Transcriptional regulation of gamma-glutamylcysteine synthetase-heavy subunit by oxidants in human alveolar epithelial cells.

abstract：:After screening the data base of the Berkeley Drosophila Genome Project with a sequence coding for the transmembrane region of a G protein-coupled receptor, we found that Drosophila might contain a gene coding for a receptor that is structurally related to the Gonadotropin-Releasing Hormone (GnRH) receptors from verte...

journal_title：Biochemical and biophysical research communications

authors： Hauser F,Søndergaard L,Grimmelikhuijzen CJ

更新日期：1998-08-28 00:00:00

abstract：:The K-sam gene was first identified as an amplified gene in the poorly differentiated types, especially in the scirrhous type, of gastric cancers. We have recently found and reported that the carboxyl-terminal exons of K-sam are frequently deleted in the scirrhous type of gastric cancer. The deletion generates prefere...

journal_title：Biochemical and biophysical research communications

authors： Ueda T,Sasaki H,Aoyagi K,Narikiyo M,Tsubosa Y,Kuwahara Y,Sakamoto H,Mafune K,Yoshida T,Makuuchi M,Terada M

更新日期：1999-11-30 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) promotes vasculogenesis, arteriogenesis, and angiogenesis by stimulating proliferation, migration, and cell survival of endothelial cells. VEGF mediates its actions through activation of two receptor tyrosine kinases, VEGFR-1 and VEGFR-2. Serum starvation led to apoptosis of h...

journal_title：Biochemical and biophysical research communications

authors： Yilmaz A,Kliche S,Mayr-Beyrle U,Fellbrich G,Waltenberger J

更新日期：2003-07-04 00:00:00

abstract：:The RNA binding proteins (RBPs) have multiple roles in human cancer. However, their molecular target and function have not been clearly identified. Our genomic analysis derived from patients reveals that NONO is a potential oncogenic gene in lung cancer. NONO is highly expressed in lung cancer tissues compared with no...

journal_title：Biochemical and biophysical research communications

authors： Kim SJ,Ju JS,Park SS,Suh YA,Yoo HJ,Choi EK,Seong-Yun Jeong,Shin Y,Park YY

更新日期：2020-07-23 00:00:00

abstract：:Bovine embryonic stem-like cells (ES-like cells) appear to maintain a normal diploid karyotype indefinitely during culture in vitro and to express marker proteins that are characteristic of ES cells from mice, namely, alkaline phosphatase (AP), stage-specific embryonic antigen-1 (SSEA-1), STAT-3, and Oct 4. After prol...

journal_title：Biochemical and biophysical research communications

authors： Saito S,Sawai K,Ugai H,Moriyasu S,Minamihashi A,Yamamoto Y,Hirayama H,Kageyama S,Pan J,Murata T,Kobayashi Y,Obata Y,Yokoyama KK

更新日期：2003-09-12 00:00:00

abstract：:The alternatively spliced isoform of the nonmuscle myosin II heavy chain B (MHC-B) with an insert of 21 amino acids at the 50- to 20-kDa junction of the globular region of myosin has been demonstrated to be expressed specifically in the central nervous system (CNS) in chicken. To explore the role of this B2 inserted i...

journal_title：Biochemical and biophysical research communications

authors： Takahashi M,Hirano T,Uchida K,Yamagishi A

更新日期：1999-05-27 00:00:00

abstract：:Streptomyces toyocaensis NRRL 15009 produces A47934, a glycopeptide antibiotic. This compound is composed of several unusual amino acids, some of which have chlorinated aromatic rings. We have isolated two distinct halogenating enzymes, a chloroperoxidase (42,882 Da) and a catalase/bromoperoxidase (53,890 Da), from la...

journal_title：Biochemical and biophysical research communications

authors： Marshall GC,Wright GD

更新日期：1996-02-15 00:00:00

abstract：:Almost all bacteria require iron for growth and virulence expression. However, Listeria spp. do not produce any siderophore for iron acquisition. Representative strains of each of the six species of Listeria were examined for their ability to use various compounds as iron suppliers in iron-restricted medium. Here we s...

journal_title：Biochemical and biophysical research communications

authors： Coulanges V,Andre P,Vidon DJ

更新日期：1998-08-19 00:00:00

abstract：:Vertebrate homeobox genes have been identified on the basis of sequence homology to Drosophila segmentation and homeotic genes. We have analyzed the spatial distribution patterns in hatching larvae of transcripts from two different types of zebrafish (Brachydanio rerio) homeobox genes. Tritiated DNA fragments from one...

journal_title：Biochemical and biophysical research communications

authors： Njølstad PR,Fjose A

更新日期：1988-12-15 00:00:00

abstract：:Within the first external loop of mouse and human TRESK subunits one or two N-glycosylation consensus sites were identified, respectively. Using site directed mutagenesis and Western immunoblotting a single residue of both orthologues was found to be glycosylated upon heterologous expression. Two-electrode voltage-cla...

journal_title：Biochemical and biophysical research communications

authors： Egenberger B,Polleichtner G,Wischmeyer E,Döring F

更新日期：2010-01-08 00:00:00

abstract：:The ontogeny of T-Kininogen expression in the rat liver was examined. Levels approximately 6 fold higher than seen in the adult liver are present during the perinatal period. Elevated levels are also seen in the maternal liver, beginning 5 days prior to parturition. The timing of induction in the fetal and maternal li...

journal_title：Biochemical and biophysical research communications

authors： Mann EA,Lingrel JB

更新日期：1991-01-31 00:00:00

abstract：:Activation of seven-transmembrane G-protein coupled receptor (GPCR) mediates extracellular signals into intracellular responses. G-protein coupled receptor 55 (GPR55) is one of GPCRs and activated by endogenous cannabinoids. A family of regulators of G-protein signaling (RGS) stimulates GTP hydrolysis of alpha subunit...

journal_title：Biochemical and biophysical research communications

authors： Jang H,Kim Y,Ghil S

更新日期：2020-12-17 00:00:00

abstract：:A sample of highly oriented Na-hyaluronate was prepared with a wet--spinning method and equilibrated to 75% relative humidity. Its proton NMR spectrum was recorded as a function of the angle theta between the hyaluronate helix axis and the external magnetic field. It appeared as a singlet with an angle-dependent line ...

journal_title：Biochemical and biophysical research communications

authors： Lahajnar G,Rupprecht A

更新日期：1986-11-26 00:00:00

abstract：:We present a novel and useful principle that can be applied to enzyme reactions with dilute substrates and enables to obtain the desired time-course curve from the reverse reaction when the latter can be measured more easily. Let us imagine an enzyme mixture that can catalyze the interconversion between substances A, ...

journal_title：Biochemical and biophysical research communications

authors： Kijima S,Kijima H

更新日期：1994-09-15 00:00:00

abstract：:Low molecular weight-PTP has been reported as a redox-sensitive protein during both platelet-derived growth factor and integrin signalling. In response to oxidation the phosphatase undergoes a reversible inactivation, which in turn leads to the increase in tyrosine phosphorylation of its substrates and the properly ex...

journal_title：Biochemical and biophysical research communications

authors： Giannoni E,Raugei G,Chiarugi P,Ramponi G

更新日期：2006-09-22 00:00:00

abstract：:The VEGFs and FGF-2 stimulate angiogenesis. Pigment epithelium-derived factor (PEDF) and thrombospondin-1 (TSP-1) strongly inhibit angiogenesis. Human umbilical vein endothelial cells (HUVECs) expressed VEGF-A, -B, -C, the VEGF receptors R1, R2, and R3, PEDF, FGF-2, and TSP-1, but VEGF-D transcripts were barely detect...

journal_title：Biochemical and biophysical research communications

authors： Aparicio S,Sawant S,Lara N,Barnstable CJ,Tombran-Tink J

更新日期：2005-01-14 00:00:00

abstract：:We cloned two novel types of TEA domain-containing transcription factor (ETFR-1 and -2) cDNAs. Amino acid sequences deduced for ETFR-1 and -2 as well as those of other known proteins of the same family, TEF-1 and ETF, exhibited significant identity (63-75% overall) to each other not only in the TEA DNA binding domain ...

journal_title：Biochemical and biophysical research communications

authors： Yasunami M,Suzuki K,Ohkubo H

更新日期：1996-11-12 00:00:00

abstract：:The synthesis of toxin protein from Ustilago maydis virus (UmV) strain P4 was studied in vitro and in vivo. The protein synthesized in vitro and in vivo has a molecular weight of approximately 30 kd whereas the native toxin has a molecular weight of about 12 kd. In the presence of protease inhibitors and glycosylation...

journal_title：Biochemical and biophysical research communications

authors： Podila GK,Bozarth RF,Flurkey WH

更新日期：1987-12-16 00:00:00

abstract：:Epithelin/granulin growth factor is synthesized as a 593 amino acid precursor protein that contains 7.5 imperfectly conserved repeats of approximately 57 amino acids. Processed epithelin/granulin peptides have been isolated from vertebrate/invertebrate species and are growth factors implicated in epithelial and haemic...

journal_title：Biochemical and biophysical research communications

authors： Trinh DP,Brown KM,Jeang KT

更新日期：1999-03-16 00:00:00

abstract：:Oxidants and inflammatory mediators such as tumour necrosis factor-alpha (TNF-alpha) activate transcription factors such as NF-kappa B. Interleukin-8 (IL-8) is a ubiquitous inflammatory chemokine that mediates a multitude of inflammatory events in the lung. Ergothioneine is a naturally occurring thiol compound, which ...

journal_title：Biochemical and biophysical research communications

authors： Rahman I,Gilmour PS,Jimenez LA,Biswas SK,Antonicelli F,Aruoma OI

更新日期：2003-03-21 00:00:00

abstract：:The death of cardiomyocytes after myocardial infarction (MI) often leads to ventricular remodeling as well as heart failure (HF). The cardiac progenitor cells (CPCs) have the ability to regenerate functional heart muscle in patients after MI, which provides a promising method for MI-induced HF therapy. However, to dat...

journal_title：Biochemical and biophysical research communications

authors： Li L,Wang Q,Yuan Z,Chen A,Liu Z,Wang Z,Li H

更新日期：2018-05-15 00:00:00

abstract：:The effect of 1-bromlalkanes on intracellular glutathione (GSH) was studied in freshly isolated rat hepatocytes. Treatment of cells with bromoalkanes depleted cellular GSH levels without causing cytotoxicity. The extent of GSH depletion was directly proportional to the concentration and increasing chain length of 1-br...

journal_title：Biochemical and biophysical research communications

authors： Khan S,O'Brien PJ

更新日期：1991-08-30 00:00:00

abstract：:Pro-aminopeptidase processing protease (PA protease) is an extracellular zinc metalloprotease produced by Aeromonas caviae T-64 and it is classified as M04.016 according to the MEROPS database. The precursor of PA protease consists of four regions; a signal peptide, an N-terminal propeptide, a C-terminal propeptide, a...

journal_title：Biochemical and biophysical research communications

authors： Tang B,Nirasawa S,Kitaoka M,Hayashi K

更新日期：2002-08-09 00:00:00

abstract：:The MoFe protein of the complex metalloenzyme nitrogenase folds as a heterotetramer containing two copies each of the homologous alpha and beta subunits, encoded by the nifD and the nifK genes respectively. Recently, the functional expression of a fusion NifD-K protein of nitrogenase was demonstrated in Azotobacter vi...

journal_title：Biochemical and biophysical research communications

authors： Lahiri S,Pulakat L,Gavini N

更新日期：2005-11-18 00:00:00

abstract：:Excessive oxidative stress induces significant injury and cytotoxicity to neuronal cells. The current study tested expression and the potential function of the circular RNA PRKCI (circPRKCI) in oxidative stress-injured neuronal cells. In cultured SH-SY5Y neuronal cells, hydrogen peroxide (H2O2) downregulated circPRKCI...

journal_title：Biochemical and biophysical research communications

authors： Cheng Q,Cao X,Xue L,Xia L,Xu Y

更新日期：2019-06-25 00:00:00

abstract：:The rSK3 gene encodes a small conductance Ca(2+)-activated K(+) channel that is transcriptionally regulated by estrogen. To examine determinants of rSK3 gene expression, the CAP site was defined and the promoter was identified. A 33 bp sequence adjacent to the promoter was shown to act as an enhancer in L6 cells that ...

journal_title：Biochemical and biophysical research communications

authors： Jacobson D,Pribnow D,Herson PS,Maylie J,Adelman JP

更新日期：2003-04-04 00:00:00

abstract：:Cellular response to oxidative stress is a complex process that is often connected to cell cycle regulation. The present study examines the effect of H(2)O(2) on cell cycle regulation and involvement of reactive oxygen species (ROS) in these H(2)O(2)-induced responses in a p53-deficient human lung carcinoma cell line,...

journal_title：Biochemical and biophysical research communications

authors： Chung YW,Jeong DW,Won JY,Choi EJ,Choi YH,Kim IY

更新日期：2002-05-17 00:00:00

abstract：:The objective of the experiments described in this paper was to test the potential of antisense RNAs complementary to the internal portion of an intron to inhibit the splicing process and to determine the mechanism of such inhibition. The results obtained indicate that RNA fragments complementary to the internal porti...

journal_title：Biochemical and biophysical research communications

authors： Volloch V,Schweitzer B,Rits S

更新日期：1991-09-30 00:00:00

abstract：:Dopamine D4 receptor (DRD4) has received attention in terms of pathogenesis of schizophrenia and association with human personalities. We isolated the human DRD4 gene containing the 5'-flanking region and determined its sequence. Analysis of the DRD4 transcripts by 5'-RACE (5'-rapid amplification of cDNA ends) reveale...

journal_title：Biochemical and biophysical research communications

authors： Kamakura S,Iwaki A,Matsumoto M,Fukumaki Y

更新日期：1997-06-18 00:00:00

abstract：:The present study provides the first evidence that nitropolycyclic aromatic hydrocarbons such as 1-nitropyrene and 2-nitrofluorene are metabolized to the corresponding formylamino compounds in animal bodies. The study shows that the formation of such novel metabolites, 1-formylaminopyrene and 2-formylaminofluorene, is...

journal_title：Biochemical and biophysical research communications

authors： Tatsumi K,Amano H

更新日期：1987-01-30 00:00:00