Adenosine acts as an endogenous activator of the cellular antioxidant defense system.

abstract：:Reactive oxygen species (ROS) are an important factor in the development of skin lesions in diabetes. A new antioxidant, hydrogen, can selectively neutralize hydroxyl radicals (()OH) and peroxynitrite (ONOO(-)) in cell-free systems, whereas it seldom reacts with other ROS. Fibroblasts are a key component of skin. In t...

journal_title：Biochemical and biophysical research communications

authors： Yu P,Wang Z,Sun X,Chen X,Zeng S,Chen L,Li S

更新日期：2011-06-03 00:00:00

abstract：:Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that is known to reduce hepatic low-density lipoprotein receptor (LDLR) levels and increase plasma LDL cholesterol. It is not clear, however, whether secreted PCSK9 degrades extrahepatic LDLRs. We present evidence that recombinant PCSK9, either...

journal_title：Biochemical and biophysical research communications

authors： Schmidt RJ,Beyer TP,Bensch WR,Qian YW,Lin A,Kowala M,Alborn WE,Konrad RJ,Cao G

更新日期：2008-06-13 00:00:00

abstract：:E Prostanoid (EP) receptors play an important role in urinary Na(+) excretion. In the kidney, the epithelial sodium channel (ENaC) is the rate-limiting-step for Na(+) reabsorption. We hypothesized that activation of EP1/EP3 regulates the expression of ENaC in the face of renin-angiotensin-aldosterone-system (RAAS) act...

journal_title：Biochemical and biophysical research communications

authors： González AA,Céspedes C,Villanueva S,Michea L,Vio CP

更新日期：2009-11-13 00:00:00

abstract：:The human promyelocytic leukemia cell line HL-60 can be differentiated to cells resembling either neutrophils or mononuclear phagocytes by a diverse group of stimuli. However, the underlying mechanisms remain unknown. We report that 1-0-hexadecyl-2-acetyl-sn-glycerol inhibits the growth of HL-60 cells and induces diff...

journal_title：Biochemical and biophysical research communications

authors： McNamara MJ,Schmitt JD,Wykle RL,Daniel LW

更新日期：1984-07-31 00:00:00

abstract：:Extracellular calcium addition transiently stimulated two S6 peptide kinase activities in isolated rat hepatocytes. Mono Q chromatography revealed that the activities eluting at 0.15 M NaCl and 0.18 M NaCl were stimulated 4-fold and 2-fold, respectively. The kinase stimulated by calcium was a 40000-Mr S6 peptide kinas...

journal_title：Biochemical and biophysical research communications

authors： Harlin JC,Tredano M,Rider MH,Bollen M,Chédeville A,Lavoinne A

更新日期：1997-10-20 00:00:00

abstract：:HIV-1 Vpr is a protein with multiple functions. It has been suggested that such pleiotropic effects by a viral protein may be mediated by its association with viral and cellular proteins or through modulation of expression of specific cellular genes. To address this, we used cDNA microarray techniques to analyze the r...

journal_title：Biochemical and biophysical research communications

authors： Janket ML,Manickam P,Majumder B,Thotala D,Wagner M,Schafer EA,Collman RG,Srinivasan A,Ayyavoo V

更新日期：2004-02-20 00:00:00

abstract：:Microglia are central nervous system-resident immune cells that play a crucial role in brain development by interacting with neural precursor cells (NPCs). It has been reported that microglia regulate the number of NPC by phagocytosis, inducing apoptosis, and promoting proliferation. Microglia surrounding the subventr...

journal_title：Biochemical and biophysical research communications

authors： Yamamiya M,Tanabe S,Muramatsu R

更新日期：2019-06-11 00:00:00

abstract：:The physical and catalytic properties of 5 histidine-serine mutants of human 5-lipoxygenase (5-LO) have been characterized. The mutants HS363, HS391 and HS400 have activities, pH optima and stabilities similar to those of the wild type enzyme. The iron content of each of these mutants is 0.30-0.53 mol Fe/mol 5-LO whic...

journal_title：Biochemical and biophysical research communications

authors： Percival MD,Ouellet M

更新日期：1992-08-14 00:00:00

abstract：:We show here that the susceptibility of endothelial cells to Shiga toxin (Stx)s differs remarkably depending on their cellular origins. The concentration of Stx-1 required to reduce cell viability by 50% as measured by MTT assay was 30 and 300 fM for neonatal and adult human microvascular endothelial cells (HMVEC), re...

journal_title：Biochemical and biophysical research communications

authors： Ohmi K,Kiyokawa N,Takeda T,Fujimoto J

更新日期：1998-10-09 00:00:00

abstract：:The internucleosomal cleavage of genomic DNA is a biochemical hallmark of apoptosis. DNase gamma, a Mg2+/Ca2+-dependent endonuclease, has been suggested to be one of the apoptotic endonucleases, but its biochemical characteristic has not been fully elucidated. Here, using recombinant DNase gamma, we showed that DNase ...

journal_title：Biochemical and biophysical research communications

authors： Mizuta R,Mizuta M,Araki S,Shiokawa D,Tanuma S,Kitamura D

更新日期：2006-06-30 00:00:00

abstract：:The present study characterizes constitutively expressed rat testicular interleukin-1alpha (IL-1alpha) proteins. IL-1 bioactivity of crude testis protein was completely neutralized by IL-1alpha antiserum, IL-1 receptor antagonist, and soluble type I IL-1 receptor. Upon non-denaturating gel permeation chromatography, b...

journal_title：Biochemical and biophysical research communications

authors： Gustafsson K,Sultana T,Zetterström CK,Setchell BP,Siddiqui A,Weber G,Söder O

更新日期：2002-09-27 00:00:00

abstract：:The inhibitory effect of sodium selenite on biliary secretion of methyl mercury was examined in rats. The biliary secretion of methyl mercury in rat treated with 1 mumol/kg of methyl mercury was significantly decreased by administration of selenite at doses of 0.05 mumol/kg or higher. In rats given 10 mumol/kg of meth...

journal_title：Biochemical and biophysical research communications

authors： Urano T,Imura N,Naganuma A

更新日期：1997-10-29 00:00:00

abstract：:To investigate the maturation of neonatal erythrocytes and kinetics of globin expression, we induced CD34(+) cells purified from human umbilical cord blood to erythroid differentiation in different suspension culture systems containing human cord serum (CHS) and adult serum (AHS), respectively. The zeta- to alpha-glob...

journal_title：Biochemical and biophysical research communications

authors： Zhang X,Luo YM,Ma YN,Zhang JW

更新日期：2005-10-14 00:00:00

abstract：:Binding of phorbol-12,13-dibutyrate (PDBu), a tumor promoter, to quiescent Swiss 3T3 cells increased the number of hexose carriers, resulting in stimulation of membrane transport of 3-O-methylglucose (3MeGlu) in a Ca2+-dependent fashion. Extracellular Ca2+ was necessary to initiate the binding of PDBu to its receptor,...

journal_title：Biochemical and biophysical research communications

authors： Kitagawa K,Nishino H,Iwashima A

更新日期：1985-04-16 00:00:00

abstract：:The effect of silkworm hemolymph on baculovirus-induced insect cell apoptosis was investigated. The addition of silkworm hemolymph into the culture medium either before or during the baculovirus infection increased the host cell longevity; however, its addition after the infection was less effective. This can be expla...

journal_title：Biochemical and biophysical research communications

authors： Rhee WJ,Park TH

更新日期：2000-04-29 00:00:00

abstract：:The thermophilic, obligately chemolithoautotrophic hydrogen-oxidizing bacterium, Hydrogenobacter thermophilus TK-6, assimilates carbon dioxide via the reductive tricarboxylic acid cycle. A gene cluster, porEDABG, encoding pyruvate:ferredoxin oxidoreductase (POR), which plays a key role in this cycle, was cloned and se...

journal_title：Biochemical and biophysical research communications

authors： Ikeda T,Ochiai T,Morita S,Nishiyama A,Yamada E,Arai H,Ishii M,Igarashi Y

更新日期：2006-02-03 00:00:00

abstract：:The Ca(2+)-binding proteins regulate a number of cellular and extracellular activities and deregulations of S100 gene expression are associated with several human diseases. For example, S100A7 is upregulated in psoriatic skin, implicating a link with psoriasis, a chronic inflammatory dermatosis. We purified human S100...

journal_title：Biochemical and biophysical research communications

authors： Bürgisser DM,Siegenthaler G,Kuster T,Hellman U,Hunziker P,Birchler N,Heizmann CW

更新日期：1995-12-05 00:00:00

abstract：:Neural stem cells (NSCs) have the potential for differentiation into neurons known as a groundbreaking therapeutic solution for central nervous system (CNS) diseases. To resolve the therapeutic efficiency of NSCs, recent researchers have focused on the study on microRNA's role in CNS. Some micro RNAs have been reporte...

journal_title：Biochemical and biophysical research communications

authors： Song J,Cho KJ,Oh Y,Lee JE

更新日期：2015-07-10 00:00:00

abstract：:The recently deorphanized niacin receptor subtypes NIACR1 (GPR109A) and NIACR2 (GPR109B) play an essential role in the regulation of metabolic processes and immune reactions. Both receptors belong to the G-protein-coupled receptor (GPCR) family, whose members have traditionally been treated as monomeric entities, but ...

journal_title：Biochemical and biophysical research communications

authors： Mandrika I,Petrovska R,Klovins J

更新日期：2010-04-30 00:00:00

abstract：:Down syndrome (DS) leads to cardiac defects which are common and significant in babies with DS. We recently generated chimeric mice carrying a human chromosome (hChr) 21. The contribution ratio of embryonic stem (ES) cells containing a hChr 21 was specifically low in the heart, compared to other organs, and cardiovasc...

journal_title：Biochemical and biophysical research communications

authors： Inoue T,Shinohara T,Takehara S,Inoue J,Kamino H,Kugoh H,Oshimura M

更新日期：2000-06-24 00:00:00

abstract：:The effect of calcitonin gene-related peptide(CGRP) on the release of atrial natriuretic peptide(ANP) was studied in spontaneously beating, isolated rat atria. CGRP stimulated the ANP release in a dose-dependent manner. When the atria were incubated with a combination of phentolamine, propranolol, and atropine, these ...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto A,Kimura S,Hasui K,Fujisawa Y,Tamaki T,Fukui K,Iwao H,Abe Y

更新日期：1988-09-30 00:00:00

abstract：:The human elafin gene was cloned and its entire nucleotide sequence was determined to deduce the amino acid sequence for the precursor of elafin, an elastase-specific inhibitor. The gene spans approximately 1.7 kb and is divided into 3 exons. The gene product preproelafin consists of 117 amino acids: the initiator Met...

journal_title：Biochemical and biophysical research communications

authors： Saheki T,Ito F,Hagiwara H,Saito Y,Kuroki J,Tachibana S,Hirose S

更新日期：1992-05-29 00:00:00

abstract：:The methionine sulfoxide reductase (Msr) family of enzymes has been shown to protect cells against oxidative damage. The two major Msr enzymes, MsrA and MsrB, can repair oxidative damage to proteins due to reactive oxygen species, by reducing the methionine sulfoxide in proteins back to methionine. A role of MsrA in a...

journal_title：Biochemical and biophysical research communications

authors： Cudic P,Joshi N,Sagher D,Williams BT,Stawikowski MJ,Weissbach H

更新日期：2016-01-22 00:00:00

abstract：:A novel nuclear magnetic resonance (NMR) spectroscopy probe was designed and constructed for the study of transient metabolic changes in cellular systems during exposure to ionizing radiation. The probe incorporated a bioreactor, a radiation source, and a radiofrequency detection circuit tunable between 100 and 300 MH...

journal_title：Biochemical and biophysical research communications

authors： Magness JE,McFarland EW

更新日期：1997-04-07 00:00:00

abstract：:Multidrug resistance protein 4 (MRP4) is a member of subfamily C of the ATP-binding cassette superfamily of membrane transport proteins. MRP4 mediates the ATP-dependent efflux of many endogenous and exogenous solutes across the plasma membrane, and in polarized cells, it localizes to the apical or basolateral plasma m...

journal_title：Biochemical and biophysical research communications

authors： Miah MF,Conseil G,Cole SP

更新日期：2016-01-22 00:00:00

abstract：:Human platelets prelabeled with arachidonate exhibited a rapid and transient rise in arachidonoyl monoglyceride in addition to arachidonoyl diglyceride following thrombin stimulation. Substantial release of arachidonate and its metabolites also occurred at the early phase. Preincubation of labeled platelets with RHC 8...

journal_title：Biochemical and biophysical research communications

authors： Chau LY,Tai HH

更新日期：1983-05-31 00:00:00

abstract：:Pancreatic cancers are resistant to TNF-alpha-mediated apoptosis. Silencer of death domains (SODD) binds to TNF-alpha receptor TNFR-1, and prevents spontaneous self-association of death domains and inappropriate receptor signaling. In addition, overexpression of SODD suppresses TNF-alpha-induced cell death. In this re...

journal_title：Biochemical and biophysical research communications

authors： Ozawa F,Friess H,Zimmermann A,Kleeff J,Büchler MW

更新日期：2000-05-10 00:00:00

abstract：:Research on stem-cell transplantation has indicated that the success of transplantation largely depends on synchronizing donor cells into the G0/G1 phase. In this study, we investigated the profile of embryonic stem (ES) cell synchronization and its effect on the formation of embryonic bodies (EBs) using cell culture ...

journal_title：Biochemical and biophysical research communications

authors： Zhang E,Li X,Zhang S,Chen L,Zheng X

更新日期：2005-08-12 00:00:00

abstract：:For a series of adenosine analogues a close correlation (r = 0.986) was found between their antiviral potency (against vesicular stomatitis virus) and their inhibitory effects (Ki/Km) on S-adenosylhomocysteine (AdoHcy) hydrolase; thus, in order of increasing inhibitory potency for both virus replication and AdoHcy hyd...

journal_title：Biochemical and biophysical research communications

authors： De Clercq E,Cools M

更新日期：1985-05-31 00:00:00

abstract：:Prior studies have identified molecules involved in IL-1 signaling that transmit the extracellular stimulus to downstream kinase molecules causing altered transcriptional activity. Many of these investigations have relied heavily on ligand induced protein-protein interactions detected by immuno-coprecipitation to map ...

journal_title：Biochemical and biophysical research communications

authors： Boch JA,Yoshida Y,Koyama Y,Wara-Aswapati N,Peng H,Unlu S,Auron PE

更新日期：2003-04-04 00:00:00