Monte Carlo studies of lipid chains and gramicidin A in a model membrane.

abstract：:Erythropoietin (EPO) has been known to have cytoprotective effects on several types of tissues, presumably through modulation of apoptosis and inflammation. The effect of EPO on myocardial inflammation, however, has not yet been clarified. We investigated the cardioprotective effects of EPO in rats with experimental a...

journal_title：Biochemical and biophysical research communications

authors： Mitsuma W,Ito M,Kodama M,Fuse K,Okamura K,Minagawa S,Kato K,Hanawa H,Toba K,Nakazawa M,Aizawa Y

更新日期：2006-06-09 00:00:00

abstract：:The carcinogenic function of arachidonate lipoxygenase12 (Alox12) has been reported in various cancers. However, little is known on the role of Alox12 in lung cancer. Here, we demonstrate that Alox12 is upregulated and contributes to biological activities of lung cancer through multiple mechanisms. We found that Alox1...

journal_title：Biochemical and biophysical research communications

authors： Chen J,Tong W,Liao M,Chen D

更新日期：2020-04-16 00:00:00

abstract：:Anamorsin (AM) (also called CIAPIN-1) is a cell-death-defying factor. AM deficient mice die during late gestation; AM deficient embryos are anemic and very small compared to wild type (WT) embryos. It is thought that AM plays crucial roles in hematopoiesis and embryogenesis. To clarify the mechanisms of AM functions, ...

journal_title：Biochemical and biophysical research communications

authors： Saito Y,Shibayama H,Tanaka H,Tanimura A,Matsumura I,Kanakura Y

更新日期：2011-05-06 00:00:00

abstract：:Bryostatin-1 is a natural activator of protein kinase C and currently examined in phase I trials as anticancer agent. We found that Bryostatin-1 induced tumor necrosis factor alpha (TNF alpha) expression in the human cell line MONO-MAC-6. Using Northern blot analysis and a bioassay for the detection of the cytokine we...

journal_title：Biochemical and biophysical research communications

authors： Steube KG,Drexler HG

更新日期：1995-09-25 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) enhances the mitogenic response to epidermal growth factor (EGF) in hepatocytes, but the underlying mechanisms are not clear. We previously observed that PGE(2) upregulates EGF-induced signalling in the MEK/ERK and PI3K/Akt pathways in hepatocytes. Other investigations have indicated that E...

journal_title：Biochemical and biophysical research communications

authors： Ødegård J,Aasrum M,Tveteraas IH,Bharath SP,Sandnes D,Christoffersen T

更新日期：2012-05-04 00:00:00

abstract：:Recent structural investigations on the beta-1,4-galactosyltransferase-1 (Gal-T1) and lactose synthase (LS) have revealed that they are akin to an exquisite mechanical device with two well-coordinated flexible loops that are contained within the Gal-T1 catalytic domain. The smaller one has a Trp residue (Trp314) flank...

journal_title：Biochemical and biophysical research communications

authors： Ramakrishnan B,Boeggeman E,Qasba PK

更新日期：2002-03-15 00:00:00

abstract：:In this study we investigated the role of active site residues in the peroxidase activity of Orp1 (GPx3) using three different peroxide substrates. Using a structural homology model of the reduced form of Orp1, we identified Asn126 and Phe127 as evolutionarily conserved residues that line the back of the Orp1 active s...

journal_title：Biochemical and biophysical research communications

authors： Takanishi CL,Ma LH,Wood MJ

更新日期：2010-12-03 00:00:00

abstract：:Amphotericin B (AmB) is a potent antifungal agent used to treat patients with systemic mycoses. The cytotoxicity of AmB is related to its binding to membrane sterols and its clinical usefulness is based on its greater affinity to ergosterol, the fungal sterol, compared to the mammalian cell sterol, cholesterol (1-3). ...

journal_title：Biochemical and biophysical research communications

authors： Gruda I,Gauthier E,Elberg S,Brajtburg J,Medoff G

更新日期：1988-08-15 00:00:00

abstract：:The recently deorphanized niacin receptor subtypes NIACR1 (GPR109A) and NIACR2 (GPR109B) play an essential role in the regulation of metabolic processes and immune reactions. Both receptors belong to the G-protein-coupled receptor (GPCR) family, whose members have traditionally been treated as monomeric entities, but ...

journal_title：Biochemical and biophysical research communications

authors： Mandrika I,Petrovska R,Klovins J

更新日期：2010-04-30 00:00:00

abstract：:The effects of cyclosporin A (CSP) on tumor necrosis factor-alpha (TNF-alpha) RNA levels and protein production in human B cells and a B cell line were studied. The ability of CSP to block induction of RNA was compared to its inhibition of protein production in response to anti-IgM, phorbol ester (PMA) and platelet-ac...

journal_title：Biochemical and biophysical research communications

authors： Smith CS,Ortega G,Parker L,Shearer WT

更新日期：1994-10-14 00:00:00

abstract：:In this paper we report the first comparative study of cold-adapted imidase (EC 3.5.2.2) from the fish (Oreochromis niloticus) liver and its thermophilic counterparts taken from pig liver and Escherichia coli (overexpressed recombinant hydantoinase from Agrobacterium radiobacter NRRL B1). Approximately 6000-fold purif...

journal_title：Biochemical and biophysical research communications

authors： Huang CY,Yang YS

更新日期：2003-12-12 00:00:00

abstract：:Specific ligands of the peripheral benzodiazepine receptor (PBR) have been shown to induce both apoptosis and G1/G0 cell cycle arrest in colorectal cancers. The signaling pathways leading to cell cycle arrest are still unknown. Using cDNA array technology, we identified signaling molecules involved in cell cycle arres...

journal_title：Biochemical and biophysical research communications

authors： Maaser K,Sutter AP,Krahn A,Höpfner M,Grabowski P,Scherübl H

更新日期：2004-11-12 00:00:00

abstract：:We have investigated the effects of three unrelated topoisomerase 2 inhibitors, genistein, adriamycin, and etoposide, on phosphorylation/activation of the checkpoint kinase Chk2 in normal or ATM-deficient (ATM-) human fibroblasts and in cells overexpressing a catalytically inactive ATR kinase. We demonstrate that geni...

journal_title：Biochemical and biophysical research communications

authors： Théard D,Coisy M,Ducommun B,Concannon P,Darbon JM

更新日期：2001-12-21 00:00:00

abstract：:Tumor promoting phorbol esters inhibited the binding of 125I-[Tyr11] somatostatin to isolated acinar cells from guinea-pig pancreas. Maximal inhibition reached 69.7 +/- 5% at 1 microM TPA. Receptor affinity was decreased by 2.5-fold without change in binding capacity. The ability of TPA in inhibiting somatostatin bind...

journal_title：Biochemical and biophysical research communications

authors： Zeggari M,Susini C,Viguerie N,Esteve JP,Vaysse N,Ribet A

更新日期：1985-04-30 00:00:00

abstract：:Mutations in mitochondrial DNA are one of the important causes of hearing loss. We report here the clinical, genetic, and molecular characterization of two Han Chinese pedigrees with maternally transmitted aminoglycoside-induced and nonsyndromic bilateral hearing loss. Clinical evaluation revealed the wide range of se...

journal_title：Biochemical and biophysical research communications

authors： Yuan H,Chen J,Liu X,Cheng J,Wang X,Yang L,Yang S,Cao J,Kang D,Dai P,Zhai S,Han D,Young WY,Guan MX

更新日期：2007-10-12 00:00:00

abstract：:Phospholipase C (PLC) has been known to be a key effector protein in signal transduction pathway for cell proliferation and differentiation. Here, we report the transcriptional regulation of PLC-gamma 1 during myogenic differentiation. Both PLC-gamma 1 mRNA and protein levels were increased during myogenesis. The acti...

journal_title：Biochemical and biophysical research communications

authors： Lee SJ,Lee YH,Kim YS,Ryu SH,Suh PG

更新日期：1995-01-05 00:00:00

abstract：:We examined the expression of P-glycoprotein in human placentas and hydatidiform moles. Trophoblasts in all the examined placentas and moles expressed P-glycoprotein, and the size of the P-glycoprotein was smaller than that in multidrug-resistant human epidermoid carcinoma KB cells. The P-glycoprotein in the placenta ...

journal_title：Biochemical and biophysical research communications

authors： Nakamura Y,Ikeda S,Furukawa T,Sumizawa T,Tani A,Akiyama S,Nagata Y

更新日期：1997-06-27 00:00:00

abstract：:Preincubation of cultured rat pituitary cells with 10 micrograms/ml of either wheat germ agglutinin (WGA) or concanavalin A inhibited LH release stimulated with GnRH (0.5 nM) by 55% and 40%, respectively. WGA-inhibition of LH release stimulated by GnRH was dose-dependent, reaching a plateau of 75% inhibition at 50 mic...

journal_title：Biochemical and biophysical research communications

authors： Schvartz I,Hazum E

更新日期：1986-10-30 00:00:00

abstract：:We found that heparin at low concentrations increases the vascular endothelial growth factor (VEGF)-induced proliferation of human umbilical vein endothelial cells (HUVECs) but at high concentrations decreases it. To examine whether FLT-1, a VEGF receptor, interacts with heparin and which domain of FLT-1 binds to hepa...

journal_title：Biochemical and biophysical research communications

authors： Park M,Lee ST

更新日期：1999-11-02 00:00:00

abstract：:During our human heart cDNA sequencing project, we have obtained a novel cDNA clone which is very similar in DNA and amino acid sequences to a rat/mouse cysteine-rich intestinal protein (1). Sequence analysis has shown that this human cysteine-rich heart protein (hCRHP) is a protein of 77 amino acids and possesses a L...

journal_title：Biochemical and biophysical research communications

authors： Tsui SK,Yam NY,Lee CY,Waye MM

更新日期：1994-11-30 00:00:00

abstract：:The effect of acetaminophen (APAP) dose on the cytochrome P450s responsible for its bioactivation was examined in control mice and mice treated with acetone to induce CYP2E1, or beta-napthaflavone to induce CYP1A2. In non-induced mice, 150 mg/kg APAP caused minimal hepatotoxicity and loss of CYP2E1- but not CYP1A2-dep...

journal_title：Biochemical and biophysical research communications

authors： Snawder JE,Roe AL,Benson RW,Roberts DW

更新日期：1994-08-30 00:00:00

abstract：:Monodisperse bovine prothrombin was prepared and its molecular states under several conditions examined. The protein showed no tendency to self-associate in the absence of calcium. Calcium (4 mM) caused small increases in the apparent molecular weight of the protein which may or may not represent protein dimerization ...

journal_title：Biochemical and biophysical research communications

authors： Silversmith RE,Wei GJ,Nelsestuen GL

更新日期：1983-02-28 00:00:00

abstract：:We examined the effects of angiotensin II (Ang II) on the proliferation of osteoblast-rich populations of cells obtained from calvariae of newborn rat. Addition of Ang II to the culture medium caused dose-dependent increases in the rate of DNA synthesis. Such increases were completely inhibited by the addition of DuP7...

journal_title：Biochemical and biophysical research communications

authors： Hiruma Y,Inoue A,Hirose S,Hagiwara H

更新日期：1997-01-03 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic, chronic inflammatory disease that is characterized by T helper 17 (Th17) cell- and osteoclast-induced joint destruction and inflammation. In RA, several cytokines (interleukin (IL)-1, 6,17, and tumor necrosis factor (TNF)) are involved in almost all aspects of articular inflamm...

journal_title：Biochemical and biophysical research communications

authors： Park YH,Kim HJ,Lee K,Choi Y,Heo TH

更新日期：2020-02-19 00:00:00

abstract：:Prostate cancer (PCa) is the second leading cause of cancer-associated mortality in men. Speckle-type pox virus and zinc finger protein (SPOP), the most frequently mutated gene in PCa, functions as a tumor suppressor via degradation of cancer-promoting substrates. However, its upstream regulation in PCa metastasis rem...

journal_title：Biochemical and biophysical research communications

authors： Lv W,Huan M,Yang W,Gao Y,Wang K,Xu S,Zhang M,Ma J,Wang X,Chen Y,Li L

更新日期：2020-08-27 00:00:00

abstract：PURPOSE:Kirsten rat sarcoma (KRAS) gene mutations occur early in the progression of colorectal adenoma to carcinoma. The mutation status of the KRAS gene determines the benefits of molecular targeting drugs in patients with advanced colorectal cancer, although many methods are available to detect such mutations. The pu...

journal_title：Biochemical and biophysical research communications

authors： Kobunai T,Watanabe T,Yamamoto Y,Eshima K

更新日期：2010-04-23 00:00:00

abstract：:Aldose reductase has been purified to homogeneity from bovine retina. It has an apparent molecular weight of 32,000 daltons and shares immunological and kinetic properties with the much studied aldose reductases purified from various sources. Retinal aldose reductase displays a K(m) of approximately 40 microM with 4-h...

journal_title：Biochemical and biophysical research communications

authors： He Q,Khanna P,Srivastava S,van Kuijk FJ,Ansari NH

更新日期：1998-06-29 00:00:00

abstract：:Bovine thyroid 100,000 X g supernatant contained calcium-activated, calmodulin-dependent protein kinase (PK-CaM) activity. The PK-CaM was partially purified using ion-exchange chromatography and characterized. PK-CaM, using casein as exogenous substrate, was not stimulated by Ca2+(0-500 microM) or calmodulin (1-10 mic...

journal_title：Biochemical and biophysical research communications

authors： Friedman Y,Henricks L,Poleck T,Levasseur S,Burke G

更新日期：1986-10-15 00:00:00

abstract：:It is found that secretion of pancreastatin and somatostatin from QGP-1N cells is regulated through muscarinic receptor-mediated activation of phosphatidylinositide hydrolysis system. In this report, whether the cAMP pathway interacts with the phosphoinositide turnover system for the secretion of pancreastatin and som...

journal_title：Biochemical and biophysical research communications

authors： Tateishi K,Funakoshi A,Kitayama N,Matsuoka Y

更新日期：1992-06-30 00:00:00

abstract：:Because of the advantages of induced pluripotent stem cells (iPSCs), iPSCs-derived keratinocyte hold great clinical and research potential in wound repair. Similar to other cell transplantation therapies, the migration ability of iPSCs-derived keratinocyte transplanted into skin is critical to the therapeutic effect. ...

journal_title：Biochemical and biophysical research communications

authors： Wu R,Du D,Bo Y,Zhang M,Zhang L,Yan Y

更新日期：2019-11-26 00:00:00