Abstract:
:Contraction of rat uterine smooth muscle related to phosphorylation state of myosin light chain under various conditions was investigated. In the Ca2(+)-containing medium, both high K+ and oxytocin induced marked contraction of the muscle accompanied by pronounced phosphorylation of myosin light chain. In the Ca2(+)-free medium, although both vanadate and oxytocin induced slight contraction, phosphorylation of myosin light chain was only evident for vanadate but not for oxytocin. It was suggested that another mechanism distinct from myosin light chain phosphorylation might be involved in Ca2(+)-independent contraction of uterine smooth muscle elicited by oxytocin.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Oishi K,Takano-Ohmuro H,Minakawa-Matsuo N,Suga O,Karibe H,Kohama K,Uchida MKdoi
10.1016/0006-291x(91)90898-hsubject
Has Abstractpub_date
1991-04-15 00:00:00pages
122-8issue
1eissn
0006-291Xissn
1090-2104pii
0006-291X(91)90898-Hjournal_volume
176pub_type
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