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Murine bone morphogenetic protein-4 gene: existence of multiple promoters and exons for the 5'-untranslated region.

Abstract：

:A murine genomic clone of about 16 kilobases encompassing putatively entire bone morphogenetic protein (BMP)-4 gene has been isolated. Comparison with the cDNA clones revealed the existence of at least five exons on the 3' side of the clone. There are two alternative transcriptional start sites, one is for the first exon the other for the second, the resulting exon organization in mRNA is I-III-IV-V and II-III-IV-V, respectively. The coding region is dispersed between exons IV and V. Both promoter regions carry no canonical TATA box but carry GC rich sequences.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kurihara T,Kitamura K,Takaoka K,Nakazato H

doi

10.1006/bbrc.1993.1523

subject

Has Abstract

pub_date

1993-05-14 00:00:00

pages

1049-56

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)71523-8

journal_volume

192

pub_type

杂志文章

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