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Rad51-related changes in global gene expression.

Abstract：

:High expression of Rad51, the catalytic component in homologous recombination, has been reported to contribute to genomic instability. To elucidate biological processes related to Rad51, we performed global gene expression analysis on human fibrosarcoma cells induced to express variable Rad51 levels. The results indicate that Rad51 overexpression mediates late rather than early transcriptional responses. Using Gene Ontology analysis, we extracted functional annotations for Rad51-related changes in gene expression that were independent of general cell culture effects. High Rad51 levels conferred increased expression of genes involved in actin remodelling. These changes were accompanied by alterations in cell morphology. Moreover, core components of the mismatch repair (MMR) machinery were down-regulated in response to increased Rad51 expression. Given the role of MMR in the correction of DNA mismatches during replication and recombination, a concurrent increase in Rad51 levels and decrease in the expression of MMR genes could conceivably act synergistically towards genomic instability.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Orre LM,Fält S,Szeles A,Lewensohn R,Wennborg A,Flygare J

doi

10.1016/j.bbrc.2005.12.185

subject

Has Abstract

pub_date

2006-03-10 00:00:00

pages

334-42

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)02911-6

journal_volume

341

pub_type

杂志文章

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