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miR-137 inhibits glutamine catabolism and growth of malignant melanoma by targeting glutaminase.

Abstract：

:Glutamine catabolism is considered to be an important metabolic pathway for cancer cells. Glutaminase (GLS) is the important rate-limiting enzyme of glutamine catabolism. miR-137 functions as a tumor suppressor in many human malignant tumors. However, the role and molecular mechanism of miR-137 and GLS in malignant melanoma has not been reported. In this study, we showed that miR-137 was decreased in melanoma tissue, and the low miR-137 level and high GLS expression are independent risk factor in melanoma. miR-137 suppressed the proliferation and glutamine catabolism of melanoma cells. GLS is crucial for glutamine catabolism and growth of malignant melanoma. We also demonstrated that miR-137 acts as a tumor suppressor in melanoma by targeting GLS. This result elucidates a new mechanism for miR-137 in melanoma development and provides a survival indicator and potential therapeutic target for melanoma patients.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Luan W,Zhou Z,Zhu Y,Xia Y,Wang J,Xu B

doi

10.1016/j.bbrc.2017.10.152

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

46-52

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(17)32137-X

journal_volume

495

pub_type

杂志文章

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