Destruxin B, a specific and readily reversible inhibitor of vacuolar-type H(+)-translocating ATPase.

abstract：:The influence of leucine starvation on the subcellular location of leucyl-tRNA synthetase in Escherichia coli was examined in a leucine auxotrophic strain by sucrose density sedimentation analysis. Analysis of the subcellular distribution of leucyl-tRNA synthetase activity revealed that during unrestricted growth, the...

journal_title：Biochemical and biophysical research communications

authors： Williamson RM

更新日期：1993-02-15 00:00:00

abstract：:Rhabdomyosarcomas (RMS) represent the most common childhood soft-tissue sarcoma. Over the past few decades outcomes for low and intermediate risk RMS patients have slowly improved while patients with metastatic or relapsed RMS still face a grim prognosis. New chemotherapeutic agents or combinations of chemotherapies h...

journal_title：Biochemical and biophysical research communications

authors： Kaylani SZ,Xu J,Srivastava RK,Kopelovich L,Pressey JG,Athar M

更新日期：2013-06-14 00:00:00

abstract：:Metallothionein (MT) is effective in the prevention of diabetic cardiomyopathy, and hypoxia-inducible factor-1 (HIF-1) is known to control vascular endothelial growth factor (VEGF) gene expression and regulate angiogenesis in diabetic hearts. We examined whether or not MT affects HIF-1 activity in the heart of diabeti...

journal_title：Biochemical and biophysical research communications

authors： Feng W,Wang Y,Cai L,Kang YJ

更新日期：2007-08-17 00:00:00

abstract：:We attempted to attenuate neointimal formation following vascular injury using a retroviral suicide vector. Epicardial coronary arteries of adult miniature swine were injured by deployment of oversized tantalum stents. One week later, injured segments were exposed to packaged retroviral constructs with or without the ...

journal_title：Biochemical and biophysical research communications

authors： Barbee RW,Stapleton DD,Madras DE,Ré RN,Murgo JP,Davenport WD,Giardina J,Cook JL

更新日期：1995-02-06 00:00:00

abstract：:3q21q26 syndrome, an acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) with chromosomal translocations or inversions between the bands 3q21 and 3q26, is frequently associated with dysmegakaryocytopoiesis and increased platelet counts at the initial diagnosis. Since the EVI1 gene at 3q26 is transcriptional...

journal_title：Biochemical and biophysical research communications

authors： Shimizu S,Nagasawa T,Katoh O,Komatsu N,Yokota J,Morishita K

更新日期：2002-04-05 00:00:00

abstract：:This study was designed to compare the temporal changes of gene expression profile in osteoblastic cell lines (SaOS-2) treated with low-intensity pulsed ultrasound stimulation (LIPUS) using complementary DNA (cDNA) microarrays. SaOS-2 cells were treated with LIPUS for 20min. Thereafter, cells were harvested and RNA wa...

journal_title：Biochemical and biophysical research communications

authors： Lu H,Qin L,Lee K,Cheung W,Chan K,Leung K

更新日期：2009-01-16 00:00:00

abstract：:Phosphorylation of membranes from murine erythroleukemia cells was performed in the presence and absence of the polar solvent dimethyl sulfoxide. Quantitation of the phosphoamino acid content revealed that DMSO stimulated phosphotyrosine accumulation by three-fold; serine and threonine phosphorylation decreased signif...

journal_title：Biochemical and biophysical research communications

authors： Earp HS,Rubin RA,Austin KS,Dy RC

更新日期：1983-04-29 00:00:00

abstract：:Anthrax-protective antigen is the central moiety of the anthrax toxin complex that mediates the entry of the other two toxin components, lethal factor and edema factor into the cells. It is also the main immunogen of the cell-free vaccine against anthrax. However, in addition to PA, the vaccine contains trace amounts ...

journal_title：Biochemical and biophysical research communications

authors： Ahuja N,Kumar P,Bhatnagar R

更新日期：2001-08-10 00:00:00

abstract：:Special AT-rich sequence-binding protein (SATB) plays a critical role in bone generation and osteoblast differentiation. In the present study, the differentially expressed genes by SATB2 overexpression were analyzed in MC3T3-E1 osteoblast-like cells using Alizarin red S staining, wound healing assay and Agilent's Huma...

journal_title：Biochemical and biophysical research communications

authors： Kim IS,Jeong SJ,Kim SH,Jung JH,Park YG,Kim SH

更新日期：2012-01-13 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Biochemical and biophysical research communications

authors： Jiang J,Liu Y,Tang Y,Li L,Zeng R,Zeng S,Zhong M

更新日期：2016-12-03 00:00:00

abstract：:Receptor tyrosine kinase EphA7 is specifically expressed in otic region in Xenopus early development. However, its role in otocyst development remains unknown. Knockdown of EphA7 by a specific morpholino oligonucleotide (MO) reduced the size of the otocyst and triggered otic epithelial cell extrusion. Interestingly, E...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Sun J,Wang Z,Li C,Mao B

更新日期：2020-05-28 00:00:00

abstract：:Ischemic injury is a primary contributor to the initiation of renal tubular epithelial cell damage in sickle cell disease (SCD). In this study, we investigated the effects of bilateral ischemia-reperfusion injury, which is a common type of acute kidney injury (AKI), in male and female genetic mouse model of SCD. Bilat...

journal_title：Biochemical and biophysical research communications

authors： Park F,Soni H,Pressly JD,Adebiyi A

更新日期：2019-07-12 00:00:00

abstract：:Transgenic animals were used to examine the spatial and temporal regulation of the human beta amyloid precursor protein (APP) gene promoter region in vivo. A 2.9 kb DNA fragment encompassing the APP gene promoter was fused to the chloramphenical acetyltransferase (CAT) reporter gene (pAMY-CAT) or a partial cDNA encodi...

journal_title：Biochemical and biophysical research communications

authors： Fox NW,Johnstone EM,Ward KE,Schrementi J,Little SP

更新日期：1997-11-26 00:00:00

abstract：:Pulmonary fibrosis is a progressive disorder whose molecular pathology is poorly understood. Here we developed an in-house cDNA microarray ("lung chip") originating from a lung-normalized cDNA library. By using this lung chip, we analyzed global gene expression in a murine model of bleomycin-induced fibrosis and selec...

journal_title：Biochemical and biophysical research communications

authors： Katsuma S,Nishi K,Tanigawara K,Ikawa H,Shiojima S,Takagaki K,Kaminishi Y,Suzuki Y,Hirasawa A,Ohgi T,Yano J,Murakami Y,Tsujimoto G

更新日期：2001-11-09 00:00:00

abstract：:Kinase suppressor of ras (KSR) and MEKK3 (MAP kinase kinase kinase) are integral members of the MAP kinase pathway. We have recently identified a new isoform of the KSR family named human kinase suppressor of ras-2 (hKSR-2), and demonstrated that hKSR-2 negatively regulates Cot, a MAP3K family member which is importan...

journal_title：Biochemical and biophysical research communications

authors： Channavajhala PL,Rao VR,Spaulding V,Lin LL,Zhang YG

更新日期：2005-09-09 00:00:00

abstract：:We have characterized genomic structure and transcription of a murine odorant receptor (OR) gene, MOR23. This gene has two distinct transcriptional initiation regions, which are differentially utilized in the olfactory and testicular cells. We have found that the MOR23 gene has an intron within the 5'-untranslated reg...

journal_title：Biochemical and biophysical research communications

authors： Asai H,Kasai H,Matsuda Y,Yamazaki N,Nagawa F,Sakano H,Tsuboi A

更新日期：1996-04-16 00:00:00

abstract：:Dark-operative protochlorophyllide (Pchlide) oxidoreductase (DPOR) is a nitrogenase-like enzyme catalyzing a reduction of the C17 = C18 double bond of Pchlide to form chlorophyllide a (Chlide) in bacteriochlorophyll biosynthesis. DPOR consists of an ATP-dependent reductase component, L-protein (a BchL dimer), and a ca...

journal_title：Biochemical and biophysical research communications

authors： Nomata J,Terauchi K,Fujita Y

更新日期：2016-02-12 00:00:00

abstract：:The human gene Teratocarcinoma-derived growth factor 1 (TDGF1)/Cripto-1/CR-1 which is expressed in a wide variety of human carcinomas is a member of the EGF-cripto FRL1 cryptic (EGF-CFC) gene family. A majority of human colorectal tumors and hepatomas are known to possess a constitutively active canonical Wnt/beta-cat...

journal_title：Biochemical and biophysical research communications

authors： Hamada S,Watanabe K,Hirota M,Bianco C,Strizzi L,Mancino M,Gonzales M,Salomon DS

更新日期：2007-03-30 00:00:00

abstract：:Progesterone (Pg) is an essential steroid hormone during mammary gland development and tumorigenesis, including the maintenance of epithelial stem/progenitor cells. Pg functions through interaction with the progesterone receptors (PR) and Pg-PR signaling is thought to be mediated by key transcription factors, which ar...

journal_title：Biochemical and biophysical research communications

authors： Li M,Zhao D,Ma G,Zhang B,Fu X,Zhu Z,Fu L,Sun X,Dong JT

更新日期：2013-01-04 00:00:00

abstract：:Long repeated stretches of d(CCG) and tri-nucleotide are crucial mutations that cause hereditary forms of mental retardation (fragile X-syndrome). Moreover, the alternating (CG) di-nucleotide is one of the candidates for Z-DNA conformation. Solution NMR structure of d(CCGCGG)(2) has been solved and is discussed. The d...

journal_title：Biochemical and biophysical research communications

authors： Monleón D,Esteve V,Celda B

更新日期：2003-03-28 00:00:00

abstract：:In this paper we describe for the first time the inhibitory effect of three amphiphilic cations, trifluoperazine, propranolol and dibucaine on mitochondrial protein import. The amphiphilic cations did not affect binding of mitochondrial precursor proteins to mitochondria. Import into mitoplasts was affected in a simil...

journal_title：Biochemical and biophysical research communications

authors： Pavlov PF,Glaser E

更新日期：1998-11-09 00:00:00

abstract：:Spinal muscular atrophy (SMA) is caused by mutations within the survival motor neuron 1 (SMN1) gene. These mutations result in the reduction of survival motor neuron (SMN) protein expression and SMN complex in spinal motor neurons and other tissues. SMN protein has been used as a therapeutic biomarker in recent SMA cl...

journal_title：Biochemical and biophysical research communications

authors： Arakawa M,Arakawa R,Tatsumi S,Aoki R,Saito K,Nomoto A

更新日期：2014-10-24 00:00:00

abstract：:Addition of 5% hexadecane to the diet of rats increased fecal excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) from 14 to 39% of an LD50 dose (60 micrograms/kg) during 10 days after dosing. This enhanced elimination did not result in reduced toxicity. On the contrary, the treatment has increased mortality from ...

journal_title：Biochemical and biophysical research communications

authors： Rozman K

更新日期：1984-12-28 00:00:00

abstract：:A novel hemoglobin variant was detected by electrospray ionization mass spectrometry. Hb Zurich-Hottingen is characterized by an Asn --> Ser replacement in the alpha-chain at position 9 as confirmed by DNA analysis. This hemoglobin variant is silent in isoelectric focusing, reversed-phase chromatography, and cation-ex...

journal_title：Biochemical and biophysical research communications

authors： Troxler H,Neuheiser F,Kleinert P,Kuster T,Heizmann CW,Sack R,Hunziker P,Neuhaus TJ,Schmid M,Frischknecht H

更新日期：2002-04-12 00:00:00

abstract：:Chloroquine (CQ) and amodiaquine (AQ) have been used for treating or preventing malaria for decades, and their application has expanded into treating inflammatory disease in humans. CQ and AQ are applicable for controlling rheumatoid arthritis, but their molecular mechanisms of anti-inflammatory activity remain to be ...

journal_title：Biochemical and biophysical research communications

authors： Oh S,Shin JH,Jang EJ,Won HY,Kim HK,Jeong MG,Kim KS,Hwang ES

更新日期：2016-05-27 00:00:00

abstract：:A polyclonal antibody against a MAP kinase (DdERK2) in Dictyostelium has been made and used to study DdERK2 activation and localization. The activation of DdERK2 by the chemoattractants cAMP and folate is rapid and transient. Its activity peaks between 15 and 60 seconds after cAMP stimulation and declines to basal lev...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Segall JE

更新日期：1998-03-06 00:00:00

abstract：:An inhibitor against the egg beta-D-N-acetylglucosaminidase (GlcNAcase) was purified from the vitelline coat of eggs of the ascidian, Halocynthia roretzi. The purified inhibitor gave a single band with an apparent molecular mass of 70 kDa on SDS-PAGE under non-reducing conditions. The GlcNAcase inhibitor potently inhi...

journal_title：Biochemical and biophysical research communications

authors： Matsuura K,Sawada H,Yokosawa H

更新日期：1995-08-04 00:00:00

abstract：:Sirt1 appear to be NAD(+)-dependent deacetylase that deacetylates histones and several non-histone proteins. In this study, we identified Sirt1 as a physical interaction partner of Tip60, which is a mammalian MYST-type histone acetyl-transferase that specifically acetylates histones H2A and H4. Although Tip60 also ace...

journal_title：Biochemical and biophysical research communications

authors： Yamagata K,Kitabayashi I

更新日期：2009-12-25 00:00:00

abstract：:Within 4 h following the addition of 3,3',5 triiodo-L-thyronine to monolayer cultures of hepatocytes isolated from hypothyroid rats, a very distinct stimulation of fatty acid and cholesterol synthesis, measured as incorporation of either [1-14C]acetate or [3H]H2O into these lipid fractions, is observed. A smaller but ...

journal_title：Biochemical and biophysical research communications

authors： Gnoni GV,Geelen MJ,Bijleveld C,Quagliariello E,van den Bergh SG

更新日期：1985-04-30 00:00:00

abstract：:Hereditary multiple exostoses (EXT) is an autosomal dominant disorder that is characterized by the appearance of multiple outgrowths of the long bones (exostoses) at their epiphyses. Genetical heterogeneities have segregated at least on chromosome 8, 11, and 19 and been designated EXT1, EXT2, and EXT3, respectively. R...

journal_title：Biochemical and biophysical research communications

authors： Saito T,Seki N,Yamauchi M,Tsuji S,Hayashi A,Kozuma S,Hori T

更新日期：1998-02-04 00:00:00