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The protective effect of orally administered redox nanoparticle on intestinal ischemia-reperfusion injury in mice.

Abstract：

BACKGROUND:Intestinal ischemia-reperfusion (I-R) injury is a serious abdominal condition leading to multiple organ failure with high mortality. However, no reliable treatment is available. A redox nanoparticle (RNPO) was recently developed, and its efficacy for several intestinal inflammatory conditions has been reported. To this end, the aim of this study was to investigate the therapeutic effects of RNPO on intestinal I-R injury in mice. METHODS:Ischemia was induced in the small intestine of C57BL/6 mice by occluding the superior mesenteric artery for 45 min under anesthesia followed by reperfusion for 4 h. Mice were orally administered the vehicle or RNPO 1 h before ischemia. Inflammatory markers such as histological findings, thiobarbituric acid (TBA)-reactive substances as an index of lipid peroxidation, myeloperoxidase (MPO) activity as an index of neutrophil infiltration, and expression of pro-inflammatory cytokine mRNA in the intestinal mucosa were assessed. RESULTS:Induction of I-R caused a significant increase in inflammatory markers (histological scores, TBA-reactive substances, MPO activity, and expression of keratinocyte chemoattractant mRNA). These changes were significantly attenuated in RNPO-treated mice as compared to vehicle-treated mice. CONCLUSION:Orally administered RNPO attenuated intestinal I-R injury in mice in association with reductions in neutrophil infiltration and lipid peroxidation, suggesting the possibly potential of RNPO as a therapeutic agent for intestinal I-R injury.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ueda T,Takagi T,Katada K,Iida T,Mizushima K,Dohi O,Okayama T,Yoshida N,Kamada K,Uchiyama K,Handa O,Ishikawa T,Konishi H,Naito Y,Nagasaki Y,Itoh Y

doi

10.1016/j.bbrc.2017.11.204

subject

Has Abstract

pub_date

2018-01-08 00:00:00

pages

2044-2049

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(17)32381-1

journal_volume

495

pub_type

杂志文章

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