Molecular monitoring of bleomycin-induced pulmonary fibrosis by cDNA microarray-based gene expression profiling.

abstract：:Cytochrome P-450 LMeb was purified from liver microsomes obtained from rabbits treated with either benzene or imidazole and was shown to have identical N-terminal amino acid sequence as that of cytochrome P-450 LM3a. The amino acid compositions of the proteins were indistinguishable. Quantitation of P-450 LMeb in vari...

journal_title：Biochemical and biophysical research communications

authors： Ingelman-Sundberg M,Jörnvall H

更新日期：1984-10-30 00:00:00

abstract：:The vibrational frequency of CO bound to myoglobin can be varied by up to 60 cm-1 by making site-specific mutations in the distal pocket. These changes may result from specific chemical interactions between distal amino acids and the CO or from changes in the electrostatic field of the distal pocket. In this paper, we...

journal_title：Biochemical and biophysical research communications

authors： Decatur SM,Boxer SG

更新日期：1995-07-06 00:00:00

abstract：:Inhibitors of phenoloxidase were identified in pupae of the housefly, Musca domestica L. The phenoloxidase inhibitors were purified from final instar pupae of the housefly by a combination of ammonium sulfate fractionation, ion-exchange chromatography, gel filtration and reverse-phase high performance liquid chromatog...

journal_title：Biochemical and biophysical research communications

authors： Tsukamoto T,Ichimaru Y,Kanegae N,Watanabe K,Yamaura I,Katsura Y,Funatsu M

更新日期：1992-04-15 00:00:00

abstract：:We screened various isoprenoids to search for inducers of apoptosis-like cell death ("apoptosis") in the shoot primordia of Matricaria chamomilla and found that geraniol has the most potent apoptosis-inducing activity among terpenoids, as judged from DNA fragmentation in the cells. The apoptosis-inducing activity of g...

journal_title：Biochemical and biophysical research communications

authors： Izumi S,Takashima O,Hirata T

更新日期：1999-06-16 00:00:00

abstract：:We have previously shown that estrogen effects in the heart include direct hormone effects on the myocardium. In a recent study we found that one beneficial effect of estradiol on the myocardium is the inhibition of apoptosis in cardiac myocytes. This effect was associated with a reduction of NF-kappaB activity. In th...

journal_title：Biochemical and biophysical research communications

authors： Pelzer T,Neumann M,de Jager T,Jazbutyte V,Neyses L

更新日期：2001-09-07 00:00:00

abstract：:The gene III protein (pIII) from phi Lf, a filamentous phage of Xanthomonas campestris pv.campestris, was purified by gel filtration with FPLC. The gIII coding region was amplified by PCR, which was then cloned into pUC18 and expressed in Escherichia coli. The size of both pIII, purified from phage particle and expres...

journal_title：Biochemical and biophysical research communications

authors： Liu TJ,You BY,Lin NT,Yang MT,Tseng YH

更新日期：1998-01-06 00:00:00

abstract：:Previous studies suggested that the hydrophobic protein chargerin II, which is encoded in the A6L of mitochondrial DNA, may have a key role in the energy transduction by mitochondrial H(+)-ATP synthase because an antibody against chargerin II inhibited ATP synthesis and ATP-Pi exchange, in an energy-dependent fashion....

journal_title：Biochemical and biophysical research communications

authors： Muraguchi M,Yoshihara Y,Tunemitu T,Tani I,Higuti T

更新日期：1990-04-16 00:00:00

abstract：:Atrazine is a widely used triazine herbicide. Although controversy still exists, a number of recent studies have described its adverse effects on various animals including humans. Of particular interest is its effects on reproductive capacity. In this study, we investigated the mechanisms underlying the adverse effect...

journal_title：Biochemical and biophysical research communications

authors： Hase Y,Tatsuno M,Nishi T,Kataoka K,Kabe Y,Yamaguchi Y,Ozawa N,Natori M,Handa H,Watanabe H

更新日期：2008-02-01 00:00:00

abstract：:Ultrasound (US) has emerged as a promising noninvasive modality for neuromodulation. Despite previous evidence that US may mediate cellular response by activating mechanosensitive ion channels embedded in the cell membrane, the underlying mechanism is not well understood. In this work, we developed a vertically deploy...

journal_title：Biochemical and biophysical research communications

authors： Liao D,Li F,Lu D,Zhong P

更新日期：2019-10-20 00:00:00

abstract：:It has been suggested that epigenetic regulation plays an important role in maintaining the stemness and lineage differentiation of hematopoietic stem cells (HSCs), 5-aza-deoxycytidine (aza-D) and Trichostatin A (TSA) being candidate additives for HSC ex vivo expansion. Although they have potent activity to maintain t...

journal_title：Biochemical and biophysical research communications

authors： Koh SH,Choi HS,Park ES,Kang HJ,Ahn HS,Shin HY

更新日期：2005-04-15 00:00:00

abstract：:Our laboratory demonstrated that endoplasmic reticulum iPLA2 (ER-iPLA2) activity protects renal cells from oxidant-induced cell death and lipid peroxidation. The goals of this study were to determine the PLA2 isoform(s) responsible for ER-iPLA2 activity in different species and tissues. ER-iPLA2 activity was observed ...

journal_title：Biochemical and biophysical research communications

authors： Kinsey GR,Cummings BS,Beckett CS,Saavedra G,Zhang W,McHowat J,Schnellmann RG

更新日期：2005-02-04 00:00:00

abstract：:Two fractions with high potency for reversing the inhibitory effect of Met-enkephalin on the electrically induced contractility of guinea-pig ileum have been purified from bovine brain extract. Unexpectedly, one isolated peptide was identified as [Val5]-angiotensin I and the other fraction was [Val5]-angiotensin II, a...

journal_title：Biochemical and biophysical research communications

authors： Kaneko S,Tamura S,Takagi H

更新日期：1985-01-16 00:00:00

abstract：:Different progestogens are widely used in hormonal therapy and mediate their therapeutic actions via the progesterone receptor (PR). Little published data exist on their relative efficacies and potencies via the PR, while those available may be confounded by off-target receptors, different methodologies and model syst...

journal_title：Biochemical and biophysical research communications

authors： Enfield K,Cartwright M,Toit RL,Avenant C,Africander D,Hapgood JP

更新日期：2020-12-17 00:00:00

abstract：:Angiogenesis is a core hallmark of advanced cancers, especially in lung adenocarcinoma (LUAD). However, the underlying functions and mechanisms of lncRNAs in tumor angiogenesis remain largely unknown. Here we found that linc00665 depletion could markedly depressed proliferation and capillary tube formation of HUVECs i...

journal_title：Biochemical and biophysical research communications

authors： Cong Z,Diao Y,Li X,Jiang Z,Xu Y,Zhou H,Qiang Y,Wu H,Shen Y

更新日期：2020-06-25 00:00:00

abstract：:The potential antiatherogenic actions of the angiotensin II receptor antagonist, losartan were investigated in apolipoprotein (apo) E deficient mice, an animal model with severe hypercholesterolemia and extensive atherosclerosis. In these animals accelerated atherosclerosis is associated with increased lipid peroxidat...

journal_title：Biochemical and biophysical research communications

authors： Keidar S,Attias J,Smith J,Breslow JL,Hayek T

更新日期：1997-07-30 00:00:00

abstract：:The major form of cytochrome P-450, P-450K-5, was purified from kidney microsomes of untreated male rats with high-performance liquid chromatography with anion-exchange and hydroxylapatite columns. The monomeric molecular weight of P-450K-5 was 52000 on SDS-polyacrylamide gel electrophoresis and the CO-reduced absorpt...

journal_title：Biochemical and biophysical research communications

authors： Imaoka S,Funae Y

更新日期：1986-12-15 00:00:00

abstract：:Hepatitis B virus (HBV) is a small virus that infects the liver. The major obstacle in applying the RNA interference method as an anti-HBV weapon is the challenge to deliver the small interfering RNA molecules to the liver efficiently and specifically. Here we show that HBV-specific short hairpin RNAs (shRNAs) are eff...

journal_title：Biochemical and biophysical research communications

authors： Shlomai A,Lubelsky Y,Har-Noy O,Shaul Y

更新日期：2009-12-18 00:00:00

abstract：:Using an anti-serum against synthetic alpha-inhibin-31, we have studied its cellular locations in rodent testis and brain. Western blot analysis detected several molecular forms of the protein(s). A protein of 17 KDa in size was detected in testis of one month old mice. Two major bands of molecular weights 39 kDA and ...

journal_title：Biochemical and biophysical research communications

authors： Lau YF,Li CH

更新日期：1987-05-29 00:00:00

abstract：:The alpha-ketoglutarate dehydrogenase complex of Escherichia coli can bind up to 12 dimers of dihydrolipoyl dehydrogenase (E3) besides those already present. Maximal activity does not increase, however, when surplus E3 is present. This observation was previously interpreted to mean that the excess enzyme is inactive. ...

journal_title：Biochemical and biophysical research communications

authors： Wagenknecht T,Francis N,DeRosier D

更新日期：1986-03-28 00:00:00

abstract：:Monodisperse bovine prothrombin was prepared and its molecular states under several conditions examined. The protein showed no tendency to self-associate in the absence of calcium. Calcium (4 mM) caused small increases in the apparent molecular weight of the protein which may or may not represent protein dimerization ...

journal_title：Biochemical and biophysical research communications

authors： Silversmith RE,Wei GJ,Nelsestuen GL

更新日期：1983-02-28 00:00:00

abstract：:In RBL-2H3 rat basophilic leukemia cells, Fc epsilon R1 crosslinking by multivalent antigen stimulates phosphatidylinositol (PI) turnover and Ca2+ influx and causes functional responses that include secretion, membrane ruffling and actin polymerization. Here, we show that the tyrosine kinase inhibitor, genistein, inhi...

journal_title：Biochemical and biophysical research communications

authors： Deanin GG,Martinez AM,Pfeiffer JR,Gardner ME,Oliver JM

更新日期：1991-08-30 00:00:00

abstract：:A murine genomic clone of about 16 kilobases encompassing putatively entire bone morphogenetic protein (BMP)-4 gene has been isolated. Comparison with the cDNA clones revealed the existence of at least five exons on the 3' side of the clone. There are two alternative transcriptional start sites, one is for the first e...

journal_title：Biochemical and biophysical research communications

authors： Kurihara T,Kitamura K,Takaoka K,Nakazato H

更新日期：1993-05-14 00:00:00

abstract：:In this study, we devised a simple and rapid method to analyze fidelity of reverse transcriptase (RT) using next-generation sequencing (NGS). The method comprises a cDNA synthesis reaction from standard RNA with a primer containing a tag of 14 randomized bases and the RT to be tested, PCR using high-fidelity DNA polym...

journal_title：Biochemical and biophysical research communications

authors： Yasukawa K,Iida K,Okano H,Hidese R,Baba M,Yanagihara I,Kojima K,Takita T,Fujiwara S

更新日期：2017-10-14 00:00:00

abstract：:PES1 (also known as Pescadillo), a nucleolar protein, was involved in biogenesis of ribosomal RNA. Up-regulation of PES1 has been documented in some human cancers, indicating that PES1 may play some crucial roles in tumorigenesis. In our previous study, it was found that silencing of PES1 resulted in decreased prolife...

journal_title：Biochemical and biophysical research communications

authors： Xie W,Qu L,Meng L,Liu C,Wu J,Shou C

更新日期：2013-02-15 00:00:00

abstract：:We previously found that p53 binds to the catalytic subunit of the p34(cdc2)/cyclin B1-kinase. In the present study we analyzed the functional consequences of this interaction. Binding of wild-type p53 to p34(cdc2)/cyclin B1 results in a significant decrease of its histone H1 kinase activity. Binding of p53 to the kin...

journal_title：Biochemical and biophysical research communications

authors： Ababneh M,Götz C,Montenarh M

更新日期：2001-05-04 00:00:00

abstract：:The influence of leucine starvation on the subcellular location of leucyl-tRNA synthetase in Escherichia coli was examined in a leucine auxotrophic strain by sucrose density sedimentation analysis. Analysis of the subcellular distribution of leucyl-tRNA synthetase activity revealed that during unrestricted growth, the...

journal_title：Biochemical and biophysical research communications

authors： Williamson RM

更新日期：1993-02-15 00:00:00

abstract：:Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictor peptide with potent pressor activity. We studied the effect of ET-1 on release of arginine-vasopressin (AVP) from perifused rat hypothalamus. ET-1 (10(-10) to 10(-8) M) significantly stimulated AVP release. The ET-1-induced AVP release was completely blocke...

journal_title：Biochemical and biophysical research communications

authors： Shichiri M,Hirata Y,Kanno K,Ohta K,Emori T,Marumo F

更新日期：1989-09-29 00:00:00

abstract：:This article has been withdrawn at the request of the editors. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Biochemical and biophysical research communications

authors： Achour M,Mousli M,Alhosin M,Ibrahim A,Peluso J,Muller CD,Schini-Kerth VB,Hamiche A,Dhe-Paganon S,Christian Bronner

更新日期：2012-07-04 00:00:00

abstract：:Chronic kidney disease (CKD) is strongly associated with increased cardiovascular risk. Impaired endothelial function, a key initiating step in the pathogenesis of cardiovascular disease, has been reported in patients with CKD, but the mechanisms responsible for endothelial dysfunction in CKD remain elusive. Emerging ...

journal_title：Biochemical and biophysical research communications

authors： Li T,Gua C,Wu B,Chen Y

更新日期：2018-01-08 00:00:00

abstract：:Junctional membrane complexes (JMCs) generated by junctophilins are required for Ca(2+)-mediated communication between cell-surface and intracellular channels in excitable cells. Knockout mice lacking neural junctophilins (JP-DKO) show severe motor defects and irregular cerebellar plasticity due to abolished channel c...

journal_title：Biochemical and biophysical research communications

authors： Ikeda A,Miyazaki T,Kakizawa S,Okuno Y,Tsuchiya S,Myomoto A,Saito SY,Yamamoto T,Yamazaki T,Iino M,Tsujimoto G,Watanabe M,Takeshima H

更新日期：2007-11-23 00:00:00