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Isolation and structural determination of rat neuromedin U.

Abstract：

:Rat neuromedin U was isolated from the small intestine using mainly immunoaffinity chromatography and radioimmunoassay for pig neuromedin U-8. The amino acid sequence of rat neuromedin U was determined by microsequence analysis to be Tyr-Lys-Val-Asn-Glu-Tyr-Gln-Gly-Pro-Val-Ala-Pro-Ser-Gly-Gly- Phe-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2, and this structure was confirmed by synthesis. Although the C-terminal heptapeptide amide structure of pig neuromedin U is completely conserved in rat neuromedin U, the remainder of the peptide reveals nine amino acid replacements and two amino acid deletions when compared to pig neuromedin U-25. Rat neuromedin U exerts two-fold potent uterus stimulant activity as compared to pig neuromedin U-25.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Minamino N,Kangawa K,Honzawa M,Matsuo H

doi

10.1016/s0006-291x(88)80848-9

subject

Has Abstract

pub_date

1988-10-14 00:00:00

pages

355-60

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)80848-9

journal_volume

156

pub_type

杂志文章

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