High affinity binding of human interleukin 4 to cell lines.

abstract：:Iron administration to HeLa cells stimulates the accumulation of H-subunit and L-subunit rich isoferritins at similar extent. The increase in both types of isoferritins is accompanied by an increase in the amount of messenger RNAs specific for H and L subunits. The increase in the amount of these messenger RNAs, which...

journal_title：Biochemical and biophysical research communications

authors： Cairo G,Bardella L,Schiaffonati L,Arosio P,Levi S,Bernelli-Zazzera A

更新日期：1985-11-27 00:00:00

abstract：:Stimulation of leucine uptake by addition of concanavalin A, mediated by increase of intracellular free Ca2+ concentration [( Ca2+]), in lymphocytes (Mitsumoto, Y., Sato, K. and Mohri, T. (1988) Biochim. Biophys. Acta 968, 353-358) was abolished by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and chlorprom...

journal_title：Biochemical and biophysical research communications

authors： Sato K,Mitsumoto Y,Mohri T

更新日期：1988-06-16 00:00:00

abstract：:A circadian rhythm in the concentrations of prostaglandins (PG) E2, PGF2, PGI2 (measured as 6-keto-PGF1 alpha), immunoreactive h hydroxyeicosatetraenoic acids and immunoreactive 6-sulfidopeptide containing leukotrienes in human mixed saliva was observed. The rhythm reflected changes in the absolute amounts of these co...

journal_title：Biochemical and biophysical research communications

authors： Rigas B,Levine L

更新日期：1983-08-30 00:00:00

abstract：:DNA bending has been shown to play a critical role in conservative site-specific DNA recombination reactions such as lambda integration. V(D)J recombination, the only mammalian site directed recombination system, is directed by recombinational signal sequences composed of heptamer, nonamer and spacer elements. The non...

journal_title：Biochemical and biophysical research communications

authors： Andrews R,Halligan NL,Halligan BD

更新日期：1993-05-28 00:00:00

abstract：:A soluble protein that binds malonyl-CoA without requiring cofactors has been purified from rat liver. Until saturated, it competes with fatty acid synthetase for free malonyl-CoA, temporarily reducing the rate of fatty acid synthesis at low levels of malonyl-CoA, as in fatty acid synthetase--coupled assays for acetyl...

journal_title：Biochemical and biophysical research communications

authors： Dugan RE,Osterlund BR,Drong RF,Swenson TL

更新日期：1987-08-31 00:00:00

abstract：:Rats consume most of their daily food intake at night; serum leptin levels and adipose tissue leptin mRNA content are elevated at night in non-lactating rats fed ad libitum. Lactation induces massive hyperphagia with most food still consumed at night, but the nocturnal increase in leptin secretion was not observed in ...

journal_title：Biochemical and biophysical research communications

authors： Pickavance L,Tadayyon M,Williams G,Vernon RG

更新日期：1998-07-09 00:00:00

abstract：:Dexamethasone (Dex) causes osteoblast cell injuries. In the present research, we tested the potential effect of SC79, a novel and specific Akt activator, against Dex in osteoblasts. In primary murine osteoblasts and osteoblastic MC3T3-E1 cells, pretreatment with SC79 significantly attenuated Dex-induced cell death. Fu...

journal_title：Biochemical and biophysical research communications

authors： Li ST,Chen NN,Qiao YB,Zhu WL,Ruan JW,Zhou XZ

更新日期：2016-10-07 00:00:00

abstract：:Incubation of purified bovine photoreceptor rod outer segments with [gamma-32P]ATP resulted in the labeling of phosphatidylinositol 4-phosphate (PIP) and phosphatidic acid (PA) with little labeling of phosphatidylinositol 4,5-bisphosphate (PIP2). Propranolol inhibited in a dose-dependent manner the labeling of PA and ...

journal_title：Biochemical and biophysical research communications

authors： Van Rooijen LA,Bazan NG

更新日期：1986-01-14 00:00:00

abstract：:Oxidative stress is widely involved in pathophysiological processes of cardiac remodeling. Molecules associated with antioxidant functions may be ideal targets for reversing cardiac remodeling. Sestrin2 is the important component of endogenous antioxidant defense, while there is little information on the pathophysiolo...

journal_title：Biochemical and biophysical research communications

authors： Du JX,Wu JZ,Li Z,Zhang C,Shi MT,Zhao J,Jin MW,Liu H

更新日期：2019-04-30 00:00:00

abstract：:Previous experiments have demonstrated that the intermediary metabolite 6-hydroxymethylbenzo[a] pyrene (HMBP) can be activated to the electrophilic mutagen, 6-sulfooxymethylbenzo[a]pyrene (SMBP), by rat and mouse liver PAPS-dependent sulfotransferase activity or by chemical synthesis. This aralkylating metabolite and ...

journal_title：Biochemical and biophysical research communications

authors： Flesher JW,Horn J,Lehner AF

更新日期：1997-05-29 00:00:00

abstract：:Triple A syndrome is an autosomal recessive neurological disease, mimicking motor neuron disease, and is caused by mutant ALADIN, a nuclear-pore complex component. We recently discovered that the pathogenesis involved impaired nuclear import of DNA repair proteins, including DNA ligase I and the cerebellar ataxia caus...

journal_title：Biochemical and biophysical research communications

authors： Kiriyama T,Hirano M,Asai H,Ikeda M,Furiya Y,Ueno S

更新日期：2008-10-03 00:00:00

abstract：:The cardiotoxin analogue III (CTX III), isolated from the Taiwan Cobra venom (Naja naja atra), is a sixty amino acid, all beta-sheet protein. The 2,2,2-trifluoro ethanol (TFE) induced unfolding of CTX III is studied under acidic conditions (pH 2.5). Using circular dichroism, 1-anilino-8-napthalene sulphonic acid bindi...

journal_title：Biochemical and biophysical research communications

authors： Kumar TK,Jayaraman G,Lee CS,Sivaraman T,Lin WY,Yu C

更新日期：1995-02-15 00:00:00

abstract：:A Cl- channel protein of sarcoplasmic reticulum (SR) was purified by assaying the channel activity in a planar lipid bilayer system. The light fraction of SR vesicles was solubilized in CHAPS and fractioned by anion exchange, gel filtration, and affinity chromatography with concanavalin A. All fractions in each step w...

journal_title：Biochemical and biophysical research communications

authors： Ide T,Sakamoto H,Morita T,Taguchi T,Kasai M

更新日期：1991-04-15 00:00:00

abstract：:The 2',3'-dideoxyriboside of 2,6-diaminopurine (ddDAPR) and its 2',3'-didehydro derivative (ddeDAPR) are poor substrates for adenosine deaminase (ADA) but potent inhibitors of the enzyme. Their Km values for ADA are of the same order of magnitude as those of the natural adenosine (Ado) and 2'-deoxyadenosine (dAdo), bu...

journal_title：Biochemical and biophysical research communications

authors： Balzarini J,Robins MJ,Zou RM,Herdewijn P,De Clercq E

更新日期：1987-05-29 00:00:00

abstract：:The effect of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of cholesterol synthesis with marked hypocholesterolemic activity, on the intestinal absorption of exogenous cholesterol has been studied in lymph-cannulated rats. Administration of the 15-ketosterol at a level of 0.05% in a rat chow diet for ...

journal_title：Biochemical and biophysical research communications

authors： Schroepfer GJ Jr,Christophe A,Needleman DH,Kisic A,Sherrill BC

更新日期：1987-08-14 00:00:00

abstract：:A novel aa3-type cytochrome oxidase from the extremely halophilic archaeon, Halobacterium halobium, differs significantly from those of other prokaryotic and eukaryotic cytochrome oxidases (Fujiwara, T., Fukumori, Y., and Yamanaka, T. (1989) J. Biochem. 105, 287-292). In the present study, we cloned and sequenced the ...

journal_title：Biochemical and biophysical research communications

authors： Denda K,Fujiwara T,Seki M,Yoshida M,Fukumori Y,Yamanaka T

更新日期：1991-11-27 00:00:00

abstract：:High expression of Rad51, the catalytic component in homologous recombination, has been reported to contribute to genomic instability. To elucidate biological processes related to Rad51, we performed global gene expression analysis on human fibrosarcoma cells induced to express variable Rad51 levels. The results indic...

journal_title：Biochemical and biophysical research communications

authors： Orre LM,Fält S,Szeles A,Lewensohn R,Wennborg A,Flygare J

更新日期：2006-03-10 00:00:00

abstract：:The aim of current study was to elucidate whether aquaporin-9 (AQP9) expression was involved in the progression of bone loss induced by microgravity. We used the hind-limb suspension (HLS) mice model to simulate microgravity and induce bone loss. It was found that HLS exposure decreased femur bone mineral density (BMD...

journal_title：Biochemical and biophysical research communications

authors： Bu G,Shuang F,Wu Y,Ren D,Hou S

更新日期：2012-03-23 00:00:00

abstract：:We hypothesized that the mutational strand asymmetry is more strongly exerted upon the mitochondrial cytochrome b (Cytb) gene, which is distant from the origin of the light-strand replication (Ori(L)), than upon the ATPase subunit 6 (ATP6) gene, which is close to the Ori(L). To test this hypothesis, we determined the ...

journal_title：Biochemical and biophysical research communications

authors： Fuku N,Oshida Y,Takeyasu T,Guo LJ,Kurata M,Yamada Y,Sato Y,Tanaka M

更新日期：2002-02-01 00:00:00

abstract：:Chromatin-associated high mobility group (HMG) proteins of the HMGB family are versatile architectural factors assisting various DNA-dependent processes such as transcription and recombination. Here, transgenic tobacco lines were generated that ectopically express the maize HMGB1 protein, as detected by immunoblot ana...

journal_title：Biochemical and biophysical research communications

authors： Lichota J,Ritt C,Grasser KD

更新日期：2004-05-21 00:00:00

abstract：:p38 MAPK and nuclear factor-B (NF-B) signaling pathways play an indispensable role in the control of skeletal myogenesis. The specific contribution of these signaling pathways to the response of myoblast to the mechanical stimulation and the molecular mechanisms underlying this response remain unresolved. Using an est...

journal_title：Biochemical and biophysical research communications

authors： Ji G,Liu D,Liu J,Gao H,Yuan X,Shen G

更新日期：2010-01-01 00:00:00

abstract：:Uveal melanoma (UM) is the most common primary intraocular tumor in adults. Despite of important progress in the local therapy, high radioresistance in primary tumor and chemoresistance in metastatic disease are the major obstacles for UM therapy. Therefore, strategies to overcome resistance to radiation or chemothera...

journal_title：Biochemical and biophysical research communications

authors： Zhang B,Wu H,Hao J,Wu Y,Yang B

更新日期：2020-02-12 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease, whose primary mechanisms or causes are still not defined and for which no effective treatment is available. We have recently reported that before disease onset the level of tyrosine nitrated proteins is increased in the G93A SOD1 transgenic mouse mod...

journal_title：Biochemical and biophysical research communications

authors： Massignan T,Casoni F,Basso M,Stefanazzi P,Biasini E,Tortarolo M,Salmona M,Gianazza E,Bendotti C,Bonetto V

更新日期：2007-02-16 00:00:00

abstract：:The aim of this study was to determine molecular mechanism(s) responsible for the reduced thymidine kinase activity (TK) observed earlier in an arabinosylcytosine (araC) resistant lymphoid cell line (H9-araC cells), which was obtained following continuous cultivation of H9 cells in the presence of 0.5 microM araC. Com...

journal_title：Biochemical and biophysical research communications

authors： Han T,Fernandez M,Sarkar M,Agarwal RP

更新日期：2003-08-01 00:00:00

abstract：:The influence of experimental conditions during long-time (72 h) incubations of neonatal mouse calvaria on the measurement of prostaglandins was investigated. Incubations of the cultured calvaria were carried out in the presence and absence of stimulating agents of bone resorption, such as thrombin and parathyroid hor...

journal_title：Biochemical and biophysical research communications

authors： Leis HJ,Malle E,Hoffmann O,Klaushofer K,Fratzl-Zelman N,Koller K,Peterlik M

更新日期：1990-06-15 00:00:00

abstract：:A protein designated mungin, isolated from mung bean (Phaseolus mungo) seeds, possessed activity against the fungi Rhizoctonia solani, Coprinus comatus, Mycosphaerella arachidicola, Botrytis cinerea, and Fusarium oxysporum. The 18-kDa protein also possessed a novel N-terminal sequence with similarity to cyclophilins. ...

journal_title：Biochemical and biophysical research communications

authors： Ye XY,Ng TB

更新日期：2000-07-14 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) has been shown to negatively regulate adipogenesis. To explore to what extent PGE(2) inhibits the differentiation of cells to adipocytes and to examine whether its effect could be due to EP4 receptor signaling, we used microarrays to analyze the gene expression profiles of 3T3-L1 cells expo...

journal_title：Biochemical and biophysical research communications

authors： Sugimoto Y,Tsuboi H,Okuno Y,Tamba S,Tsuchiya S,Tsujimoto G,Ichikawa A

更新日期：2004-09-24 00:00:00

abstract：:A human thyroid cDNA library was screened by hybridization with a dog thyrotropin receptor (TSHr) cDNA. Sequencing of the resulting clones identified a 2292 residue open reading frame encoding a 744 amino acid mature polypeptide presenting 90.3% similarity with the dog TSHr. Two major transcripts (4.6 and 4.4 kilobase...

journal_title：Biochemical and biophysical research communications

authors： Libert F,Lefort A,Gerard C,Parmentier M,Perret J,Ludgate M,Dumont JE,Vassart G

更新日期：1989-12-29 00:00:00

abstract：:Transforming growth factor beta (TGFbeta) is a critical immunosuppressive cytokine that inhibits the cell-mediated immune responses partly via inhibition of immunostimulatory cytokine production from T cells, NK cells, and macrophages. Here we investigated the effect of TGFbeta on NK cell activation induced by interle...

journal_title：Biochemical and biophysical research communications

authors： Hayashi H,Inoue Y,Tsutsui H,Okamura H,Nakanishi K,Onozaki K

更新日期：2003-01-24 00:00:00

abstract：:Bacillus alcalophilus, an obligately alkalophilic bacterium that grows at pH 11.0, has an intracellular pH of 9.5 or less. Unlike all other living organisms, polyamines (putrescine, spermidine and spermine) in B. alcalophilus, if present, will be largely unprotonated. HPLC analysis indicated that spermidine is the maj...

journal_title：Biochemical and biophysical research communications

authors： Chen KY,Cheng S

更新日期：1988-01-15 00:00:00