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BR140, a novel zinc-finger protein with homology to the TAF250 subunit of TFIID.

Abstract：

:The Br140 protein was initially identified due to its co-purification with an integrin. We have cloned and sequenced the cDNA corresponding to the Br140 protein. Analysis of the amino acid sequence indicates that Br140 has features characteristic of gene regulatory proteins, including zinc fingers. Furthermore, Br140 has a homology to a family of transcriptional co-activators, one of which is a characterized component of the general transcriptional machinery. Immunologic studies indicate that Br140 has a broad tissue distribution and is abundant in testes and spermatogonia. Br140 is primarily a nuclear protein. These results suggest that Br140 may be a part of the general transcriptional machinery.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Thompson KA,Wang B,Argraves WS,Giancotti FG,Schranck DP,Ruoslahti E

doi

10.1006/bbrc.1994.1162

subject

Has Abstract

pub_date

1994-02-15 00:00:00

pages

1143-52

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X84711624

journal_volume

198

pub_type

杂志文章

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