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Parathyroid hormone-related protein is a possible autocrine growth inhibitor for lymphocytes.

Abstract：

:Adult T-cell leukemia (ATL)-related cells have the ability to produce a newly-isolated calcium-regulating protein, parathyroid hormone-related protein (PTHrP). The present study revealed that lectin-stimulated normal lymphocytes produce immunoreactive (IR)-PTHrP. When the T-cell-enriched fraction was purified from normal lymphocytes and then treated with lectin, a similar amount of IR-PTHrP was detected, suggesting that IR-PTHrP is an actual product of T-lymphocytes. A biologically active fragment of PTHrP, PTHrP(1-34), suppressed DNA synthesis in lectin-stimulated lymphocytes at concentrations greater than 50 pg/mL; the same concentration range of IR-PTHrP detected in the cultured media of lectin-stimulated lymphocytes. Therefore, it is reasonable to postulate that PTHrP is a cytokine inhibiting the cellular growth of normal lymphocytes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Adachi N,Yamaguchi K,Miyake Y,Honda S,Nagasaki K,Akiyama Y,Adachi I,Abe K

doi

10.1016/0006-291x(90)90978-v

subject

Has Abstract

pub_date

1990-02-14 00:00:00

pages

1088-94

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(90)90978-V

journal_volume

166

pub_type

杂志文章

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