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The immunoglobulin-like domain is involved in interaction of Neuregulin1 with ErbB.

Abstract：

:Neuregulin1 (NRG1) is a growth factor that signals through the interaction of the epidermal growth factor (EGF)-like domain with ErbB receptors. An immunoglobulin (Ig)-like domain is contained together with EGF-like domain in the ectodomain of some isoforms generated by alternative splicing, but its role in NRG1 signaling remained unclear. In the present study, we identified a novel isoform of NRG1 containing an Ig-like domain conserved among species from adult Xenopus laevis, which is predominantly expressed in the testis and brain. We generated recombinant proteins for the whole ectodomain and EGF-like domain alone of the isoform to compare their effects on cell proliferation, and phosphorylation of and their association with ErbB receptor, demonstrating that the ectodomain had approximately 10(3)-fold higher abilities than the EGF-like domain. Therefore, the Ig-like domain is probably essential for efficient interaction of an EGF-like domain with ErbB receptors.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Eto K,Eda K,Kanemoto S,Abe S

doi

10.1016/j.bbrc.2006.09.028

subject

Has Abstract

pub_date

2006-11-17 00:00:00

pages

263-71

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)02050-X

journal_volume

350

pub_type

杂志文章

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