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Direct evidence for expression of type II flavoprotein subunit in human complex II (succinate-ubiquinone reductase).

Abstract：

:Succinate-ubiquinone reductase (complex II) is an important enzyme complex in aerobic respiration and the tricarboxylic acid cycle. We recently identified two distinct cDNAs for the human flavoprotein subunit (Fp) from a single individual and demonstrated mRNAs of these two isoforms, Type I Fp and Type II Fp, in skeletal muscle, liver, brain, heart, and kidney. Type I Fp was expressed at higher levels than Type II Fp in all cases. In the present study, the biochemical properties of Type II Fp-containing complex II in Raji cells predominantly expressing Type II Fp were investigated. Complex II having Type II Fp was separated from that having Type I Fp by isoelectric focusing in the presence of sucrose monolaurate. Together with the fact that succinate-ubiquinone reductase activity of mitochondria prepared from Raji cell was almost identical to that from human liver, these results clearly indicate the presence of two distinct isoforms of active complex II in human mitochondria.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tomitsuka E,Goto Y,Taniwaki M,Kita K

doi

10.1016/j.bbrc.2003.10.065

subject

Has Abstract

pub_date

2003-11-21 00:00:00

pages

774-9

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X03021648

journal_volume

311

pub_type

杂志文章

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