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Clonal cell populations unresponsive to radiosensitization induced by telomerase inhibition.

Abstract：

:A combination of a radiotherapeutic regimen with telomerase inhibition is valuable when tumor cells are to be sensitized to radiation. Here, we describe cell clones unresponsive to radiosensitization after telomere shortening. After extensive division of individual transformed clones of mTERC-/- cells, about 22% of clones were unresponsive to radiosensitization even though telomerase action was inhibited. The telomere lengths of unsensitized mTERC-/- clones were reduced, as were those of most sensitized clones. However, the unsensitized clones did not exhibit chromosomal end-to-end fusion to the extent noted in all sensitized clones. Thus, a defense mechanism preventing telomere erosion is operative even when telomeres become shorter under conditions of telomerase deficiency, and results in unresponsiveness to the radiosensitization generally mediated by telomere shortening.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ju YJ,Shin HJ,Park JE,Juhn KM,Woo SR,Kim HY,Han YH,Hwang SG,Hong SH,Kang CM,Yoo YD,Park WB,Cho MH,Park GH,Lee KH

doi

10.1016/j.bbrc.2010.09.091

subject

Has Abstract

pub_date

2010-11-12 00:00:00

pages

198-202

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)01801-2

journal_volume

402

pub_type

杂志文章

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