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Differential Ras signaling via the antigen receptor and IL-2 receptor in primary T lymphocytes.

Abstract：

:Ras can become activated via multiple distinct receptors in T lymphocytes. However, mechanistic studies of Ras signaling in normal T cells have been hampered by the lack of an efficient technology for gene transfer into resting post-thymic cells. We have overcome this limitation by utilizing adenoviral transduction of T cells from Coxsackie/adenovirus receptor transgenic mice. Unexpectedly, dominant negative Ras17N blocked activation of Ras and ERK in response to IL-2R engagement but not TCR/CD3 ligation. However, TCR-induced ERK activation was suppressed by inhibitors of PKC and PLC-gamma. This first biochemical study of DN Ras in normal quiescent T cells reveals a striking contrast in Ras signaling via two receptors, and suggests that the principal mechanism of TCR-induced Ras activation in normal T cells may be distinct from that utilized in T-lineage tumor cell lines.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Marks RE,Ho AW,Rivas F,Marshall E,Janardhan S,Gajewski TF

doi

10.1016/j.bbrc.2003.10.168

subject

Has Abstract

pub_date

2003-12-19 00:00:00

pages

691-6

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X03023003

journal_volume

312

pub_type

杂志文章

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