Pro-remodeling peptides modulate collagen α1(I) promoter activity in rat cardiac myofibroblasts.

abstract：:An affinity matrix for the purification of norsolorinic acid dehydrogenase, an enzyme involved in aflatoxin biosynthesis, was prepared by coupling norsolorinic acid to an agarose gel. This matrix was found to be ineffective in isolating active enzyme, and was therefore modified by methylation, using diazomethane. The ...

journal_title：Biochemical and biophysical research communications

authors： Chuturgoon AA,Dutton MF,Berry RK

更新日期：1990-01-15 00:00:00

abstract：:Junctional membrane complexes (JMCs) generated by junctophilins are required for Ca(2+)-mediated communication between cell-surface and intracellular channels in excitable cells. Knockout mice lacking neural junctophilins (JP-DKO) show severe motor defects and irregular cerebellar plasticity due to abolished channel c...

journal_title：Biochemical and biophysical research communications

authors： Ikeda A,Miyazaki T,Kakizawa S,Okuno Y,Tsuchiya S,Myomoto A,Saito SY,Yamamoto T,Yamazaki T,Iino M,Tsujimoto G,Watanabe M,Takeshima H

更新日期：2007-11-23 00:00:00

abstract：:Various elicitors were examined by Northern blot analysis to investigate the simultaneous induction of gene expression of antibacterial proteins such as cecropin B, attacin and lebocin from the silkworm, Bombyx mori. Lipopolysaccharide (LPS), lipid A, 2-keto-3-deoxyoctonate (KDO) and peptidoglycan (PG) triggered effic...

journal_title：Biochemical and biophysical research communications

authors： Taniai K,Furukawa S,Shono T,Yamakawa M

更新日期：1996-09-24 00:00:00

abstract：:The oxygen reaction of Nitrosomonas europaea cytochrome c oxidase containing either 2Cu or 1Cu per two heme a molecules was investigated by the flow-flash technique at 20 degrees C. The reaction profiles of the bacterial enzyme were essentially the same as those of bovine heart cytochrome c oxidase, although the rate ...

journal_title：Biochemical and biophysical research communications

authors： Orii Y,Sakamoto T,Fukumori Y,Yamanaka T

更新日期：1992-02-14 00:00:00

abstract：:HL-60 nuclear autophosphorylation was studied in vitro under circumstances in which the conformation of chromatin was manipulated with both polyamines and DNAse-I. A general re-arrangement of the phosphorylation patterns occurred as polyamines were removed and nuclei were observed to expand. DNAse-I treatment reduced ...

journal_title：Biochemical and biophysical research communications

authors： Testori A,Skinner JD,Murray AW,Burgoyne LA

更新日期：1991-10-15 00:00:00

abstract：:Ascent to high-altitude results in decreased inspired partial pressure of oxygen because of a decrease in barometric pressure. Altitude acclimatization requires physiological and metabolic changes to improve tolerance to altitude hypoxia. Cellular response to hypoxia results into changes in the profile of gene express...

journal_title：Biochemical and biophysical research communications

authors： Dolt KS,Karar J,Mishra MK,Salim J,Kumar R,Grover SK,Qadar Pasha MA

更新日期：2007-03-02 00:00:00

abstract：:The objective of this study is to determine whether Rab7 could delay intervertebral disc degeneration and study the mechanism. We chose old mice to established intervertebral disc degeneration model and study the effect of Rab7 on intervertebral disc by western blotting, quantitative real-time PCR, immunohistochemistr...

journal_title：Biochemical and biophysical research communications

authors： Chen X,Zhang P,Ma X

更新日期：2019-06-30 00:00:00

abstract：:Thaumatin, an intensely sweet-tasting protein, elicits a sweet taste sensation at 50 nM. Here the X-ray crystallographic structure of one of its variants, thaumatin II, was determined at a resolution of 1.27 Å. Overall structure of thaumatin II is similar to thaumatin I, but a slight shift of the Cα atom of G96 in tha...

journal_title：Biochemical and biophysical research communications

authors： Masuda T,Ohta K,Tani F,Mikami B,Kitabatake N

更新日期：2011-07-08 00:00:00

abstract：:PI3K activation is commonly observed in many human cancer cells. Survivin expression is elevated in cancer cells, and induced by some growth factors through PI3K activation. However, it is not clear whether PI3K activation is sufficient to induce survivin expression. To investigate the role of PI3K pathway in the regu...

journal_title：Biochemical and biophysical research communications

authors： Zhao P,Meng Q,Liu LZ,You YP,Liu N,Jiang BH

更新日期：2010-04-30 00:00:00

abstract：:The low-energy conformations of 3'-azido-3'-deoxy-thymidine, (AZT), an inhibitor of retroviral reverse transcriptase, have been studied by molecular mechanics techniques. A force-field has been developed for the azido group by quantum-mechanical methods, and used in the analysis. The global low-energy structure of AZT...

journal_title：Biochemical and biophysical research communications

authors： Herzyk P,Beveridge A,Neidle S

更新日期：1987-06-30 00:00:00

abstract：:Tropomyosins are a family of actin binding proteins encoded by a group of highly conserved genes. Humans have four tropomyosin-encoding genes: TPM1, TPM2, TPM3, and TPM4, each of which is known to generate multiple isoforms by alternative splicing, promoters, and 3' end processing. TPM1 is the most versatile and encod...

journal_title：Biochemical and biophysical research communications

authors： Denz CR,Narshi A,Zajdel RW,Dube DK

更新日期：2004-08-06 00:00:00

abstract：:This article has been withdrawn at the request of the author. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Biochemical and biophysical research communications

authors： Seong ES,Cho HS,Choi D,Joung YH,Lim CK,Hur JH,Wang MH

更新日期：2007-11-21 00:00:00

abstract：:The proliferation of colon cancer cells is mediated in part by epidermal growth factor receptor (EGFR) signaling and requires sustained levels of cellular energy to meet its high metabolic needs. Intracellular lipid droplets (LDs) are a source of energy used for various cellular functions and they are elevated in dens...

journal_title：Biochemical and biophysical research communications

authors： Penrose H,Heller S,Cable C,Makboul R,Chadalawada G,Chen Y,Crawford SE,Savkovic SD

更新日期：2016-01-15 00:00:00

abstract：:The mouse gene encoding the mu opioid receptor, Oprm, undergoes extensive alternatively splicing, with 14 variants having been identified. However, only one variant of human mu opioid receptor gene (Oprm), MOR-1A, has been described. We now report two novel splice variants of the human Oprm gene, hMOR-1O and hMOR-1X. ...

journal_title：Biochemical and biophysical research communications

authors： Pan YX,Xu J,Mahurter L,Xu M,Gilbert AK,Pasternak GW

更新日期：2003-02-21 00:00:00

abstract：:Recently, two reports [R. E. Davis et al. (1997) Proc. Natl. Acad. Sci. USA 94, 4564-4569 and E. Fahy et al. (1997) Nucleic Acids Res. 25, 3102-3109] described a series of heteroplasmic mitochondrial DNA (mtDNA) mutations in the genes encoding two cytochrome c oxidase subunits (CO1 and CO2) which segregated in higher ...

journal_title：Biochemical and biophysical research communications

authors： Davis JN 2nd,Parker WD Jr

更新日期：1998-03-27 00:00:00

abstract：:Acute leukemia cells of the established line CEM-C1 were treated during growth in serum-free medium with various concentrations of trans-trans farnesol. At concentrations ranging from 9.0 to 31.5 microM, farnesol inhibited growth of these cells without causing cell lysis. This effect was preceded by very rapid inhibit...

journal_title：Biochemical and biophysical research communications

authors： Melnykovych G,Haug JS,Goldner CM

更新日期：1992-07-15 00:00:00

abstract：:Reactive oxygen species such as hydrogen peroxide (H(2)O(2)) have taken center stage as bona fide second messengers in various signaling pathways. Here, we report the synthesis, metabolic fate, and effectiveness in modulating such pathways of a Tat-catalase conjugate. Incubation of L2 cells with Tat-catalase greatly i...

journal_title：Biochemical and biophysical research communications

authors： Watanabe N,Iwamoto T,Bowen KD,Dickinson DA,Torres M,Forman HJ

更新日期：2003-03-28 00:00:00

abstract：:A novel protein methyltransferase has been recently described that catalyzes the esterification of the C-terminal leucine residue of the catalytic subunit of protein phosphatase 2A in a variety of eucaryotic cells. This reaction can potentially modulate the phosphatase's activity, subunit interactions, or interactions...

journal_title：Biochemical and biophysical research communications

authors： Xie H,Clarke S

更新日期：1994-09-30 00:00:00

abstract：:[3H] imipramine exhibits both saturable and high affinity binding sites in human lung with a maximal number of binding sites of 7.50 pmoles/mg protein and a dissociation constant of 1.74 nM. Displacement studies indicate that these sites can be considered as specific of imipramine, tricyclic compounds and also monoami...

journal_title：Biochemical and biophysical research communications

authors： Morin D,Zini R,Lange J,Tillement JP

更新日期：1984-05-16 00:00:00

abstract：:In this study we have continuously measured real-time production of nitric oxide (NO) in the isolated, perfused rat lung by using an NO monitor (model NO-501, Inter Medical Co., Nagoya, Japan) with an NO-selective resin microsensor. A stable NO response was obtained when the sensor was placed in the pulmonary artery o...

journal_title：Biochemical and biophysical research communications

authors： Wang D,Hsu K,Hwang CP,Chen HI

更新日期：1995-03-28 00:00:00

abstract：:The effects of synthetic atrial natriuretic factor (ANF) were studied in superfused rat posterior pituitary gland. ANF (10(-6)M, 10(-10)M) significantly inhibited basal as well as KC1 (50 mM) or angiotensin II-stimulated immunoreactive arginine vasopressin secretion. The magnitude of inhibition was greater at 10(-6)M ...

journal_title：Biochemical and biophysical research communications

authors： Obana K,Naruse M,Inagami T,Brown AB,Naruse K,Kurimoto F,Sakurai H,Demura H,Shizume K

更新日期：1985-11-15 00:00:00

abstract：:Ultrasound (US) has emerged as a promising noninvasive modality for neuromodulation. Despite previous evidence that US may mediate cellular response by activating mechanosensitive ion channels embedded in the cell membrane, the underlying mechanism is not well understood. In this work, we developed a vertically deploy...

journal_title：Biochemical and biophysical research communications

authors： Liao D,Li F,Lu D,Zhong P

更新日期：2019-10-20 00:00:00

abstract：:Using fluorescein isothiocyanate (FITC)-conjugated H-2K(b) CTL epitope (SIINFEKL) as a model system, we investigated the antigen delivery route by pH-sensitive liposomes in vivo. Fluorescence was initially detected in lymph nodes at 3 h after immunization, and its intensity reached a peak value in superticial inguinal...

journal_title：Biochemical and biophysical research communications

authors： Lee KY,Chun E,Seong BL

更新日期：2002-04-05 00:00:00

abstract：:The role of the hepatitis B virus X protein (HBx) in hepatocarcinogenesis remains controversial. To investigate the biological impact of hepatitis B virus x gene (HBx) mutation on hepatoma cells, plasmids expressing the full-length HBx or HBx deletion mutants were constructed. The biological activities in these transf...

journal_title：Biochemical and biophysical research communications

authors： Liu X,Zhang S,Lin J,Zhang S,Feitelson MA,Gao H,Zhu M

更新日期：2008-09-05 00:00:00

abstract：:Glutaredoxin 3 (GLRX3) is a member of monothiol glutaredoxins with a CGFS active site that has been demonstrated to function in cellular iron sensing and trafficking via its bound iron-sulfur cluster. Human GLRX3 has been shown to form a dimer that binds two bridging [2Fe-2S] clusters with glutathione (GSH) as a ligan...

journal_title：Biochemical and biophysical research communications

authors： Xia H,Li B,Zhang Z,Wang Q,Qiao T,Li K

更新日期：2015-09-25 00:00:00

abstract：:Recently, we reported that in various cell lines under conditions of deenergization of the mitochondrial membrane, the release of Ca(2+) from the endoplasmic reticulum (ER) does not produce the expected activation of store-operated calcium channels (SOCs) in the plasma membrane. In the present work, we examined the ac...

journal_title：Biochemical and biophysical research communications

authors： Wasniewska M,Karczmarewicz E,Pronicki M,Piekutowska-Abramczuk D,Zablocki K,Popowska E,Pronicka E,Duszyński J

更新日期：2001-05-11 00:00:00

abstract：:Alveolar rhabdomyosarcoma (aRMS) is a very aggressive sarcoma of children and young adults. Our previous studies have shown that small molecule inhibition of Pdgfra is initially very effective in an aRMS mouse model. However, slowly evolving, acquired resistance to a narrow-spectrum kinase inhibitor (imatinib) was com...

journal_title：Biochemical and biophysical research communications

authors： Abraham J,Chua YX,Glover JM,Tyner JW,Loriaux MM,Kilcoyne A,Giles FJ,Nelon LD,Carew JS,Ouyang Y,Michalek JE,Pal R,Druker BJ,Rubin BP,Keller C

更新日期：2012-09-28 00:00:00

abstract：:Reactive oxygen species are known to induce strand breaks and/or base modifications in DNA. DNA strand breaks are associated with many pathologies and programmed cell death. We have examined the ability of the polyamines and their analogues to protect phi X-174 plasmid DNA from strand breakage induced by a oxygen-radi...

journal_title：Biochemical and biophysical research communications

authors： Ha HC,Yager JD,Woster PA,Casero RA Jr

更新日期：1998-03-06 00:00:00

abstract：:Studies examining the relationship between cellular sortilin and VLDL-B100 secretion demonstrate inconsistent results. Current studies explore the possibility that discrepancies may be related to insulin sensitivity. McArdle RH7777 cells (McA cells) cultured under serum enriched conditions lose sensitivity to insulin....

journal_title：Biochemical and biophysical research communications

authors： Sparks RP,Guida WC,Sowden MP,Jenkins JL,Starr ML,Fratti RA,Sparks CE,Sparks JD

更新日期：2016-09-16 00:00:00

abstract：:The gamma-isomer of hexachlorocyclohexane (gamma-HCCH), which displays structural homology with inositol, was found to induce an initial influx of Ca2+ in mouse peritoneal macrophages. This was responsible for Ca(2+)-induced Ca2+ release via inositol 1,4,5-trisphosphate produced by phospholipase C and resulted in a su...

journal_title：Biochemical and biophysical research communications

authors： Pinelli E,Cambon C,Tronchère H,Chap H,Teissié J,Pipy B

更新日期：1994-03-15 00:00:00