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An inhibitory protein of intestinal fluid secretion reverses neuronal GABA transport.

Abstract：

:Intestinal challenge with cholera toxin induces the synthesis of a hormone-like protein which counteracts intestinal hypersecretion. This study shows that the protein also inhibits GABA transport across the plasma membrane of Deiters' cells in rabbits. The inhibitory action of the protein was dose dependent, and 10(3) times more potent than met 5-enkephalin, hitherto the most effective known inhibitor of GABA transport in vitro. The influence of the protein on the plasma membrane was reversible, and did not affect either postsynaptic binding or uptake of GABA.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lange S,Lönnroth I,Palm A,Hydén H

doi

10.1016/0006-291x(85)91719-x

subject

Has Abstract

pub_date

1985-08-15 00:00:00

pages

1032-6

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(85)91719-X

journal_volume

130

pub_type

杂志文章

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