00:00

abstract：:A cDNA for a GnRH receptor (mtGnRH-R) was obtained from a mouse gonadotropic pituitary cell line (alpha T3-1) by expression cloning. This full-length cDNA was subsequently used as a probe to clone a rat pituitary GnRH receptor (rGnRH-R). The two receptors differ by 13 amino acids and are 100% identical to those recent...

journal_title：Biochemical and biophysical research communications

authors： Perrin MH,Bilezikjian LM,Hoeger C,Donaldson CJ,Rivier J,Haas Y,Vale WW

更新日期：1993-03-31 00:00:00

abstract：:Several recent studies have suggested that cancer stem cells (CSCs) are involved in resistance to gefitinib in non-small cell lung cancer (NSCLC). Oct4, a member of the POU-domain transcription factor family, has been shown to be involved in CSC properties of various cancers. We previously reported that Oct4 and the p...

journal_title：Biochemical and biophysical research communications

authors： Kobayashi I,Takahashi F,Nurwidya F,Nara T,Hashimoto M,Murakami A,Yagishita S,Tajima K,Hidayat M,Shimada N,Suina K,Yoshioka Y,Sasaki S,Moriyama M,Moriyama H,Takahashi K

更新日期：2016-04-22 00:00:00

abstract：:Vibrio cholerae cytolysin (VCC), a β-barrel pore-forming toxin (β-PFT), induces killing of the target eukaryotic cells by forming heptameric transmembrane β-barrel pores. Consistent with the β-PFT mode of action, binding of the VCC toxin monomers with the target cell membrane triggers formation of pre-pore oligomeric ...

journal_title：Biochemical and biophysical research communications

authors： Paul K,Chattopadhyay K

更新日期：2014-01-03 00:00:00

abstract：:Rat neuromedin U was isolated from the small intestine using mainly immunoaffinity chromatography and radioimmunoassay for pig neuromedin U-8. The amino acid sequence of rat neuromedin U was determined by microsequence analysis to be Tyr-Lys-Val-Asn-Glu-Tyr-Gln-Gly-Pro-Val-Ala-Pro-Ser-Gly-Gly- Phe-Phe-Leu-Phe-Arg-Pro-...

journal_title：Biochemical and biophysical research communications

authors： Minamino N,Kangawa K,Honzawa M,Matsuo H

更新日期：1988-10-14 00:00:00

abstract：:The RNase gene superfamily combines functionally divergent proteins which share statistically significant sequence similarity. Known members assigned to this family include secretory and nonsecretory RNases; angiogenin; eosinophil cationic protein; eosinophil-derived neurotoxin; sialic-acid binding lectin and anti-tum...

journal_title：Biochemical and biophysical research communications

authors： Klenova EM,Botezato I,Laudet V,Goodwin GH,Wallace JC,Lobanenkov VV

更新日期：1992-05-29 00:00:00

abstract：:Germ-line alterations in BRCA1 are associated with an increased susceptibility to breast and ovarian cancer. The BRCA1 protein has been implicated in multiple cellular functions. We have recently demonstrated that BRCA1 reduces acetyl-CoA-carboxylase alpha (ACCA) activity through its phospho-dependent binding to ACCA,...

journal_title：Biochemical and biophysical research communications

authors： Ray H,Suau F,Vincent A,Dalla Venezia N

更新日期：2009-01-16 00:00:00

abstract：:A biotin-polyethylene glycol (PEG)-epidermal growth factor (EGF) conjugate was immobilized onto the surface of avidin-modified adenovirus (ADV-Avi) via biotin-avidin interaction to deliver ADV specifically to EGF receptor over-expressing cancer cells. ADV-Avi/biotin-PEG-EGF complexes showed greatly enhanced intracellu...

journal_title：Biochemical and biophysical research communications

authors： Park JW,Mok H,Park TG

更新日期：2008-02-15 00:00:00

abstract：:In this work, we show that glucose-induced activation of plasma membrane H(+)-ATPase from Saccharomyces cerevisiae is strongly dependent on calcium metabolism and that the glucose sensor Snf3p works in a parallel way with the G protein Gpa2p in the control of the pathway. The role of Snf3p is played by the Snf3p C-ter...

journal_title：Biochemical and biophysical research communications

authors： Trópia MJ,Cardoso AS,Tisi R,Fietto LG,Fietto JL,Martegani E,Castro IM,Brandão RL

更新日期：2006-05-19 00:00:00

abstract：:Focal adhesion kinase (FAK) and integrin-linked kinase (ILK) are both involved in integrin-mediated cell migration. However, the molecular mechanism, and the relationship between FAK and ILK activity in signaling transduction for the osteopontin (OPN)-induced migration of vascular smooth muscle cells (VSMCs) remain un...

journal_title：Biochemical and biophysical research communications

authors： Li JJ,Han M,Wen JK,Li AY

更新日期：2007-04-27 00:00:00

abstract：:Mutations in mitochondrial DNA is one of the important causes of hearing loss. Here, we performed a mutational screening of tRNA(Ser(UCN)) gene in 1542 Chinese subjects with hearing loss. One subject and five subjects carried tRNA(Ser(UCN)) A7445C and G7444A mutations, respectively, while two subjects harbored both G7...

journal_title：Biochemical and biophysical research communications

authors： Jin L,Yang A,Zhu Y,Zhao J,Wang X,Yang L,Sun D,Tao Z,Tsushima A,Wu G,Xu L,Chen C,Yi B,Cai J,Tang X,Wang J,Li D,Yuan Q,Liao Z,Chen J,Li Z,Lu J,Guan MX

更新日期：2007-09-14 00:00:00

abstract：:The human pancreas carcinoma cell line T3M-4 contains activated c-Kirsten (K)-ras oncogene detectable by the DNA-mediated gene transfer technique using NIH/3T3 cells. DNA fragments containing coding lesions have been cloned, and nucleotide sequence analysis suggests that the T3M-4 oncogene has been activated by a sing...

journal_title：Biochemical and biophysical research communications

authors： Hirai H,Okabe T,Anraku Y,Fujisawa M,Urabe A,Takaku F

更新日期：1985-02-28 00:00:00

abstract：:Angiogenesis is a core hallmark of advanced cancers, especially in lung adenocarcinoma (LUAD). However, the underlying functions and mechanisms of lncRNAs in tumor angiogenesis remain largely unknown. Here we found that linc00665 depletion could markedly depressed proliferation and capillary tube formation of HUVECs i...

journal_title：Biochemical and biophysical research communications

authors： Cong Z,Diao Y,Li X,Jiang Z,Xu Y,Zhou H,Qiang Y,Wu H,Shen Y

更新日期：2020-06-25 00:00:00

abstract：:The DiFi and HT-29 human colorectal cancer cell lines were characterized and compared with respect to binding properties of alpha adrenoceptors present on the cell surface. Both cell lines possessed alpha-1 and alpha-2 adrenoceptors of high affinity; however, DiFi cells were rich in alpha-1 adrenoceptors, whereas HT-2...

journal_title：Biochemical and biophysical research communications

authors： Agrawal DK,Wildrick DM,Boman BM

更新日期：1992-05-29 00:00:00

abstract：:Several RNAs, including rRNAs, snRNAs, snoRNAs, and some mRNAs, are known to be localized at specific sites in a cell. Although methods have been established to visualize RNAs in a living cell, no large-scale visual screening of localized RNAs has been performed. In this study, we constructed a genomic library in whic...

journal_title：Biochemical and biophysical research communications

authors： Andoh T,Oshiro Y,Hayashi S,Takeo H,Tani T

更新日期：2006-12-29 00:00:00