当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Involvement of P2X4 receptor in P2X7 receptor-dependent cell death of mouse macrophages.

Involvement of P2X4 receptor in P2X7 receptor-dependent cell death of mouse macrophages.

Abstract：

:Interaction of P2X7 receptor with P2X4 receptor has recently been suggested, but it remains unclear whether P2X4 receptor is involved in P2X7 receptor-mediated events, such as cell death of macrophages induced by high concentrations of extracellular ATP. Here, we present evidence that P2X4 receptor does play a role in P2X7 receptor-dependent cell death. Treatment of mouse macrophage RAW264.7 cells with 1mM ATP induced Ca(2+) influx, non-selective large pore formation, activation of extracellular signal-regulated protein kinase (ERK) 1/2 and p38 mitogen-activated protein kinase (MAPK), and cell death via activation of P2X7 receptor. P2X4-knockdown cells, established by transfecting RAW264.7 cells with two short hairpin RNAs (shRNAs) targeting P2X4 receptor, showed a decrease of the initial peak of intracellular Ca(2+) after treatment with ATP, though pore formation and the P2X7-mediated activation of ERK1/2 and p38 MAPK were not affected. Intriguingly, P2X4 knockdown resulted in significant suppression of cell death induced by ATP or P2X7 agonist BzATP. In conclusion, our results suggest that P2X4 receptor is involved in P2X7 receptor-mediated cell death, but not pore formation or MAPK signaling.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kawano A,Tsukimoto M,Noguchi T,Hotta N,Harada H,Takenouchi T,Kitani H,Kojima S

doi

10.1016/j.bbrc.2012.01.156

subject

Has Abstract

pub_date

2012-03-09 00:00:00

pages

374-80

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(12)00249-5

journal_volume

419

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Identification of a prealbumin variant in the serum of a Japanese patient with familial amyloidotic polyneuropathy.

    abstract：:Serum prealbumin isolated from a Japanese patient with familial amyloidotic polyneuropathy (FAP) has been found to consist of a mixture of normal prealbumin and a prealbumin variant which contains a methionine for valine substitution at position 30. The prealbumin variant in the serum is identical to the prealbumin va...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(84)80092-3

    authors： Nakazato M,Kangawa K,Minamino N,Tawara S,Matsuo H,Araki S

    更新日期：1984-07-31 00:00:00

  • Overexpression of MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10.

    abstract：:Alzheimer's disease (AD) is characterized by the deposition of β-amyloid (Aβ) peptide in the brain, which is produced by the proteolysis of β-amyloid precursor protein (APP). Recently, the mitochondrial transcription factor 4 (MTERF4), a member of the MTERF family, was implicated in regulating mitochondrial DNA transc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.11.135

    authors： Wang XL,Liu Q,Chen GJ,Li ML,Ding YH

    更新日期：2017-01-22 00:00:00

  • ZNF436 promotes tumor cell proliferation through transcriptional activation of BCL10 in glioma.

    abstract：:Transcriptional factors (TFs) are key regulators in orchestrating gene transcription during cancer development. However, their roles in glioma remain elusive. Here, we analyzed the differential expression of TFs and identified ZNF436 is upregulated in glioblastoma and Lower Grade Glioma patients. High expression of ZN...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.06.004

    authors： Shang Y,Li Y,Zhang Y,Wang J

    更新日期：2019-08-06 00:00:00

  • Bortezomib sensitizes human glioblastoma cells to induction of apoptosis by type I interferons through NOXA expression and Mcl-1 cleavage.

    abstract：:Glioblastomas are highly invasive and aggressive primary brain tumors. Type I interferons have significant, pleiotropic anticancer activity. However, through various pathways many cancers become interferon-resistant, limiting interferon's clinical utility. In this study, we demonstrated that the proteasomal inhibitor ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.07.080

    authors： Wang R,Davidoff AM,Pfeffer LM

    更新日期：2016-09-09 00:00:00

  • Highly expressed lncRNA CCND2-AS1 promotes glioma cell proliferation through Wnt/β-catenin signaling.

    abstract：:Glioma is the most common and aggressive primary brain tumor in adults. Long-non coding RNAs (lncRNAs) have been recently shown to play important roles in regulating numerous biological processes both in physiologic and pathologic condition. However, the role of lncRNAs in glioma remains largely unknown. In this study...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.12.016

    authors： Zhang H,Wei DL,Wan L,Yan SF,Sun YH

    更新日期：2017-01-22 00:00:00

  • Glutathione S-transferase in yeast: induction of mRNA, cDNA cloning and expression in Escherichia coli.

    abstract：:Glutathione S-transferase Y-2 mRNA synthesis was induced in yeast Issatchenkia orientalis approximately 37-fold by cultivation with o-dinitrobenzene. A cDNA library complementary to poly (A)+RNA of I. orientalis grown with o-dinitrobenzene was screened by colony hybridization. Twenty positive clones were obtained from...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)90726-4

    authors： Tamaki H,Kumagai H,Tochikura T

    更新日期：1990-10-30 00:00:00

  • A new method for rapid assignment of S-S bridges in proteins.

    abstract：:A new method for complementing existing protein chemical techniques for the assignment of S-S bridge positions in amino-acid sequences is described. The principle of the method is the direct examination of the masses of protein fragments, obtained by chemical or enzymatic degradation. Proteins are digested under condi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)90302-x

    authors： Morris HR,Pucci P

    更新日期：1985-02-15 00:00:00

  • Downregulation of the cdc2/cyclin B protein kinase activity by binding of p53 to p34(cdc2).

    abstract：:We previously found that p53 binds to the catalytic subunit of the p34(cdc2)/cyclin B1-kinase. In the present study we analyzed the functional consequences of this interaction. Binding of wild-type p53 to p34(cdc2)/cyclin B1 results in a significant decrease of its histone H1 kinase activity. Binding of p53 to the kin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4792

    authors： Ababneh M,Götz C,Montenarh M

    更新日期：2001-05-04 00:00:00

  • Functional inhibition of fatty acid binding protein 4 ameliorates impaired ciliogenesis in GCs.

    abstract：:Ciliogenesis is often impaired in some cancer cells, leading to acceleration of cancer phenotypes such as cell migration and proliferation. From the investigation of primary cilia of 16 gastric cancer cells (GCs), we found that GCs could be grouped into four primary cilia (PC)-positive GCs and 12 PC-negative GCs. The ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.12.083

    authors： Jung Y,Cho SM,Kim S,Cheong JH,Kwon HJ

    更新日期：2021-02-05 00:00:00

  • 8-azaguanosine-5'-monophosphate synthesis via nucleoside kinase in cultured Chinese hamster lung fibroblasts.

    abstract：:Cultured chinese hamster lung fibroblasts, and a variant clone selected for resistance to 8-azaguanine, that lacks hypoxanthine-guanine phosphoribosyl transferase (EC 2.4.2.8), have been tested for the ability to convert 8-azaguanine into 8-azaguanosine-5'-monophosphate via purine nucleoside phosphorylase and nucleosi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)90073-9

    authors： Tozzi MG,Camici M,Falcone V,Turriani M,Turchi G,Ipata PL

    更新日期：1989-03-15 00:00:00

  • Biochemical and morphological classification of disease-associated alpha-synuclein mutants aggregates.

    abstract：:Alpha-synuclein (a-syn) aggregation in brain is implicated in several synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Until date, at least six disease-associated mutations in a-syn (namely A30P, E46K, H50Q, G51D, A53T, and A53E) are known to ca...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.11.200

    authors： Tanaka G,Yamanaka T,Furukawa Y,Kajimura N,Mitsuoka K,Nukina N

    更新日期：2019-01-15 00:00:00

  • Semaphorin-3F attracts the growth cone of cerebellar granule cells through cGMP signaling pathway.

    abstract：:Growth cone extension is guided by extracellular factors during the brain development but the underlying cellular mechanisms remain largely unclear. Here, we examined the potential function of class-3 semaphorins in cultured cerebellar granule cells. We found neuropilin-2 (NP2), the high-affinity receptor for semaphor...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.03.073

    authors： Ding S,Luo JH,Yuan XB

    更新日期：2007-05-18 00:00:00

  • Inactivation of human blood coagulation factor X by chemical modification of gamma-carboxyglutamic acid residues.

    abstract：:The inactivation of human factor X by incubation with a reagent known to chemically modify gamma-carboxyglutamic acid to gamma-methylene glutamic acid was studied. Incubation of factor X at pH 5.0 with a preincubated formaldehyde/morpholine mixture (0.9 M/1.0 M) resulted in a progressive decrease in factor X coagulant...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)90945-8

    authors： Sherrill GB,Straight DL,Hiskey RG,Roberts HR,Griffith MJ

    更新日期：1984-10-15 00:00:00

  • Action of apoptotic endonuclease DNase gamma on naked DNA and chromatin substrates.

    abstract：:The internucleosomal cleavage of genomic DNA is a biochemical hallmark of apoptosis. DNase gamma, a Mg2+/Ca2+-dependent endonuclease, has been suggested to be one of the apoptotic endonucleases, but its biochemical characteristic has not been fully elucidated. Here, using recombinant DNase gamma, we showed that DNase ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.04.107

    authors： Mizuta R,Mizuta M,Araki S,Shiokawa D,Tanuma S,Kitamura D

    更新日期：2006-06-30 00:00:00

  • The alternative translation of synaptotagmin 1 mediates the non-classical release of FGF1.

    abstract：:Although the extravesicular p40 domain of the transmembrane protein, p65 synaptotagmin (Syt) 1, is essential for the non-classical export of the signal peptide-less structure, FGF1, it was not possible to identify a specific intracellular protease responsible for the processing of p65 Syt1. Surprisingly, analysis of t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2003.09.119

    authors： Bagalá C,Kolev V,Mandinova A,Soldi R,Mouta C,Graziani I,Prudovsky I,Maciag T

    更新日期：2003-10-31 00:00:00

  • FAD oxidizes the ERO1-PDI electron transfer chain: the role of membrane integrity.

    abstract：:The molecular steps of the electron transfer in the endoplasmic reticulum from the secreted proteins during their oxidation are relatively unknown. We present here that flavine adenine dinucleotide (FAD) is a powerful oxidizer of the oxidoreductase system, Ero1 and PDI, besides the proteins of rat liver microsomes and...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.10.027

    authors： Papp E,Nardai G,Mandl J,Bánhegyi G,Csermely P

    更新日期：2005-12-16 00:00:00

  • GRK-6 mediates FSH action synergistically enhanced by estrogen and the oocyte in rat granulosa cells.

    abstract：:Estrogen is known to play a pivotal role in granulosa cell responses to follicle-stimulating hormone (FSH) that is critical for the establishment of dominant follicles and subsequent ovulation in mammals. Thus, elucidating the cellular and molecular mechanisms that regulate FSH activity is important to understand fema...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.04.002

    authors： Miyoshi T,Otsuka F,Shimasaki S

    更新日期：2013-05-03 00:00:00

  • TLR4 activates NF-κB in human ovarian granulosa tumor cells.

    abstract：:Previous studies have demonstrated expression of Toll-like receptors (TLRs) in the surface epithelium of normal ovaries (OSE) and in epithelial ovarian tumors. Most notably, OSE-derived cancers express TLR4, which activates the nuclear factor-kappa B (NF-κB) signaling cascade as a mediator of inflammatory response. Cu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.05.063

    authors： Woods DC,White YA,Dau C,Johnson AL

    更新日期：2011-06-17 00:00:00

  • The functional analysis of directed amino-acid alterations in ZntR from Escherichia coli.

    abstract：:The ZntR protein from Escherichia coli is a member of the MerR-family of transcriptional regulatory proteins and acts as a hyper-sensitive transcriptional switch primarily in response to Zn(II) and Cd(II). The binding of metal-ions to ZntR initiates a mechanism that remodels the cognate promoter, increasing its affini...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)02660-8

    authors： Khan S,Brocklehurst KR,Jones GW,Morby AP

    更新日期：2002-12-06 00:00:00

  • The mechanism of action of DuP 721, a new antibacterial agent: effects on macromolecular synthesis.

    abstract：:Pulse labeling studies with Bacillus subtilis showed that DuP 721 inhibited protein synthesis. The IC50 of DuP 721 for protein synthesis was 0.25 micrograms/ml but it was greater than 32 micrograms/ml for RNA and DNA synthesis. In cell-free systems, DuP 721 concentrations up to 100 microM did not inhibit peptide chain...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(88)90723-1

    authors： Eustice DC,Feldman PA,Slee AM

    更新日期：1988-02-15 00:00:00

  • Fission yeast LAMMER kinase Lkh1 regulates the cell cycle by phosphorylating the CDK-inhibitor Rum1.

    abstract：:In eukaryotes, LAMMER kinases are involved in various cellular events, including the cell cycle. However, no attempt has been made to investigate the mechanisms that underlie the involvement of LAMMER kinase. In this study, we performed a functional analysis of LAMMER kinase using the fission yeast, Schizosaccharomyce...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.01.082

    authors： Yu EY,Lee JH,Kang WH,Park YH,Kim L,Park HM

    更新日期：2013-03-01 00:00:00

  • Rapid delivery of small interfering RNA by biosurfactant MEL-A-containing liposomes.

    abstract：:The downregulation of gene expression by RNA interference holds great potential for genetic analysis and gene therapy. However, a more efficient delivery system for small interfering RNA (siRNA) into the target cells is required for wide fields such as cell biology, physiology, and clinical application. Non-viral vect...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.09.147

    authors： Inoh Y,Furuno T,Hirashima N,Kitamoto D,Nakanishi M

    更新日期：2011-10-28 00:00:00

  • Catalytic activity and stability of hammerhead ribozymes containing 2'-acetamido-2'-deoxyribonucleosides.

    abstract：:Hammerhead ribozymes may be of great therapeutic importance, since they can, in theory, be developed to cleave any undesired target RNA. In order to design ribozymes which are stable against endogenous RNases, we incorporated 2'-acetamido-2'-deoxynucleosides in the catalytic core of a hammerhead ribozyme. The 2'-aceta...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1628

    authors： Hendrix C,Mahieu M,Anné J,Van Calenbergh S,Van Aerschot A,Content J,Herdewijn P

    更新日期：1995-05-05 00:00:00

  • Binding specificity of Lactobacillus to glycolipids.

    abstract：:Lactobacillus, a representative useful bacterium, in the intestinal tract was found to bind to some specific glycosphingolipids, like the pathogenic intestinal bacteria. Thin layer chromatography overlay assays using rabbit antiserum against Lactobacillus casei revealed that the bacteria bound to GA1 and trihexosylcer...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.1630

    authors： Yamamoto K,Miwa T,Taniguchi H,Nagano T,Shimamura K,Tanaka T,Kumagai H

    更新日期：1996-11-01 00:00:00

  • Lyso(bis)phosphatidic acid: a novel source of arachidonic acid for oxidative metabolism by rabbit alveolar macrophages.

    abstract：:To identify the source of arachidonic acid utilized for eicosanoid production, rabbit alveolar macrophages were challenged with 1.0 microM 12-O-tetradecanoylphorbol-13-acetate (TPA) or 3.8 microM Ca+2 ionophore A23187 for 3 h. Upon stimulation with TPA, a loss of [3H]arachidonic acid from phosphatidylcholine, phosphat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)90487-5

    authors： Cochran FR,Connor JR,Roddick VL,Waite BM

    更新日期：1985-07-31 00:00:00

  • Proliferation of hematopoietic cells is accompanied by suppressed expression of heat shock protein 70.

    abstract：:In this study, we have examined the synthesis of heat shock protein (HSP70) in leukemia cells from acute myelogenous leukemia (AML) patients and in mononuclear cells from normal individuals, before and after growth factor stimulation. We have shown that the HSP70 protein was expressed in these cells in the absence of ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)90544-u

    authors： Zhang W,Drach J,Andreeff M,Deisseroth A

    更新日期：1992-03-16 00:00:00

  • Distribution and molecular forms of brain natriuretic peptide in porcine heart and blood.

    abstract：:Although brain natriuretic peptide (BNP) is a novel natriuretic peptide originally identified in porcine brain, recent investigation has verified the presence of BNP in porcine heart. In order to identify BNP as a circulating hormone, we analyzed the regional distribution and molecular form of immunoreactive (ir-) BNP...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(89)80047-6

    authors： Aburaya M,Minamino N,Kangawa K,Tanaka K,Matsuo H

    更新日期：1989-12-15 00:00:00

  • Promoter methylation regulates cadherin switching in squamous cell carcinoma.

    abstract：:Cadherins are cell adhesion molecules that modulate the epithelial phenotype and regulate tumor invasion. To identify the role of promoter methylation in regulating E-cadherin expression and in the "switching" of cadherins in oral squamous cell carcinoma (SCC), we studied 14 cell lines for cadherin expression. Immunob...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.01.143

    authors： Chen Q,Lipkina G,Song Q,Kramer RH

    更新日期：2004-03-19 00:00:00

  • A peptide mimetic of an anti-CD4 monoclonal antibody by rational design.

    abstract：:The development of rational methods to design 'continuous' sequence mimetics of discontinuous regions of protein sequence has, to now, been only marginally successful. This has been largely due to the difficulty of constraining the recognition elements of a mimetic structure to the relative conformational and spatial ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)01131-8

    authors： Casset F,Roux F,Mouchet P,Bes C,Chardes T,Granier C,Mani JC,Pugnière M,Laune D,Pau B,Kaczorek M,Lahana R,Rees A

    更新日期：2003-07-18 00:00:00

  • Lysophosphatidylserine stimulates chemotactic migration in U87 human glioma cells.

    abstract：:Lysophosphatidylserine (LPS) was found to stimulate intracellular calcium increase in U87 human glioma cells. LPS also stimulated chemotactic migration of U87 human glioma cells, which was completely inhibited by pertussis toxin (PTX). Moreover, LPS was also found to stimulate ERK, p38 MAPK, JNK, and Akt activities in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.06.117

    authors： Lee SY,Lee HY,Kim SD,Jo SH,Shim JW,Lee HJ,Yun J,Bae YS

    更新日期：2008-09-12 00:00:00