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GnRH neuron type-specific transcriptome analysis by laser captured single-cell microarray in the medaka.

Abstract：

:Most vertebrates possess at least two gonadotropin-releasing hormone (GnRH) neuron types. To understand the physiological significance of the multiple GnRH systems in the brain, we examined three GnRH neuron type-specific transcriptomes using single-cell microarray analyses in the medaka (Oryzias latipes). A microarray profile of the three GnRH neuron types revealed five genes that are uniquely expressed in specific GnRH neuron types. GnRH1 neurons expressed three genes that are homologous to functionally characterised genes, GnRH2 neurons uniquely expressed one unnamed gene, and GnRH3 neurons uniquely expressed one known gene. These genes may be involved in the modulation or maintenance of each GnRH neuron type.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Moriya S,Ogawa S,Parhar IS

doi

10.1016/j.bbrc.2013.05.004

subject

Has Abstract

pub_date

2013-06-14 00:00:00

pages

562-6

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(13)00774-2

journal_volume

435

pub_type

杂志文章

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