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RhoA inactivation is crucial to manganese-induced astrocyte stellation.

Abstract：

:Actin depolymerization through Rho GTPases or exogenous mechanical tension has been suggested as a key determinant for the formation of astrocyte stellation. Rho GTPases function as switching molecules to converge both extracellular and intracellular signals in regulation of cytoskeletal organization. Their involvement in manganese-induced astrocyte stellation was assessed. The disruption of cytoskeletal architecture by manganese indicated the decreased activity of RhoA. Pharmacological and biochemical approaches revealed the inactivation of RhoA by manganese. This inactivation was partly through the down-regulation of guanine nucleotide exchange factor phosphorylation. Furthermore, the dephosphorylation of myosin light chain and cofilin through the inactivated RhoA effectors synergistically destabilized actin stress fibers. We conclude that manganese regulates cytoskeletal organization in astrocytes by modulating the activity of p115RhoGEF and RhoA.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Chen CJ,Liao SL,Huang YS,Chiang AN

doi

10.1016/j.bbrc.2004.11.121

subject

Has Abstract

pub_date

2005-01-28 00:00:00

pages

873-9

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(04)02717-2

journal_volume

326

pub_type

杂志文章

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