当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Sakuranetin induces adipogenesis of 3T3-L1 cells through enhanced expression of PPARgamma2.

Sakuranetin induces adipogenesis of 3T3-L1 cells through enhanced expression of PPARgamma2.

Abstract：

:Sakuranetin (5,4'-dihydroxy-7-methoxyflavone) belongs to the flavanone class of polyphenols predominantly known as phytoalexin in rice plant. In this study, we demonstrate that sakuranetin strongly induces differentiation of 3T3-L1 preadipocytes, as evidenced by increased triglyceride accumulation and glycerol-3-phosphate dehydrogenase (GPDH) activity. In addition, even in the absence of adipogenic hormonal stimuli, sakuranetin strongly induced adipogenesis and expression of genes that are critical for the adipocytes phenotype. Time-course analyses indicated that sakuranetin induces PPARgamma2 expression without prior induction of C/EBPbeta, a transcriptional regulator of PPARgamma2 in adipogenesis. In 3T3-L1 preadipocytes, the transcriptional factors GATA-2 and GATA-3 are known to down-regulate adipogenesis by direct binding to the C/EBPbeta protein and to the GATA-binding site on the PPARgamma2 promoter. We found that sakuranetin significantly reduced the expression of GATA-2. Moreover, we observed that sakuranetin stimulated glucose uptake in differentiated 3T3-L1 adipocytes. These results suggest that sakuranetin may contribute to maintain glucose homeostasis in animals.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Saito T,Abe D,Sekiya K

doi

10.1016/j.bbrc.2008.05.146

subject

Has Abstract

pub_date

2008-08-08 00:00:00

pages

835-9

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)01066-8

journal_volume

372

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Anti-apoptotic peptides protect against radiation-induced cell death.

    abstract：:The risk of terrorist attacks utilizing either nuclear or radiological weapons has raised concerns about the current lack of effective radioprotectants. Here it is demonstrated that the BH4 peptide domain of the anti-apoptotic protein Bcl-xL can be delivered to cells by covalent attachment to the TAT peptide transduct...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.01.180

    authors： McConnell KW,Muenzer JT,Chang KC,Davis CG,McDunn JE,Coopersmith CM,Hilliard CA,Hotchkiss RS,Grigsby PW,Hunt CR

    更新日期：2007-04-06 00:00:00

  • Identification of two novel markers for alveolar epithelial type I and II cells.

    abstract：:Alveolar epithelial type I and type II cells (AEC I and II) are closely aligned in alveolar surface. There is much interest in the precise identification of AEC I and II in order to separate and evaluate functional and other properties of these two cells. This study aims to identify specific AEC I and AEC II cell mark...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.05.048

    authors： Chen Z,Jin N,Narasaraju T,Chen J,McFarland LR,Scott M,Liu L

    更新日期：2004-07-02 00:00:00

  • Study on dioxygen reduction by mutational modifications of the hydrogen bond network leading from bulk water to the trinuclear copper center in bilirubin oxidase.

    abstract：:The hydrogen bond network leading from bulk water to the trinuclear copper center in bilirubin oxidase is constructed with Glu463 and water molecules to transport protons for the four-electron reduction of dioxygen. Substitutions of Glu463 with Gln or Ala were attributed to virtually complete loss or significant reduc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.06.052

    authors： Morishita H,Kurita D,Kataoka K,Sakurai T

    更新日期：2014-07-18 00:00:00

  • Gamma-interferon counteracts interleukin-1 alpha stimulated expression of urokinase-type plasminogen activator in human endothelial cells in vitro.

    abstract：:The effect of gamma-interferon (gamma-IFN) on the interleukin-1 alpha (IL-1 alpha) induced stimulation of urokinase-type plasminogen activator (u-PA) expression in human foreskin microvascular endothelial cells (HFMEC) and in human umbilical vein endothelial cells (HUVEC) was investigated. When gamma-IFN and IL-1 alph...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)92407-o

    authors： Wojta J,Zoellner H,Gallicchio M,Hamilton JA,McGrath K

    更新日期：1992-10-15 00:00:00

  • Cultured tonsillar lymphocytes excrete [3H]thymidine labeled DNA and revert to resting state.

    abstract：:Large tonsillar lymphocytes labeled with [3H]thymidine reverted to small lymphocytes with concomitant loss of [3H]DNA upon culturing. The decrease of labeled DNA content and size of large lymphocytes was demonstrated by flow cytometry and cell sorting. These observations suggest that stimulated lymphocytes may revert ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91398-6

    authors： Sasvari-Szekely M,Staub M,Taljanidisz J,Szabo G Jr,Takacs J,Antoni F

    更新日期：1984-12-28 00:00:00

  • Phorbol 12-myristate 13-acetate activates rabbit neutrophils without an apparent rise in the level of intracellular free calcium.

    abstract：:The addition of low concentrations of phorbol 12-myristate 13-acetate to rabbit neutrophils induces cell aggregation, degranulation, increased oxygen consumption and an increase in the amount of actin associated with the cytoskeleton without a rise in the level of intracellular free calcium as measured using the fluor...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)90828-8

    authors： Sha'afi RI,White JR,Molski TF,Shefcyk J,Volpi M,Naccache PH,Feinstein MB

    更新日期：1983-07-29 00:00:00

  • Polymorphic and differential expression of the Trypanosoma cruzi alleles containing universal minicircle binding protein.

    abstract：:DNA replication mechanisms are poorly understood in most of trypanosomatids, in particular the replication of the peculiar mitochondrial DNA, the kinetoplast DNA (kDNA). To contribute to the knowledge on the mechanism of kDNA replication in Trypanosoma cruzi, we have previously characterized the Universal Minicircle S...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.12.189

    authors： Coelho ER,Rodrigues Dde C,Urményi TP,Rondinelli E,Silva R

    更新日期：2006-03-10 00:00:00

  • Combination of 3-methyladenine therapy and Asn-Gly-Arg (NGR)-modified mesoporous silica nanoparticles loaded with temozolomide for glioma therapy in vitro.

    abstract：:Mesoporous silica nanoparticles (MSNPs) of a small diameter were loaded with the anticancer drug temozolomide (TMZ), coated with polydopamine (PDA), and conjugated with Asn-Gly-Arg (NGR) for use in the treatment of glioma. The accumulation of NGR-MSNPs in C6 cells was shown to be higher than that of unmodified MSNPs. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.12.158

    authors： Zhang P,Tang M,Huang Q,Zhao G,Huang N,Zhang X,Tan Y,Cheng Y

    更新日期：2019-02-05 00:00:00

  • Rapid loss in the mitochondrial membrane potential during geranylgeranoic acid-induced apoptosis.

    abstract：:A synthetic geranylgeranoic acid (GGA) induced apoptotic cell death in a human hepatoma cell line, HuH-7, but not in mouse primary cultured hepatocytes. Prior to chromatin condensation, GGA induced a dramatic loss of the mitochondrial membrane potential in 1 hour and in a dose dependent manner in HuH-7 cells, but not ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.5883

    authors： Shidoji Y,Nakamura N,Moriwaki H,Muto Y

    更新日期：1997-01-03 00:00:00

  • Catabolism of pentachlorophenol by a Flavobacterium sp.

    abstract：:The pathway employed for pentachlorophenol (PCP) degradation by an aerobic, chlorophenol-utilizing Flavobacterium sp. was initiated by conversion of PCP to tetrachloro-p-hydroquinone (TCH). 18O labelling experiments demonstrated that the first dechlorination, where a hydroxyl replaced the chlorine at PCP ring position...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80247-9

    authors： Steiert JG,Crawford RL

    更新日期：1986-12-15 00:00:00

  • The phosphorylation of Sorghum leaf phosphoenolpyruvate carboxylase is a Ca++-calmodulin dependent process.

    abstract：:Regulation of the in vitro phosphorylation process of the photosynthetic form (G form) of Sorghum leaf Phosphoenolpyruvate carboxylase (PEPC: EC 4.1.1.31) was studied. Results established that: 1) PEPC was efficiently phosphorylated on seryl residues in crude leaf extract 2) Pyruvate, orthophosphate dikinase (EC 2.7.9...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80571-0

    authors： Echevarría C,Yidal J,Le Maréchal P,Brulfert J,Ranjeva R,Gadal P

    更新日期：1988-09-15 00:00:00

  • Vaspin protects vascular endothelial cells against free fatty acid-induced apoptosis through a phosphatidylinositol 3-kinase/Akt pathway.

    abstract：:Vaspin, an adipocytokine recently identified in a rat model of type 2 diabetes, has been suggested to have an insulin-sensitizing effect. However, the exact mechanism underlying this action has not been fully elucidated. Furthermore, the specific function of vaspin is largely unknown, especially in vascular cells. We ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.08.083

    authors： Jung CH,Lee WJ,Hwang JY,Seol SM,Kim YM,Lee YL,Park JY

    更新日期：2011-09-23 00:00:00

  • Expression of programmed cell death protein 4 (PDCD4) and miR-21 in urothelial carcinoma.

    abstract：BACKGROUND:We investigated the role of the programmed cell death 4 (PDCD4) tumor suppressor gene in specimens of transitional cell carcinoma and of healthy individuals. METHODS:PDCD4 immunohistochemical expression was investigated in 294 cases in histologically proven transitional cell carcinoma in different tumorous ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.11.035

    authors： Fischer N,Göke F,Splittstösser V,Lankat-Buttgereit B,Müller SC,Ellinger J

    更新日期：2012-01-06 00:00:00

  • Characterization of cDNA for a dehydration-inducible gene that encodes a CLP A, B-like protein in Arabidopsis thaliana L.

    abstract：:Sequence was obtained from a cDNA clone, designated ERD1, isolated from a cDNA library of 1-hour-dehydrated plants of Arabidopsis thaliana L. The clone (3150 bp) contains an open reading frame of 946 amino acid residues with greater than 34% sequence identity to the regulatory subunit of the Clp ATP-dependent protease...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2381

    authors： Kiyosue T,Yamaguchi-Shinozaki K,Shinozaki K

    更新日期：1993-11-15 00:00:00

  • Site-directed mutagenesis of a novel serine arylesterase from Vibrio mimicus identifies residues essential for catalysis.

    abstract：:Site-directed mutagenesis (SDM) of an arylesterase (the arylesterase) from Vibrio mimicus revealed that residues S29, H153, and D96 constituted a catalytic triad. The use of a serine residue for ester hydrolysis by the arylesterase proves that the enzyme is a novel serine arylesterase. SDM also showed that D28 was nec...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0620

    authors： Chang RC,Chen JC,Shaw JF

    更新日期：1996-04-16 00:00:00

  • Expression profile analysis of colon cancer cells in response to sulindac or aspirin.

    abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) have a preventive effect against colorectal cancer. Although inhibition of cyclooxygenase-2 plays a crucial role in the suppression of tumors, precise mechanisms of their action remain to be disclosed. To identify genes involved in the growth-suppressive effect of NSAIDs, ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2002.6648

    authors： Iizaka M,Furukawa Y,Tsunoda T,Akashi H,Ogawa M,Nakamura Y

    更新日期：2002-03-29 00:00:00

  • Cholecystokinin elevates cytosolic calcium in small cell lung cancer cells.

    abstract：:The ability of cholecystokinin (CCK) to elevate intracellular Ca2+ levels in small cell lung cancer cells was investigated using the fluorescent Ca2+ indicator Fura 2. CCK-8 elevated the cytosolic Ca2+ levels in cell line NCI-H345 in a dose dependent manner. Nanomolar concentration of CCK-8 elevated cytosolic Ca2+ lev...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92180-3

    authors： Staley J,Fiskum G,Moody TW

    更新日期：1989-08-30 00:00:00

  • Cleavage-induced termination in U2 snRNA gene expression.

    abstract：:The maturation of many small nuclear RNAs is dependent on RNase III-like endonuclease mediated cleavage, which generates a loading site for the exosome complex that trims the precursor at its 3' end. Using a temperature sensitive Pac1 nuclease, here we show that the endonuclease cleavage is equally important in termin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.02.023

    authors： Nabavi S,Nazar RN

    更新日期：2010-03-12 00:00:00

  • Phospholipase C: a putative mechanotransducer for endothelial cell response to acute hemodynamic changes.

    abstract：:Endothelial cells (EC) in vivo are exposed to a multitude of physical forces with each pulse of the cardiac cycle. Ongoing studies support the concept that EC respond to these forces through specific signal transduction pathways. Previous investigations in our laboratory have shown that EC respond to the initiation of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1087

    authors： Brophy CM,Mills I,Rosales O,Isales C,Sumpio BE

    更新日期：1993-01-29 00:00:00

  • Members of the histone deacetylase superfamily differ in substrate specificity towards small synthetic substrates.

    abstract：:Histone deacetylases (HDACs) are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. Deacetylation of epsilon-acetyl-lysine residues within the N-terminal tail of core histones mediates changes in both histone-DNA and histone-non-histone protein interactions. However, surprisin...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.09.155

    authors： Riester D,Wegener D,Hildmann C,Schwienhorst A

    更新日期：2004-11-19 00:00:00

  • IL-7 splicing variant IL-7δ5 induces human breast cancer cell proliferation via activation of PI3K/Akt pathway.

    abstract：:Various tumor cells express interleukin 7 (IL-7) and IL-7 variants. IL-7 has been confirmed to stimulate solid tumor cell proliferation. However, the effect of IL-7 variants on tumor cell proliferation remains unclear. In this study, we evaluated the role of IL-7δ5 (an IL-7 variant lacking exon 5) on proliferation and...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.05.070

    authors： Pan D,Liu B,Jin X,Zhu J

    更新日期：2012-06-15 00:00:00

  • SUMOylation regulates nuclear localization and stability of TRAIP/RNF206.

    abstract：:TRAIP/RNF206 plays diverse roles in cell cycle progression, DNA damage response, and DNA repair pathways. Physiological importance of TRAIP is highlighted by the identification of pathogenic mutations of TRAIP gene in patients diagnosed with primordial dwarfism. Although the diverse functions of TRAIP in the nucleus h...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.01.141

    authors： Park IS,Han Yg,Chung HJ,Jung YW,Kim Y,Kim H

    更新日期：2016-02-19 00:00:00

  • Feedback-type inhibition of activity of 3-hydroxy-3-methylglutaryl coenzyme a reductase by ubiquinone.

    abstract：:Accompanying the decrease in serum cholesterol and increase in concentration of ubiquinone in liver and its microsomes, the activity, but not the protein, of HMG-CoA reductase decreased in ubiquinone-supplemented rats. A soluble 58-kDa preparation of HMG-CoA reductase was partially inhibited on addition of ubiquinone ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)80021-x

    authors： Omkumar RV,Gaikwad AS,Ramasarma T

    更新日期：1992-05-15 00:00:00

  • Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant.

    abstract：:Transgenic mice expressing the rhodopsin mutant Pro347Ser (Serine 6) display retinal degeneration through apoptosis that is characteristic of the disease retinitis pigmentosa. By 5 weeks after birth, these mice have lost approximately 35% of their photoreceptor cells. Retinas from these mice showed higher levels of cA...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2686

    authors： Weiss ER,Hao Y,Dickerson CD,Osawa S,Shi W,Zhang L,Wong F

    更新日期：1995-11-22 00:00:00

  • Purification of Trypanosoma cruzi surface proteins involved in adhesion to host cells.

    abstract：:We have identified four surface 83 kDa proteins of pI values 6.3, 6.4, 6.5 and 6.6 in T. cruzi trypomastigotes which specifically bind to rat heart myoblasts. These proteins were purified by isoelectric focusing and anion-exchange chromatography in an FPLC system. These 83 kDa proteins inhibit the attachment of trypom...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)90764-e

    authors： Villalta F,Lima MF,Zhou L

    更新日期：1990-10-30 00:00:00

  • The histone deacetylase SIRT6 suppresses the expression of the RNA-binding protein PCBP2 in glioma.

    abstract：:More than 80% of tumors that occur in the brain are malignant gliomas. The prognosis of glioma patients is still poor, which makes glioma an urgent subject of cancer research. Previous evidence and our present data show that PCBP2 is over-expressed in human glioma tissues and predicts poor outcome. However, the mechan...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.02.116

    authors： Chen X,Hao B,Liu Y,Dai D,Han G,Li Y,Wu X,Zhou X,Yue Z,Wang L,Cao Y,Liu J

    更新日期：2014-03-28 00:00:00

  • Reduction of PTP1B by RNAi upregulates the activity of insulin controlled fatty acid synthase promoter.

    abstract：:Metabolic deregulation accompanying type II diabetes is characterized by insulin resistance in peripheral tissues (liver, muscle, and adipose), mediated by impairments in insulin receptor (IR) signaling. Protein tyrosine phosphatase 1B (PTP1B) has been shown to be a negative regulator of IR autophosphorylation and thu...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.02.016

    authors： Xu J,Li L,Qian Z,Hong J,Shen S,Huang W

    更新日期：2005-04-08 00:00:00

  • Human myeloma cells acquire resistance to difluoromethylornithine without overproducing ornithine decarboxylase.

    abstract：:An exposure of a human myeloma cell line to 2-difluoromethylornithine the mechanism-based inhibitor of ornithine decarboxylase (EC 4.1.1.17), resulted in a selection of tumor cells readily growing in the presence of 4 mM difluoromethylornithine, a concentration that swiftly halted the growth of the parental cells. Det...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(87)80485-0

    authors： Alhonen-Hongisto L,Leinonen P,Laine R,Jänne J

    更新日期：1987-04-14 00:00:00

  • A novel type of single-stranded nucleic acid binding protein recognizing a highly frequent motif in the intergenic regions of Trypanosoma cruzi.

    abstract：:Regulation of gene expression in trypanosomatids is not yet well understood. Genes are organized in long polycistronic transcriptional units separated by intergenic regions that may contain the signaling information for nucleic acid processing. Poly-dinucleotides are frequent in these regions and have been proposed to...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)01561-4

    authors： Duhagon MA,Dallagiovanna B,Ciganda M,Ruyechan W,Williams N,Garat B

    更新日期：2003-09-12 00:00:00

  • Engagement of spectrin and actin in capping of FcgammaRII revealed by studies on permeabilized U937 cells.

    abstract：:Plasma membrane receptors can undergo translocation in the plane of plasma membrane after binding of polyvalent ligands. Ligand/receptor clusters, named patches, can collect into a polar cap, presumably due to their association with the submembrane actin-based cytoskeleton. We found that the assembly of Fcgamma recept...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0769

    authors： Kwiatkowska K,Sobota A

    更新日期：1999-06-07 00:00:00