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Both stimulatory and inhibitory GDP/GTP exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins.

Abstract：

:Six peaks of small GTP-binding proteins (G proteins) were separated by column chromatographies from the cytosol fraction of the differentiated HL-60 cells: two peaks of rho p21, one peak of smg/rap1 p21, two peaks of rac1 p21, and one peak of an unidentified small G protein with a Mr of about 20,000 (20 KG). smg GDS, previously thought to be a stimulatory GDP/GTP exchange protein for smg p21, Ki-ras p21, and rho p21, but not for Ha-ras p21 or smg p25A, was also active on rac1 p21. rho GDI, previously thought to be an inhibitory GDP/GTP exchange protein specific for rho p21, was also active on rac1 p21. These results indicate that both smg GDS and rho GDI are active on multiple small G proteins.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hiraoka K,Kaibuchi K,Ando S,Musha T,Takaishi K,Mizuno T,Asada M,Ménard L,Tomhave E,Didsbury J

doi

10.1016/0006-291x(92)91820-g

subject

Has Abstract,Author List Incomplete

pub_date

1992-01-31 00:00:00

pages

921-30

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(92)91820-G

journal_volume

182

pub_type

杂志文章

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