Tauroursodeoxycholic acid improves viability of artificial RBCs.

abstract：:Dihydroflavin mononucleotide (FMNH2) and tetrahydrobiopterin (BH4) serve as cofactors for indoleamine 2,3-dioxygenase isolated from mouse epididymis. The optimal pH was between 7 and 8, and FMNH2-dependent activity was 4 to 5-fold higher than activity with methylene blue as the electron donor. Using FMNH2 with a FMN r...

journal_title：Biochemical and biophysical research communications

authors： Ozaki Y,Reinhard JF Jr,Nichol CA

更新日期：1986-06-30 00:00:00

abstract：:Using a human placenta cDNA library, we cloned a novel member belonging to the scavenger receptor family. Complementary DNA of this clone encodes a type II transmembranous glycoprotein containing a collagen-like domain, which are typical structural characteristics of scavenger receptor class A. This protein also conta...

journal_title：Biochemical and biophysical research communications

authors： Nakamura K,Funakoshi H,Miyamoto K,Tokunaga F,Nakamura T

更新日期：2001-02-02 00:00:00

abstract：:Using recombinant DNA technology, the NH2 and COOH terminal domains of the human Factor VIII molecule were co-expressed in baby hamster kidney 21 (BHK21) cells using the vaccinia virus system. Procoagulant activity was detectable in cell supernatants, thus suggesting that the central portion present in the FVIII prote...

journal_title：Biochemical and biophysical research communications

authors： Pavirani A,Meulien P,Harrer H,Dott K,Mischler F,Wiesel ML,Mazurier C,Cazenave JP,Lecocq JP

更新日期：1987-05-29 00:00:00

abstract：:Cardiac fibrosis is an important cardiac remodeling event in the development of inflammation dilated cardiomyopathy （iDCM）. We have previously observed that degradation enhancer of androgen receptor (ASC-J9®) could improve cardiac inflammation and fibrosis. Using Primary CFs, we demonstrated that ASC-J9® attenuates th...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Ma W,Lu S,Yan L,Hu F,Wang Z,Cheng B

更新日期：2018-11-17 00:00:00

abstract：:Astrocytes play key roles in the central nervous system and regulate local blood flow and synaptic transmission via intracellular calcium (Ca2+) signaling. Astrocytic Ca2+ signals are generated by multiple pathways: Ca2+ release from the endoplasmic reticulum (ER) via the inositol 1, 4, 5-trisphosphate receptor (IP3R)...

journal_title：Biochemical and biophysical research communications

authors： Sakuragi S,Niwa F,Oda Y,Mikoshiba K,Bannai H

更新日期：2017-05-13 00:00:00

abstract：:Multidrug resistance protein 2 (Mrp2) is considered the major mammalian membrane transporter of non-bile salt organic anions from liver to bile. Using Mrp2-deficient rats, we show that the protein is not essential for biliary excretion of biliverdin, its IIIalpha and XIIIalpha isomers, mesobiliverdin XIIIalpha or bili...

journal_title：Biochemical and biophysical research communications

authors： McDonagh AF,Lightner DA,Kar AK,Norona WS

更新日期：2002-05-10 00:00:00

abstract：INTRODUCTION:Chemical intervention of autophagy has been investigated in clinical trials for various age-related conditions such as sarcopenia and neurodegeneration. However, at present, no autophagy inducer has been established as a disease-modifying agent against neurodegenerative diseases. METHODS:We screened a lib...

journal_title：Biochemical and biophysical research communications

authors： Hirano K,Fujimaki M,Sasazawa Y,Yamaguchi A,Ishikawa KI,Miyamoto K,Souma S,Furuya N,Imamichi Y,Yamada D,Saya H,Akamatsu W,Saiki S,Hattori N

更新日期：2019-10-08 00:00:00

abstract：:We proposed to use a novel stepwise sequence-constructive SELEX method to develop DNA aptamers that can recognize Globo H which is a tumor-associated carbohydrate antigen. A combinatorial synthetic library that consisted of DNA molecules with randomized regions of 15-bases was used as the starting library for the firs...

journal_title：Biochemical and biophysical research communications

authors： Wang CY,Wu CY,Hung TC,Wong CH,Chen CH

更新日期：2014-09-26 00:00:00

abstract：:S-100 protein and annexin II2-p11(2) were reported to inhibit and to stimulate the assembly of glial fibrillary acidic protein (GFAP), respectively, in a Ca(2+)-dependent manner. Here we show by a number of experimental approaches that S-100 protein contrasts all the effects of annexin II2-p11(2) on GFAP assembly and,...

journal_title：Biochemical and biophysical research communications

authors： Bianchi R,Garbuglia M,Verzini M,Giambanco I,Spreca A,Donato R

更新日期：1995-03-28 00:00:00

abstract：:A number of genes have been identified in the fully sequenced genome of Saccharomyces cerevisiae that appear to be conserved throughout evolution and the function of which remains poorly understood. In this manuscript we describe the initial characterization of yeast BUD31 gene. cDNA sequences highly related to BUD31 ...

journal_title：Biochemical and biophysical research communications

authors： Masciadri B,Areces LB,Carpinelli P,Foiani M,Draetta G,Fiore F

更新日期：2004-08-06 00:00:00

abstract：:Mitochondria isolated from rats chronically fed ethanol were more sensitive to induction of the mitochondrial permeability transition (MPT) by a variety of agents than mitochondria isolated from isocalorically matched controls. The agents utilized have been implicated in both necrotic (Ca(2+)) and apoptotic (ceramide,...

journal_title：Biochemical and biophysical research communications

authors： Pastorino JG,Marcineviciute A,Cahill A,Hoek JB

更新日期：1999-11-19 00:00:00

abstract：:A combination of a radiotherapeutic regimen with telomerase inhibition is valuable when tumor cells are to be sensitized to radiation. Here, we describe cell clones unresponsive to radiosensitization after telomere shortening. After extensive division of individual transformed clones of mTERC-/- cells, about 22% of cl...

journal_title：Biochemical and biophysical research communications

authors： Ju YJ,Shin HJ,Park JE,Juhn KM,Woo SR,Kim HY,Han YH,Hwang SG,Hong SH,Kang CM,Yoo YD,Park WB,Cho MH,Park GH,Lee KH

更新日期：2010-11-12 00:00:00

abstract：:Most human cancers are of epithelial origin, but many cell culture models for the study of cancer-causing genes use fibroblasts. In addition, efficient delivery and stable expression of foreign genes into non-transformed cell lines are often difficult. To address both questions, we here established a non-transformed r...

journal_title：Biochemical and biophysical research communications

authors： Fu SL,Huang YJ,Liang FP,Huang YF,Chuang CF,Wang SW,Yao JW

更新日期：2005-12-16 00:00:00

abstract：:Estrogen-Estrogen Receptor alpha (ERα) belongs to one of the most important signaling pathways controlling breast tissue development and progression of breast cancer. ERRF was recently identified as a candidate breast cancer associated protein and showed positive association with ERα status in clinical samples and cel...

journal_title：Biochemical and biophysical research communications

authors： Luo A,Zhang X

更新日期：2016-05-27 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) promotes vasculogenesis, arteriogenesis, and angiogenesis by stimulating proliferation, migration, and cell survival of endothelial cells. VEGF mediates its actions through activation of two receptor tyrosine kinases, VEGFR-1 and VEGFR-2. Serum starvation led to apoptosis of h...

journal_title：Biochemical and biophysical research communications

authors： Yilmaz A,Kliche S,Mayr-Beyrle U,Fellbrich G,Waltenberger J

更新日期：2003-07-04 00:00:00

abstract：:The Br140 protein was initially identified due to its co-purification with an integrin. We have cloned and sequenced the cDNA corresponding to the Br140 protein. Analysis of the amino acid sequence indicates that Br140 has features characteristic of gene regulatory proteins, including zinc fingers. Furthermore, Br140 ...

journal_title：Biochemical and biophysical research communications

authors： Thompson KA,Wang B,Argraves WS,Giancotti FG,Schranck DP,Ruoslahti E

更新日期：1994-02-15 00:00:00

abstract：:Lipopolysaccharides (LPS) of Porphyromonas gingivalis have been implicated in the initiation and development of periodontal diseases. In a previous study, we investigated the signal transduction pathway of P. gingivalis and demonstrated that LPS stimulates the production of interleukin (IL)-6 in human gingival fibrobl...

journal_title：Biochemical and biophysical research communications

authors： Wang PL,Shirasu S,Shinohar M,Azuma Y,Daito M,Yasuda H,Ohura K

更新日期：1999-09-24 00:00:00

abstract：:Fatty Acid Synthase (FASN), a 250-kDa cytosolic multi-enzyme catalyzing eukaryotic de novo FA biogenesis, unexpectedly localizes in cancer cell culture supernatants and in the blood of cancer patients. High levels of "extracellular FASN" have recently been found in supernatants from Hepatitis C Virus-infected liver ce...

journal_title：Biochemical and biophysical research communications

authors： Oliveras-Ferraros C,Vazquez-Martin A,Fernández-Real JM,Menendez JA

更新日期：2009-01-16 00:00:00

abstract：:The Rh blood group antigens are carried by two distinct but homologous membrane proteins encoded by two closely related genes, RCHE and RHD. Rh50 glyco-protein is the membrane protein tightly associated with Rh polypeptides and is critical for expression of Rh antigens. The amino acid sequence and predicted membrane t...

journal_title：Biochemical and biophysical research communications

authors： Iwamoto S,Omi T,Yamasaki M,Okuda H,Kawano M,Kajii E

更新日期：1998-02-04 00:00:00

abstract：:Farnesoid X receptor (FXR) belongs to the ligand-activated nuclear receptor superfamily, and functions as a transcription factor regulating the transcription of numerous genes involved in bile acid homeostasis, lipoprotein and glucose metabolism. In the present study, we identified RECK, a membrane-anchored inhibitor ...

journal_title：Biochemical and biophysical research communications

authors： Peng X,Wu W,Zhu B,Sun Z,Ji L,Ruan Y,Zhou M,Zhou L,Gu J

更新日期：2014-01-03 00:00:00

abstract：:RNA interference (RNAi) mediated inhibition of virus-specific genes has emerged as a potential therapeutic strategy against virus induced diseases. Human hepatitis B virus (HBV) surface antigen (HBsAg) has proven to be a significant risk factor in HBV induced liver diseases, and an increasing number of mutations in HB...

journal_title：Biochemical and biophysical research communications

authors： Cheng TL,Chang WW,Su IJ,Lai MD,Huang W,Lei HY,Chang WT

更新日期：2005-10-28 00:00:00

abstract：:We developed a typing assay for HIV-1 using subtype specific peptides corresponding to the five major subtypes of HIV-1 (A to E). In eight patients serologically subtyped as A (n = 1), B (n = 3), C (n = 3) and E (n = 1) phyllogenetic analysis of sequenced V3 domain DNA completely correlated to the peptide serotyping. ...

journal_title：Biochemical and biophysical research communications

authors： Sherefa K,Sönnerborg A,Steinbergs J,Sällberg M

更新日期：1994-12-30 00:00:00

abstract：:Mitochondrial porins or VDACs (voltage-dependent anion-selective channels) are transmembrane pore-forming proteins. In eukaryotic genomes multiple genes coding for VDAC homologues have been discovered, but their function remains unknown. In Drosophila melanogaster three additional genes homologous to the gene porin ha...

journal_title：Biochemical and biophysical research communications

authors： Guarino F,Specchia V,Zapparoli G,Messina A,Aiello R,Bozzetti MP,De Pinto V

更新日期：2006-08-04 00:00:00

abstract：:The ornithine decarboxylase gene of S. cerevisiae encodes a predicted protein of approximately 53 kD highly homologous with the ornithine decarboxylase of other species. However, the native enzyme has been reported as an 86 kD protein. Our molecular sieve analysis indicated a Mr = 110,000 for the native enzyme. SDS-PA...

journal_title：Biochemical and biophysical research communications

authors： Fonzi WA

更新日期：1989-08-15 00:00:00

abstract：:Neutrophil extracellular traps (NETs) play a critical role in host antimicrobial response whereas they are also implicated in the pathogenesis of inflammatory and autoimmunediseases. Generation of reactiveoxygen species (ROS) is key to NETs formation. A variety of stimulatory ligands have been found to enhance ROS pro...

journal_title：Biochemical and biophysical research communications

authors： Zhu Y,Yang Y,Li F,Fan S,Chen X,Lu Y,Wei Y,Chen Q,Xia L,Tang J,Huang Q,Zhu Q,Zheng J,Liu X

更新日期：2019-04-16 00:00:00

abstract：:Parenteral immunization of transgenic mouse models of Alzheimer disease (AD) with synthetic amyloid beta-peptide (Abeta) prevented or reduced Abeta deposits and attenuated their memory and learning deficits. A clinical trial of immunization with synthetic Abeta, however, was halted due to brain inflammation, presumabl...

journal_title：Biochemical and biophysical research communications

authors： Fukuchi K,Accavitti-Loper MA,Kim HD,Tahara K,Cao Y,Lewis TL,Caughey RC,Kim H,Lalonde R

更新日期：2006-05-26 00:00:00

abstract：:High performance liquid chromatographic (HPLC) analysis showed that the prototype antioxidant ascorbate (vitamin C) inhibits the DNA adducts induced by synthetic estrogen diethylstilbestrol (DES) and the antiestrogen metabolite 4-hydroxytamoxifen (4-OHTam). Treatment of salmon testes DNA with 4-OHTam quinone or 4-OHTa...

journal_title：Biochemical and biophysical research communications

authors： Sharma M,Slocum HK

更新日期：1999-09-07 00:00:00

abstract：:Binding of cytochrome b5 to rat cytochrome P450 2B1 was inhibited (by 75%) by a synthetic peptide corresponding to P450 residues 116-134. The role of Lys-122 and Arg-125 were evaluated using peptides in which one or both of these basic residues were replaced with Glu. The Lys-122 substitution nearly abolished while th...

journal_title：Biochemical and biophysical research communications

authors： Omata Y,Sakamoto H,Robinson RC,Pincus MR,Friedman FK

更新日期：1994-06-30 00:00:00

abstract：:To investigate whether residues in the extracellular domains of melanocortin 1 receptor (MC1R) are required for ligand binding, a number of mutants were constructed where charged residues were converted to alanine. The residues targeted for mutagenesis were Ser6, Glu102, Arg109, Asp184, Glu269, and Thr272. The mutant ...

journal_title：Biochemical and biophysical research communications

authors： Chhajlani V,Xu X,Blauw J,Sudarshi S

更新日期：1996-02-15 00:00:00

abstract：:Glucuronidated and/or methylated metabolites of the proanthocyanidin (PA) monomer (-)-epicatechin are detected in both blood and brain following feeding of rodents with a monomeric grape seed PA extract shown to reduce symptoms in a mouse model of Alzheimer's disease. To generate metabolites for future mechanistic stu...

journal_title：Biochemical and biophysical research communications

authors： Blount JW,Ferruzzi M,Raftery D,Pasinetti GM,Dixon RA

更新日期：2012-01-06 00:00:00