ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin.

abstract：:Multiple deletions of mtDNA have not only been implicated in aging, but also in a wide variety of pathological conditions. The enzyme system used in long-PCR makes it possible to synthesize the entire mitochondrial genome (16.5 kb), exposing the multiple deletions in mtDNAs implicated in and, at least partially, respo...

journal_title：Biochemical and biophysical research communications

authors： Reynier P,Malthiery Y

更新日期：1995-12-05 00:00:00

abstract：:Based on molecular modelling study, we propose that the reaction between L-aspartate an carbamoylphosphate, catalyzed by E. coli aspartate carbamoyltransferase, may proceed via a tetrahedral intermediate and that the breakdown of the intermediate is facilitated by an intramolecular proton transfer between the amino gr...

journal_title：Biochemical and biophysical research communications

authors： Gouaux JE,Krause KL,Lipscomb WN

更新日期：1987-02-13 00:00:00

abstract：:It has been suggested that the positive inotropic effect of the vasoactive peptide hormone, endothelin-1 (ET-1), involves inhibition of cardiac K(+) currents. In order to identify the K(+) currents modulated by ET-1, the outward K(+) currents of isolated rat ventricular myocytes were investigated using whole-cell patc...

journal_title：Biochemical and biophysical research communications

authors： James AF,Ramsey JE,Reynolds AM,Hendry BM,Shattock MJ

更新日期：2001-06-22 00:00:00

abstract：:The second open reading frame of avian reovirus S1 gene segment encodes a 17 kDa non-structural protein, named p17. The biological role of p17 is fully unknown so far. Using trypan blue dye exclusion and MTT assay, we demonstrated that the ectopic expression of p17 results in the reduction of viable cell number and ce...

journal_title：Biochemical and biophysical research communications

authors： Liu HJ,Lin PY,Lee JW,Hsu HY,Shih WL

更新日期：2005-10-21 00:00:00

abstract：:The concept of a glycolytic cancer cell was introduced by Warburg over 70 years ago. This perception has since become the rationale that drives a considerable proportion of basic research on cancer, and it influences the current strategies for the diagnosis, monitoring, and treatment of cancer. Here we review the data...

journal_title：Biochemical and biophysical research communications

authors： Zu XL,Guppy M

更新日期：2004-01-16 00:00:00

abstract：:A spontaneous lymphoma was detected in mice, which was caused by a recessive autosomal mutation. The genetic basis was revealed to be a 5-bp deletion at the splicing donor site of the first intron of the FasL gene, resulting in aberrant transcripts coding for non-functional proteins. This mutation of the FasL gene cau...

journal_title：Biochemical and biophysical research communications

authors： Wang CC,Zeng Q,Hwang LA,Guo K,Li J,Liew HC,Hong W

更新日期：2006-10-13 00:00:00

abstract：:Sepiapterin reductase (SPR) is an enzyme that acts in the third and final step of tetrahydrobiopterin (BH4) biosynthesis. The human Spr gene locates within the region of 2.5MB mapped to PARK3, an autosomal dominant form of familial Parkinson's diseases. In order to explore the role of SPR in the metabolism of BH4, we ...

journal_title：Biochemical and biophysical research communications

authors： Takazawa C,Fujimoto K,Homma D,Sumi-Ichinose C,Nomura T,Ichinose H,Katoh S

更新日期：2008-03-21 00:00:00

abstract：:We have documented that the oncoprotein hepatitis B X-interacting protein (HBXIP) is able to promote migration of breast cancer cells. A subset of acetylated microtubules that accumulates in the cell leading edge is necessary for cell polarization and directional migration. In this study, we explored the hypothesis th...

journal_title：Biochemical and biophysical research communications

authors： Li L,Liu B,Zhang X,Ye L

更新日期：2015-03-13 00:00:00

abstract：:The tailspike protein (TSP) of bacteriophage P22 is a homotrimeric multifunctional protein responsible for recognition and hydrolysis of Salmonella typhimurium host receptors. Once properly folded, TSP shows an unusual stability to temperature and detergent denaturation, prompting the analysis of TSP as a framework fo...

journal_title：Biochemical and biophysical research communications

authors： Carbonell X,Villaverde A

更新日期：1998-03-17 00:00:00

abstract：:A 2.1-kb genomic region responsible for Ogawa serotype specificity of Vibrio cholerae 01 was identified by cosmid cloning and recombinant plasmid experiments. The plasmid carrying this region derived from Ogawa type Vibrio cholerae NIH 41 coded for a specific protein of 27 kD, and was found to convert serotype specifi...

journal_title：Biochemical and biophysical research communications

authors： Ito T,Ohshita Y,Nakamoto T,Hiramatsu K,Yokota T

更新日期：1991-03-15 00:00:00

abstract：:Regulation of the cAMP-elevating effects of isoproterenol and forskolin in cardiac myocytes by treatments that cause increases in cAMP. We have found that elevations in cyclic AMP (cAMP) have long-term effects on both the beta-adrenergic receptor and adenylyl cyclase in cultured chick ventricular myocytes. Pretreatmen...

journal_title：Biochemical and biophysical research communications

authors： Cui H,Green RD

更新日期：2003-07-18 00:00:00

abstract：:Regulatory T cells (Treg cells) are crucial for the maintenance of immunological tolerance, and it has been reported that Treg cells are enriched within the tumor micro-environment for immune evasion due to their immunosuppressive functions. To inhibit Treg cells functions, FoxP3, a lineage-specific transcription fact...

journal_title：Biochemical and biophysical research communications

authors： Park JH,Ko JS,Shin Y,Cho JY,Oh HA,Bothwell AL,Lee SK

更新日期：2014-08-15 00:00:00

abstract：:beta-Amyloid peptide (beta A) is a major fibrillar component of neuritic plaques in Alzheimer's disease (AD) brains and is related to the pathogenesis of the disease. In this study, using electron microscopy, we describe herein the results concerning the efficacy of compounds that can dissolve preformed beta A fibrils...

journal_title：Biochemical and biophysical research communications

authors： Nguyen KV,Gendrault JL,Wolff CM

更新日期：2002-03-08 00:00:00

abstract：:P1-(adenosine-5')-P3-(glucose-6)-triphosphate (Ap3glucose) is a linear uncompetitive inhibitor vs glucose and a linear mixed inhibitor vs ATP of brain hexokinase, an inhibition pattern inconsistent with binding of Ap3glucose to the catalytic site when either the rapid equilibrium random or ordered sequential mechanism...

journal_title：Biochemical and biophysical research communications

authors： Manning TA,Wilson JE

更新日期：1984-01-13 00:00:00

abstract：:The production of hydroxyl radicals by tetrachlorohydroquinone (TCHQ, a major metabolite of the widely used biocide pentachlorophenol) in the presence of H(2)O(2) was studied by salicylate hydroxylation method. HPLC with electrochemical detection was used to measure the levels of 2,3- and 2,5-dihydroxybenzoic acid (DH...

journal_title：Biochemical and biophysical research communications

authors： Zhu BZ,Kitrossky N,Chevion M

更新日期：2000-04-21 00:00:00

abstract：:Previously, we showed that several minor macromolecular glycolipids accounting for less than 5% of the lipoteichoic acid (LTA) fraction from Enterococcus hirae ATCC 9790 possess cytokine-inducing activity, whereas the purified LTA does not. In other words, the immunobiological activity of the LTA fraction reported in ...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto M,Imamura Y,Morichika T,Arimoto K,Takeuchi O,Takeda K,Akira S,Aoyama K,Tamura T,Kotani S,Suda Y,Kusumoto S

更新日期：2000-06-24 00:00:00

abstract：:The activation of c-jun N-terminal kinase (JNK) in pancreatic islets is associated with impaired function and viability, and JNK inhibitory peptides (JNKIs) are cytoprotective. In particular, l-isoforms of JNKIs were shown to improve islets viability, while the d-retroinverso isoform of JNKI (RI-JNKI), with a higher t...

journal_title：Biochemical and biophysical research communications

authors： Fornoni A,Cobianchi L,Sanabria NY,Pileggi A,Molano RD,Ichii H,Rosero S,Inverardi L,Ricordi C,Pastori RL

更新日期：2007-03-02 00:00:00

abstract：:CD30, a member of the TNF receptor family, has been implicated in the activation of T cells and B cells. In the present study, we characterized the expression and function of murine CD30 ligand (mCD153) by utilizing mCD153 transfectants and a novel mAb against mCD153 (RM153), which can inhibit the binding of murine CD...

journal_title：Biochemical and biophysical research communications

authors： Shimozato O,Takeda K,Yagita H,Okumura K

更新日期：1999-03-24 00:00:00

abstract：PURPOSE:Kirsten rat sarcoma (KRAS) gene mutations occur early in the progression of colorectal adenoma to carcinoma. The mutation status of the KRAS gene determines the benefits of molecular targeting drugs in patients with advanced colorectal cancer, although many methods are available to detect such mutations. The pu...

journal_title：Biochemical and biophysical research communications

authors： Kobunai T,Watanabe T,Yamamoto Y,Eshima K

更新日期：2010-04-23 00:00:00

abstract：:3'-Azido-3'-deoxythymidine-5'-phosphate diglyceride (16:0/18:1 omega 9), a phosphatic acid conjugate of AZT, is active against HIV replication in H9 cells and syncytia formation in MOLT-3 cells. The activities rank as AZT greater than pure conjugate greater than conjugate in mixed liposomes, with the pure conjugate ha...

journal_title：Biochemical and biophysical research communications

authors： Steim JM,Camaioni Neto C,Sarin PS,Sun DK,Sehgal RK,Turcotte JG

更新日期：1990-08-31 00:00:00

abstract：:A Clostridium thermocellum gene (licB) encoding a thermoactive 1,3-1,4-beta-glucanase (lichenase) with a molecular weight of about 35,000 was localized on a 1.5-kb DNA fragment by cloning and expression in E. coli. The enzyme acts on beta-glucans with alternating beta-1,3- and beta-1,4-linkages such as barley beta-glu...

journal_title：Biochemical and biophysical research communications

authors： Schimming S,Schwarz WH,Staudenbauer WL

更新日期：1991-05-31 00:00:00

abstract：:Constitutive and PKC-regulated alpha-secretase pathways have been reported to produce the secreted form of alpha-secretase-derived APP (sAPPalpha). Here, we examined putative role of furin in the regulation of alpha-secretase activity in vitro and in vivo. Overexpression of the prodomain of furin and infection with a ...

journal_title：Biochemical and biophysical research communications

authors： Hwang EM,Kim SK,Sohn JH,Lee JY,Kim Y,Kim YS,Mook-Jung I

更新日期：2006-10-20 00:00:00

abstract：:Planar bilayer studies are reported on the channel activity of des-L X Val7-D X Val8-Gramicidin A. This analog is designed to provide more long-lived side chain distributions involving the Trp residues than occur with Gramicidin A. The carbonyls of these residues coordinate the permeant cation and the energetics of th...

journal_title：Biochemical and biophysical research communications

authors： Urry DW,Alonso-Romanowski S,Venkatachalam CM,Harris RD,Prasad KU

更新日期：1984-02-14 00:00:00

abstract：:The mechanism by which lithium (Li(+)) inhibits the protein kinase glycogen synthase kinase-3 (GSK-3) is unknown. Here, we demonstrate that Li(+) is a competitive inhibitor of GSK-3 with respect to magnesium (Mg(2+)), but not to substrate or ATP. This mode of inhibition is conserved between mammalian and Dictyostelium...

journal_title：Biochemical and biophysical research communications

authors： Ryves WJ,Harwood AJ

更新日期：2001-01-26 00:00:00

abstract：:We examined the expression of P-glycoprotein in human placentas and hydatidiform moles. Trophoblasts in all the examined placentas and moles expressed P-glycoprotein, and the size of the P-glycoprotein was smaller than that in multidrug-resistant human epidermoid carcinoma KB cells. The P-glycoprotein in the placenta ...

journal_title：Biochemical and biophysical research communications

authors： Nakamura Y,Ikeda S,Furukawa T,Sumizawa T,Tani A,Akiyama S,Nagata Y

更新日期：1997-06-27 00:00:00

abstract：:Our recent study (Saiki, Y., and Ikemoto, N., Biochemistry 38, 3112-3119, 1999) suggests that Ca2+ release and re-uptake of the released Ca2+ are coordinated. The following results suggest that the coordination is mediated by the luminal Ca2+ ([Ca2+]lum) transient. Upon inducing the release of the passively loaded Ca2...

journal_title：Biochemical and biophysical research communications

authors： Ikemoto N,Yamamoto T

更新日期：2000-12-29 00:00:00

abstract：:RNA primer removal during DNA replication is dependent on ribonucleotide- and structure-specific RNase H and FEN-1 nuclease activities. A specific RNase H involved in this reaction has long been sought. RNase HII is the only open reading frame in Archaeoglobus fulgidus genome, while multiple RNases H exist in eukaryot...

journal_title：Biochemical and biophysical research communications

authors： Chai Q,Qiu J,Chapados BR,Shen B

更新日期：2001-09-07 00:00:00

abstract：:Metabolic syndrome describes a group of clinical features that together increase the incidence of coronary artery disease, stroke and type 2 diabetes. Insulin resistance is a major risk factor for developing metabolic syndrome. A chronic state of inflammation accompanies the accumulation of surplus lipids in adipose a...

journal_title：Biochemical and biophysical research communications

authors： Ko SH,Lee JK,Lee HJ,Ye SK,Kim HS,Chung MH

更新日期：2014-01-10 00:00:00

abstract：:HMGB proteins are abundant, non-histone proteins in eukaryotic chromatin. HMGB proteins contain one or two conserved "HMG boxes" and can be sequence-specific or nonspecific in their DNA binding. HMGB proteins cause strong DNA bending and bind preferentially to deformed DNAs. We wish to understand how HMGB proteins inc...

journal_title：Biochemical and biophysical research communications

authors： Zimmerman J,Maher LJ 3rd

更新日期：2008-06-20 00:00:00

abstract：:The small heat shock protein hsp27 is associated with aggressive tumor behavior in certain subsets of breast cancer patients. Previously we demonstrated that hsp27 overexpression in breast cancer cells increased in vitro and in vivo invasiveness, suggesting that hsp27 influences the metastatic process. To investigate ...

journal_title：Biochemical and biophysical research communications

authors： Hansen RK,Parra I,Hilsenbeck SG,Himelstein B,Fuqua SA

更新日期：2001-03-23 00:00:00