Human salivary eicosanoids: circadian variation.

abstract：:The Monte Carlo method has been used to simulate the equilibrium properties of a planar array of 94 saturated lipid chains and one monomer of Gramicidin A. Chains are free to move laterally in the layer plane and to change conformation via gauche rotations and long axis rotations in a continuum. All non-hydrogen atoms...

journal_title：Biochemical and biophysical research communications

authors： Xing J,Scott HL

更新日期：1989-11-30 00:00:00

abstract：:Previous studies have extensively demonstrated the effect of endothelin-1 (ET-1), angiotensin II (Ang II), and TGF-β1 on the stimulation of collagen type I expression in cardiac myofibroblasts. However, the role of pro-remodeling peptides in the transcriptional regulation of the collagen promoter remains unclear. Thus...

journal_title：Biochemical and biophysical research communications

authors： Kisling A,Katwa LC

更新日期：2019-08-06 00:00:00

abstract：:Rat serosal mast cells were tested for their ability to generate a nitric oxide-like factor by two bioassay systems: inhibition of platelet aggregation and stimulation of mast cell guanylate cyclase. Incubation of rat serosal mast cells with human washed platelets resulted in an inhibition of thrombin-induced platelet...

journal_title：Biochemical and biophysical research communications

authors： Salvemini D,Masini E,Anggard E,Mannaioni PF,Vane J

更新日期：1990-06-15 00:00:00

abstract：:Due to the redundancy of the genetic code there exist six mRNA codons for arginine and several tRNA(Arg) isoacceptors which translate these triplets to protein within the context of the mRNA. The tRNA identity elements assure the correct aminoacylation of the tRNA with the cognate amino acid by the aminoacyl-tRNA-synt...

journal_title：Biochemical and biophysical research communications

authors： Eichert A,Perbandt M,Oberthür D,Schreiber A,Fürste JP,Betzel C,Erdmann VA,Förster C

更新日期：2009-07-17 00:00:00

abstract：:Metformin, a widely used anti-diabetic drug, is emerging as a potential anticancer agent but the mechanisms involved remain incompletely understood. Here, we demonstrate that the potency of metformin induced AMPK activation, as shown by the phosphorylation of its substrates acetyl-CoA carboxylase (ACC) at Ser(79) and ...

journal_title：Biochemical and biophysical research communications

authors： Sinnett-Smith J,Kisfalvi K,Kui R,Rozengurt E

更新日期：2013-01-04 00:00:00

abstract：:Cells of the sponge Microciona prolifera dissociated in Ca,Mg-free sea water reaggregate upon addition of Ca, an observation classically attributed to the requirement for Ca of a species-specific aggregation factor. We now report that, unexpectedly, extracellular Ca is not required during aggregation; brief Ca pulses ...

journal_title：Biochemical and biophysical research communications

authors： Dunham P,Weissmann G

更新日期：1986-02-13 00:00:00

abstract：:Long repeated stretches of d(CCG) and tri-nucleotide are crucial mutations that cause hereditary forms of mental retardation (fragile X-syndrome). Moreover, the alternating (CG) di-nucleotide is one of the candidates for Z-DNA conformation. Solution NMR structure of d(CCGCGG)(2) has been solved and is discussed. The d...

journal_title：Biochemical and biophysical research communications

authors： Monleón D,Esteve V,Celda B

更新日期：2003-03-28 00:00:00

abstract：:Nerve growth factor (NGF) immobilization on a culture substrate may dramatically reduce the amount of NGF required for pheochromocytoma (PC12) cell culture. Coverslips on which NGF had been immobilized, or with NGF added to the culture medium daily, were used to culture PC12 cells. We examined the effects of adding 5,...

journal_title：Biochemical and biophysical research communications

authors： Bhang SH,Lee TJ,Yang HS,La WG,Han AM,Kwon YH,Kim BS

更新日期：2009-05-01 00:00:00

abstract：:Glutamine catabolism is considered to be an important metabolic pathway for cancer cells. Glutaminase (GLS) is the important rate-limiting enzyme of glutamine catabolism. miR-137 functions as a tumor suppressor in many human malignant tumors. However, the role and molecular mechanism of miR-137 and GLS in malignant me...

journal_title：Biochemical and biophysical research communications

authors： Luan W,Zhou Z,Zhu Y,Xia Y,Wang J,Xu B

更新日期：2018-01-01 00:00:00

abstract：:We have demonstrated previously that patients with rheumatoid arthritis (RA) show an increase in serum and synovial fluid levels of complexes between alpha1-proteinase inhibitor (alpha1PI) and IgA. These are believed to form through disulfide binding between the Cys232 residue on alpha1PI and the penultimate cysteine ...

journal_title：Biochemical and biophysical research communications

authors： Scott LJ,Russell GI,Nixon NB,Dawes PT,Mattey DL

更新日期：1999-02-24 00:00:00

abstract：:In mammalian cells, the Rab7 protein is a key element of late endocytic membrane traffic. Several results suggest that it is involved in the transport from early to late endosome or from late endosome to lysosome. We have previously characterized a Rab7 gene homologue (TcRAB7) in Trypanosoma cruzi. Now, using an affin...

journal_title：Biochemical and biophysical research communications

authors： Araripe JR,Cunha e Silva NL,Leal ST,de Souza W,Rondinelli E

更新日期：2004-08-20 00:00:00

abstract：:Hypothalamic peptides, gonadotropin-releasing hormone (GnRH) and gonadotropin inhibitory hormone (GnIH), play pivotal roles in the control of reproduction and gonadal maturation in fish. In the present study we tested the possibility that stress-mediated reproductive dysfunction in teleost may involve changes in GnRH ...

journal_title：Biochemical and biophysical research communications

authors： Choi YJ,Habibi HR,Kil GS,Jung MM,Choi CY

更新日期：2017-04-01 00:00:00

abstract：:Activation of the classical complement pathway has been proposed as a mechanism of neurodegeneration in Alzheimer's disease. This activation is a result of the binding of C1q to amyloid beta-peptide (A beta). Recent work has shown that A beta/C1q binding has an additional consequence: enhanced formation of the neuroto...

journal_title：Biochemical and biophysical research communications

authors： Webster S,Glabe C,Rogers J

更新日期：1995-12-26 00:00:00

abstract：:Recent work identified an RNA binding protein whose presence in brain tumors correlated with translational repression of Glut1 expression. RNase T1 mapping demonstrated that this protein bound an AU-rich response element (AURE) in the Glut1 3'UTR. Facilitated by its differential expression in brain tumor cytosols, we ...

journal_title：Biochemical and biophysical research communications

authors： Hamilton BJ,Nichols RC,Tsukamoto H,Boado RJ,Pardridge WM,Rigby WF

更新日期：1999-08-11 00:00:00

abstract：:Cell division cycle protein 45 (Cdc45) is crucial for the initiation as well as the elongation process of eukaryotic DNA replication. Our findings suggested that the Cdc45 protein is ubiquitylated and degraded by the proteasome pathway in human cells. Firstly, the fate of Cdc45 protein after induction of terminal diff...

journal_title：Biochemical and biophysical research communications

authors： Pollok S,Grosse F

更新日期：2007-11-03 00:00:00

abstract：:A human isoform of the vesicle-associated membrane protein-associated proteins (VAPs), VAPB, causes amyotrophic lateral sclerosis eight due to the missense mutation of Pro-56, whereas human VAPA and the yeast VAP Scs2p proteins are not significantly affected by similar mutations. We have found that VAPA and Scs2p have...

journal_title：Biochemical and biophysical research communications

authors： Nakamichi S,Yamanaka K,Suzuki M,Watanabe T,Kagiwada S

更新日期：2011-01-14 00:00:00

abstract：:Accumulating evidence indicates that microRNAs function as oncogenes or tumor suppressor genes in human cancer. MiR-503 is deregulated in various human cancers and has been associated with hepatocellular carcinoma (HCC) progression. However, the underlying mechanisms of miR-503 involvement in the development and progr...

journal_title：Biochemical and biophysical research communications

authors： Li B,Liu L,Li X,Wu L

更新日期：2015-09-04 00:00:00

abstract：:This is the first systematic study on the pancreatic beta cell function in the heterozygous mouse with targeted disruption of the beta cell glucokinase gene. The heterozygotes' beta cell displayed the following characteristics: (1) impaired glucose sensitivity with normal glucose responsiveness, (2) poor discriminatio...

journal_title：Biochemical and biophysical research communications

authors： Aizawa T,Asanuma N,Terauchi Y,Suzuki N,Komatsu M,Itoh N,Nakabayashi T,Hidaka H,Ohnota H,Yamauchi K,Yasuda K,Yazaki Y,Kadowaki T,Hashizume K

更新日期：1996-12-13 00:00:00

abstract：:Prostate cancer has become one of commonest urologic tumors in male. In recent years, miRNAs are continually attracting attentions of researchers for their special regulatory function in human cancers. Previous study has revealed that miR-410 acts as a biomarker for the diagnosis of prostate cancer. Whereas, the speci...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Zhang D,Lv J,Wang S,Zhang Q

更新日期：2018-09-18 00:00:00

abstract：:Ras can become activated via multiple distinct receptors in T lymphocytes. However, mechanistic studies of Ras signaling in normal T cells have been hampered by the lack of an efficient technology for gene transfer into resting post-thymic cells. We have overcome this limitation by utilizing adenoviral transduction of...

journal_title：Biochemical and biophysical research communications

authors： Marks RE,Ho AW,Rivas F,Marshall E,Janardhan S,Gajewski TF

更新日期：2003-12-19 00:00:00

abstract：:T Kininogen and High Molecular Weight Kininogen were characterized in the cell culture medium of Fao cells, a highly differentiated cell line derived from the Reuber H35 rat hepatoma. Immunoreactive T Kininogen and High Molecular Weight Kininogen identified by direct and specific RIAs were indistinguishable from stand...

journal_title：Biochemical and biophysical research communications

authors： Baussant T,Michaud A,Bouhnik J,Savoie F,Alhenc-Gelas F,Corvol P

更新日期：1988-08-15 00:00:00

abstract：:D-ribose is cytotoxic for quiescent human lymphocytes and severely inhibits their PHA-induced proliferation at concentrations (25-50 mM) at which other simple sugars are ineffective. In order to explain these effects, DNA repair synthesis was evaluated in PHA-stimulated human lymphocytes treated with hydroxyurea and i...

journal_title：Biochemical and biophysical research communications

authors： Zunica G,Marini M,Brunelli MA,Chiricolo M,Franceschi C

更新日期：1986-07-31 00:00:00

abstract：:The pluripotency of embryonic stem cells (ESCs) is maintained by core pluripotency transcription factors, cofactors and several signaling pathways. RBM14 is a component of the para-speckle complex, which has been implicated in multiple important biological processes. The role of RBM14 in ESCs and lineage differentiati...

journal_title：Biochemical and biophysical research communications

authors： Chen G,Zhang D,Zhang L,Feng G,Zhang B,Wu Y,Li W,Zhang Y,Hu B

更新日期：2018-06-18 00:00:00

abstract：:In the present study, we investigated if Cl(-) regulates the proliferation of the MC3T3-E1 osteoblastic cells. The proliferation of MC3T3-E1 osteoblastic cells was diminished by lowering the extracellular Cl(-) concentration ([Cl(-)](o)) in the culture medium. The lowered in [Cl(-)](o) increased the periods of the G(0...

journal_title：Biochemical and biophysical research communications

authors： Maki M,Miyazaki H,Nakajima K,Yamane J,Niisato N,Morihara T,Kubo T,Marunaka Y

更新日期：2007-10-05 00:00:00

abstract：:Lysine-specific methyltransferase Set7/9 (KMT7) belongs to the SET domain family of proteins. Besides the SET domain, Set7/9 also contains a so-called MORN (Membrane Occupation and Recognition Nexus) domain whose function in high eukaryotes is largely unknown. Set7/9 has been shown to specifically methylate both histo...

journal_title：Biochemical and biophysical research communications

authors： Vasileva E,Shuvalov O,Petukhov A,Fedorova O,Daks A,Nader R,Barlev N

更新日期：2020-05-14 00:00:00

abstract：:Calreticulin isolated from spinach leaves has been specifically phosphorylated in vitro by protein kinase CK2 while animal calreticulin from rabbit liver is not a substrate of this kinase under the same conditions. Phosphoserine is the only phosphoamino acid detected. High affinity binding (Km = 4.4 microM) and a near...

journal_title：Biochemical and biophysical research communications

authors： Baldan B,Navazio L,Friso A,Mariani P,Meggio F

更新日期：1996-04-25 00:00:00

abstract：:The soil fungus Mucor genevensis was shown to convert exogenous arachidonic acid to the oxylipin 3-hydroxy-5Z,8Z-tetradecadienoic acid (3-HTDE) as determined by gas chromatography/mass spectrometry. This metabolite was only found in the aqueous supernatant together with free linoleic acid, but not in the final fungal ...

journal_title：Biochemical and biophysical research communications

authors： Pohl CH,Botha A,Kock JL,Coetzee DJ,Botes PJ,Schewe T,Nigam S

更新日期：1998-12-30 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) has been shown to negatively regulate adipogenesis. To explore to what extent PGE(2) inhibits the differentiation of cells to adipocytes and to examine whether its effect could be due to EP4 receptor signaling, we used microarrays to analyze the gene expression profiles of 3T3-L1 cells expo...

journal_title：Biochemical and biophysical research communications

authors： Sugimoto Y,Tsuboi H,Okuno Y,Tamba S,Tsuchiya S,Tsujimoto G,Ichikawa A

更新日期：2004-09-24 00:00:00

abstract：:Recent studies from our laboratory demonstrated that Egr-1 is upregulated in the rat duodenal mucosa during cysteamine-induced duodenal ulceration and that antisense egr-1 oligonucleotide aggravates the duodenal ulcers. This study was aimed to determine the effects of cysteamine on redox-sensitive Egr-1 transcriptiona...

journal_title：Biochemical and biophysical research communications

authors： Khomenko T,Deng X,Jadus MR,Szabo S

更新日期：2003-10-03 00:00:00

abstract：:We have created genital skin fibroblast cell lines directly from three patients in a Chinese family affected by androgen insensitivity syndrome (AIS). All patients in the family share an identical AR Arg840Cys mutant but show different disease phenotypes. By using the cell lines, we find that the mutation has not infl...

journal_title：Biochemical and biophysical research communications

authors： Wang M,Wang J,Zhang Z,Zhao Z,Zhang R,Hu X,Tan T,Luo S,Luo Z

更新日期：2005-09-23 00:00:00