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pp60c-src expression in rat spermatogenesis.

Abstract：

:A fractionation of the membrane extract of rat testes revealed the existence of pp60c-src kinase activity. The expression of pp60c-src was examined in the developing rat testes. The immunecomplex kinase assay using a monoclonal antibody specific to pp60c-src (mAb327) showed that the expression of pp60c-src kinase activity increased during the development of rat testes and declined in the adult. The increase in pp60c-src kinase activity observed during the development of rat testes was accompanied with an increase in the amount of pp60c-src protein. The peak period in the increase of pp60c-src kinase activity well coincided with the timing, when the spermatogenesis by meiosis just began. The immunohistochemical staining of pp60c-src in rat testes demonstrated that pp60c-src is most abundantly expressed in the spermatids which are the spermatogenic cells in the post-meiotic phase of the spermatogenesis. These findings strongly suggest that pp60c-src is a developmentally regulated gene product which is involved in rat spermatogenesis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Nishio H,Tokuda M,Itano T,Matsui H,Takeuchi Y,Hatase O

doi

10.1006/bbrc.1995.1072

subject

Has Abstract

pub_date

1995-01-17 00:00:00

pages

502-10

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)71072-8

journal_volume

206

pub_type

杂志文章

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