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Human myeloma cells acquire resistance to difluoromethylornithine without overproducing ornithine decarboxylase.

Abstract：

:An exposure of a human myeloma cell line to 2-difluoromethylornithine the mechanism-based inhibitor of ornithine decarboxylase (EC 4.1.1.17), resulted in a selection of tumor cells readily growing in the presence of 4 mM difluoromethylornithine, a concentration that swiftly halted the growth of the parental cells. Determination of the intracellular polyamines revealed that there were measurable amounts of putrescine and spermidine in the resistant cells. Restriction enzyme analyses of genomic DNA isolated from the resistant cells indicated that the gene dosage for ornithine decarboxylase was not increased to any appreciable extent. Similarly, the accumulation of mRNA was unaltered. The resistant myeloma cells, however, displayed arginase (EC 3.5.3.1) activity that was roughly ten times higher than that in the parental cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Alhonen-Hongisto L,Leinonen P,Laine R,Jänne J

doi

10.1016/s0006-291x(87)80485-0

subject

Has Abstract

pub_date

1987-04-14 00:00:00

pages

132-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(87)80485-0

journal_volume

144

pub_type

杂志文章

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